Sökning: onr:"swepub:oai:gup.ub.gu.se/275999" > Plasma circulating ...
Fältnamn | Indikatorer | Metadata |
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000 | 03282naa a2200493 4500 | |
001 | oai:gup.ub.gu.se/275999 | |
003 | SwePub | |
008 | 240528s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/2759992 URI |
024 | 7 | a https://doi.org/10.1002/hed.255632 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Egyud, Matthew4 aut |
245 | 1 0 | a Plasma circulating tumor DNA as a potential tool for disease monitoring in head and neck cancer. |
264 | c 2018-12-15 | |
264 | 1 | b Wiley,c 2019 |
520 | a Recommendations for perioperative therapy in head and neck cancer are not explicit and recurrence occurs frequently. Circulating tumor DNA is an emerging cancer biomarker, but has not been extensively explored for detection of recurrence in head and neck cancer.Patients diagnosed with head and neck squamous cell carcinoma were recruited into the study protocol. Tumors were sequenced to identify patient-specific mutations. Mutations were then identified in plasma circulating tumor DNA from pre-treatment blood samples and longitudinally during standard follow-up. Circulating tumor DNA status during follow-up was correlated to disease recurrence.Samples were taken from eight patients. Tumor mutations were verified in seven patients. Baseline circulating tumor DNA was positive in six patients. Recurrence occurred in four patients, two of whom had detectable circulating tumor DNA prior to recurrence.Circulating tumor DNA is a potential tool for disease and recurrence monitoring following curative therapy in head and neck cancer, allowing for better prognostication, and/or modification of treatment strategies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a cancer biomarker | |
653 | a diagnostics | |
653 | a cell-free DNA | |
653 | a circulating tumor DNA | |
653 | a liquid biopsy. | |
700 | 1 | a Sridhar, Praveen4 aut |
700 | 1 | a Devaiah, Anand4 aut |
700 | 1 | a Yamada, Emiko4 aut |
700 | 1 | a Saunders, Stefanie4 aut |
700 | 1 | a Ståhlberg, Anders,d 1975u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Wallenberg Centre for Molecular and Translational Medicine,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine4 aut0 (Swepub:gu)xsandw |
700 | 1 | a Filges, Stefan,d 1991u Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center4 aut0 (Swepub:gu)xfilst |
700 | 1 | a Krzyzanowski, Paul M4 aut |
700 | 1 | a Kalatskaya, Irina4 aut |
700 | 1 | a Jiao, Wei4 aut |
700 | 1 | a Stein, Lincoln D4 aut |
700 | 1 | a Jalisi, Scharukh4 aut |
700 | 1 | a Godfrey, Tony E4 aut |
710 | 2 | a Göteborgs universitetb Sahlgrenska Cancer Center4 org |
773 | 0 | t Head & neckd : Wileyg 41:5, s. 1351-1358q 41:5<1351-1358x 1097-0347x 1043-3074 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hed.25563 |
856 | 4 8 | u https://gup.ub.gu.se/publication/275999 |
856 | 4 8 | u https://doi.org/10.1002/hed.25563 |
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