L773:1872 8227 OR L773:0168 8227
Sökning: L773:1872 8227 OR L773:0168 8227 > (2020-2024) > Time-trends in body...
Time-trends in body mass index, and overweight and obesity as independent risk factors for diabetes angiopathy in young females with type 1 diabetes : A nationwide study in Sweden
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- Haas, Josephine (författare)
- Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden.
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- Franko, Mikael Andersson (författare)
- Karolinska Institutet
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- Lindholm Olinder, Anna, PhD, 1960- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden.
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- Karolinska Institutet Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden;Sachsska Children & Youth Hosp, Sodersjukhuset, S-11883 Stockholm, Sweden. (creator_code:org_t)
- Elsevier BV, 2023
- 2023
- Engelska.
- Ingår i: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 204
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Aims: To examine time-trends in BMI-distributions of young females with and without type 1 diabetes (T1D), with focus on the upper half of the distribution i.e., the median and above, and to explore if overweight and obesity independently increase risk of diabetes angiopathy.Methods: Population-based cohort study of 3,473 females with T1D, 16-35 years, identified in the Swedish National Diabetes Registers, January 2005 to October 2015, and 8,487 females from the background population. BMI-distributions were examined using kernel density estimates and quantile regression. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for angiopathy in overweight/obese subjects were estimated with adjusted Cox regression.Results: The BMI-distribution in females with T1D was right shifted to that of the background population (p < 0.001). The 90th percentile and median BMI increased equally overtime in both groups, but females with T1D started from a higher baseline. In T1D, HRs were significantly increased for any angiopathy in individuals with obesity (adj HR 1.37 (CI 1.14-1.64)), and for retinopathy; adj HRs (CIs): overweight; 1.15 (1.02-1.29), obesity; 1.30 (1.08-1.56).Conclusions: Females with T1D have increasing BMI overtime and are heavier than females without T1D. Overweight and obesity are by themselves risk factors for angiopathy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Type 1 diabetes
- Female
- Body Mass Index
- Diabetes angiopathy
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- ref (ämneskategori)
- art (ämneskategori)
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- Haas, Josephine
- Franko, Mikael A ...
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- Nystrom, Thomas
- Persson, Martina
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