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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005330naa a2200577 4500
001oai:gup.ub.gu.se/72524
003SwePub
008240910s2008 | |||||||||||000 ||eng|
009oai:research.chalmers.se:d1797128-b8ab-4ab2-97ad-e251db1a93b0
0247 a https://gup.ub.gu.se/publication/725242 URI
0247 a https://doi.org/10.1186/1741-7007-6-262 DOI
0247 a https://research.chalmers.se/publication/725242 URI
040 a (SwePub)gud (SwePub)cth
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bienert, Gern,d 20084 aut
2451 0a A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes
264 c 2008-06-10
264 1b Springer Science and Business Media LLC,c 2008
520 a Background Arsenic is a toxic and highly abundant metalloid that endangers human health through drinking water and the food chain. The most common forms of arsenic in the environment are arsenate (As(V)) and arsenite (As(III)). As(V) is a non-functional phosphate analog that enters the food chain via plant phosphate transporters. Inside cells, As(V) becomes reduced to As(III) for subsequent extrusion or compartmentation. Although much is known about As(III) transport and handling in microbes and mammals, the transport systems for As(III) have not yet been characterized in plants. Results Here we show that the Nodulin26-like Intrinsic Proteins (NIPs) AtNIP5;1 and AtNIP6;1 from Arabidopsis thaliana, OsNIP2;1 and OsNIP3;2 from Oryza sativa, and LjNIP5;1 and LjNIP6;1 from Lotus japonicus are bi-directional As(III) channels. Expression of these NIPs sensitized yeast cells to As(III) and antimonite (Sb(III)), and direct transport assays confirmed their ability to facilitate As(III) transport across cell membranes. On medium containing As(V), expression of the same NIPs improved yeast growth, probably due to increased As(III) efflux. Our data furthermore provide evidence that NIPs can discriminate between highly similar substrates and that they may have differential preferences in the direction of transport. A subgroup of As(III) permeable channels that group together in a phylogenetic tree required N-terminal truncation for functional expression in yeast. Conclusion This is the first molecular identification of plant As(III) transport systems and we propose that metalloid transport through NIPs is a conserved and ancient feature. Our observations are potentially of great importance for improved remediation and tolerance of plants, and may provide a key to the development of low arsenic crops for food production.
650 7a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng
650 7a NATURVETENSKAPx Biologix Botanik0 (SwePub)106072 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Botany0 (SwePub)106072 hsv//eng
650 7a NATURVETENSKAPx Biologix Annan biologi0 (SwePub)106992 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Other Biological Topics0 (SwePub)106992 hsv//eng
650 7a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
653 a plant aquaporins
653 a arsenic
653 a sequence analysis
653 a membrane transport
653 a sequence analysis
7001 a Thorsen, Michael,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xthomi
7001 a Schüssler, Manuela4 aut
7001 a Nilsson, R. Henrik,d 1976u Gothenburg University,Göteborgs universitet,Institutionen för växt- och miljövetenskaper,Department of Plant and Environmental Sciences,University of Gothenburg4 aut0 (Swepub:gu)xnihen
7001 a Wagner, Annemarie,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för kemi,Department of Chemistry,University of Gothenburg4 aut0 (Swepub:cth)wagnera
7001 a Tamás, Markus J.,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,University of Gothenburg4 aut0 (Swepub:gu)xtamma
7001 a Jahn, Thomas4 aut
7102 a Göteborgs universitetb Institutionen för cell- och molekylärbiologi4 org
7730 t BMC Biologyd : Springer Science and Business Media LLCg 6:26q 6:26x 1741-7007
8564 u https://bmcbiol.biomedcentral.com/track/pdf/10.1186/1741-7007-6-26
8564 8u https://gup.ub.gu.se/publication/72524
8564 8u https://doi.org/10.1186/1741-7007-6-26
8564 8u https://research.chalmers.se/publication/72524

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