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Sökning: WFRF:(Åhs Fredrik) > (2010-2014) > Amygdala Subregions...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005973naa a2200625 4500
001oai:DiVA.org:uu-181544
003SwePub
008120925s2012 | |||||||||||000 ||eng|
009oai:DiVA.org:miun-38898
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1815442 URI
0247 a https://doi.org/10.1038/npp.2012.722 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-388982 URI
040 a (SwePub)uud (SwePub)miun
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Faria, Vandau Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)vanfa785
2451 0a Amygdala Subregions Tied to SSRI and Placebo Response in Patients with Social Anxiety Disorder
264 c 2012-05-23
264 1b Nature Publishing Group,c 2012
338 a print2 rdacarrier
520 a The amygdala is a key structure in the pathophysiology of anxiety disorders, and a putative target for anxiolytic treatments, Selective serotonin reuptake inhibitors (SSRIs) and placebo seem to induce anxiolytic effects by attenuating amygdala responsiveness. However, conflicting amygdala findings have also been reported. Moreover, the neural profile of responders and nonresponders is insufficiently characterized and it remains unknown whether SSRIs and placebo engage common or distinct amygdala subregions or different modulatory cortical areas. We examined similarities and differences in the neural response to SSRIs and placebo in patients with social anxiety disorder (SAD). Positron emission tomography (PET) with oxygen-15-labeled water was used to assess regional cerebral blood flow (rCBF) in 72 patients with SAD during an anxiogenic public speaking task, before and after 6-8 weeks of treatment under double-blind conditions. Response rate was determined by the Clinical Global Impression-Improvement scale. Conjunction analysis revealed a common rCBF-attenuation from pre- to post-treatment in responders to SSRIs and placebo in the left basomedial/basolateral and right ventrolateral amygdala. This rCBF pattern con-elated with behavioral measures of reduced anxiety and differentiated responders from nonresponders. However, nonanxiolytic treatment effects were also observed in the amygdala. All subgroups, including nonresponders, showed deactivation of the left lateral part of the amygdala. No rCBF differences were found between SSRI responders and placebo responders. This study provides new insights into the brain dynamics underlying anxiety relief by demonstrating common amygdala targets for pharmacologically and psychologically induced anxiety reduction, and by showing that the amygdala is functionally heterogeneous in anxiolysis.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe
650 7a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng
653 a amygdala
653 a SSRIs
653 a placebo
653 a SAD
653 a subregions
653 a PET
653 a Neuroscience
653 a Neurovetenskap
7001 a Appel, Lieuweu Uppsala universitet,Enheten för nuklearmedicin och PET,Department of Nuclear Medicine and PET, Uppsala University, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)lap02157
7001 a Åhs, Fredriku Uppsala universitet,Institutionen för psykologi,Department of Psychology and Neuroscience, Duke University, Durham, NC, USA,Department of Psychology and Neuroscience, Duke University, Durham, NC, United States4 aut0 (Swepub:miun)freahs
7001 a Linnman, Clasu P.A.I.N. Group, Department of Anesthesia, Children's Hospital, Boston, MA, USA,P.A.I.N. Group, Department of Anesthesia, Childrens Hospital, Boston, MA, United States4 aut
7001 a Pissiota, Annau Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut
7001 a Frans, Örjanu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)orjafran
7001 a Bani, Massimou GlaxoSmithKline, Medicine Research Centre, Verona, Italy4 aut
7001 a Bettica, Paolou GlaxoSmithKline, Medicine Research Centre, Verona, Italy4 aut
7001 a M Pich, Emiliou GlaxoSmithKline, Medicine Research Centre, Verona, Italy; F. Hoffman la Roche, Pharmaceutical Division, PRED, Basel, Switzerland4 aut
7001 a Jacobsson, Evau Uppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden4 aut
7001 a Wahlsted, Kurtu Uppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden4 aut
7001 a Fredrikson, Matsu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)matsfred
7001 a Furmark, Tomasu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)tomafurm
7102 a Uppsala universitetb Institutionen för psykologi4 org
7730 t Neuropsychopharmacologyd : Nature Publishing Groupg 37:10, s. 2222-2232q 37:10<2222-2232x 0893-133Xx 1740-634X
8564 u https://www.nature.com/articles/npp201272.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181544
8564 8u https://doi.org/10.1038/npp.2012.72
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38898

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