L773:1542 0086
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02524naa a2200301 4500 | |
| 001 | oai:DiVA.org:liu-14280 | |
| 003 | SwePub | |
| 008 | 070201s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142802 URI |
| 024 | 7 | a https://doi.org/10.1529/biophysj.105.0800282 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Akanda, Nesaru Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)nesak91 |
| 245 | 1 0 | a Biophysical properties of the apoptosis-inducing plasma membrane voltage-dependent anion channel |
| 264 | 1 | b Elsevier BV,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a Ion channels in the plasma membrane play critical roles in apoptosis. In a recent study we found that a voltage-dependent anion channel in the plasma membrane (VDACpl) of neuronal hippocampal cell line (HT22) cells was activated during apoptosis and that channel block prevented apoptosis. Whether or not VDACpl is identical to the mitochondrial VDACmt has been debated. Here, we biophysically characterize the apoptosis-inducing VDACpl and compare it with other reports of VDACpls and VDACmt. Excised membrane patches of apoptotic HT22 cells were studied with the patch-clamp technique. VDACpl has a large main-conductance state (400 pS) and occasionally subconductance states of µ28 pS and 220 pS. The small subconductance state is associated with long-lived inactivated states, and the large subconductance state is associated with excision of the membrane patch and subsequent activation of the channel. The open-probability curve is bell shaped with its peak around 0mV and is blocked by 30µM Gd3+. The gating can be described by a symmetrical seven-state model with one open state and six closed or inactivated states. These channel properties are similar to those of VDACmt and other VDACpls and are discussed in relation to apoptosis. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Elinder, Fredriku Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)freel71 |
| 710 | 2 | a Linköpings universitetb Cellbiologi4 org |
| 773 | 0 | t Biophysical Journald : Elsevier BVg 90:12, s. 4405-4417q 90:12<4405-4417x 0006-3495x 1542-0086 |
| 856 | 4 | u http://www.cell.com/article/S0006349506726170/pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-14280 |
| 856 | 4 8 | u https://doi.org/10.1529/biophysj.105.080028 |
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