Sökning: WFRF:(Åhs Fredrik) > (2010-2014) > Amygdala Subregions...
Fältnamn | Indikatorer | Metadata |
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000 | 05973naa a2200625 4500 | |
001 | oai:DiVA.org:uu-181544 | |
003 | SwePub | |
008 | 120925s2012 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:miun-38898 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1815442 URI |
024 | 7 | a https://doi.org/10.1038/npp.2012.722 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-388982 URI |
040 | a (SwePub)uud (SwePub)miun | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Faria, Vandau Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)vanfa785 |
245 | 1 0 | a Amygdala Subregions Tied to SSRI and Placebo Response in Patients with Social Anxiety Disorder |
264 | c 2012-05-23 | |
264 | 1 | b Nature Publishing Group,c 2012 |
338 | a print2 rdacarrier | |
520 | a The amygdala is a key structure in the pathophysiology of anxiety disorders, and a putative target for anxiolytic treatments, Selective serotonin reuptake inhibitors (SSRIs) and placebo seem to induce anxiolytic effects by attenuating amygdala responsiveness. However, conflicting amygdala findings have also been reported. Moreover, the neural profile of responders and nonresponders is insufficiently characterized and it remains unknown whether SSRIs and placebo engage common or distinct amygdala subregions or different modulatory cortical areas. We examined similarities and differences in the neural response to SSRIs and placebo in patients with social anxiety disorder (SAD). Positron emission tomography (PET) with oxygen-15-labeled water was used to assess regional cerebral blood flow (rCBF) in 72 patients with SAD during an anxiogenic public speaking task, before and after 6-8 weeks of treatment under double-blind conditions. Response rate was determined by the Clinical Global Impression-Improvement scale. Conjunction analysis revealed a common rCBF-attenuation from pre- to post-treatment in responders to SSRIs and placebo in the left basomedial/basolateral and right ventrolateral amygdala. This rCBF pattern con-elated with behavioral measures of reduced anxiety and differentiated responders from nonresponders. However, nonanxiolytic treatment effects were also observed in the amygdala. All subgroups, including nonresponders, showed deactivation of the left lateral part of the amygdala. No rCBF differences were found between SSRI responders and placebo responders. This study provides new insights into the brain dynamics underlying anxiety relief by demonstrating common amygdala targets for pharmacologically and psychologically induced anxiety reduction, and by showing that the amygdala is functionally heterogeneous in anxiolysis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a SAMHÄLLSVETENSKAPx Psykologi0 (SwePub)5012 hsv//swe |
650 | 7 | a SOCIAL SCIENCESx Psychology0 (SwePub)5012 hsv//eng |
653 | a amygdala | |
653 | a SSRIs | |
653 | a placebo | |
653 | a SAD | |
653 | a subregions | |
653 | a PET | |
653 | a Neuroscience | |
653 | a Neurovetenskap | |
700 | 1 | a Appel, Lieuweu Uppsala universitet,Enheten för nuklearmedicin och PET,Department of Nuclear Medicine and PET, Uppsala University, Uppsala University Hospital, Uppsala, Sweden4 aut0 (Swepub:uu)lap02157 |
700 | 1 | a Åhs, Fredriku Uppsala universitet,Institutionen för psykologi,Department of Psychology and Neuroscience, Duke University, Durham, NC, USA,Department of Psychology and Neuroscience, Duke University, Durham, NC, United States4 aut0 (Swepub:miun)freahs |
700 | 1 | a Linnman, Clasu P.A.I.N. Group, Department of Anesthesia, Children's Hospital, Boston, MA, USA,P.A.I.N. Group, Department of Anesthesia, Childrens Hospital, Boston, MA, United States4 aut |
700 | 1 | a Pissiota, Annau Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut |
700 | 1 | a Frans, Örjanu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)orjafran |
700 | 1 | a Bani, Massimou GlaxoSmithKline, Medicine Research Centre, Verona, Italy4 aut |
700 | 1 | a Bettica, Paolou GlaxoSmithKline, Medicine Research Centre, Verona, Italy4 aut |
700 | 1 | a M Pich, Emiliou GlaxoSmithKline, Medicine Research Centre, Verona, Italy; F. Hoffman la Roche, Pharmaceutical Division, PRED, Basel, Switzerland4 aut |
700 | 1 | a Jacobsson, Evau Uppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden4 aut |
700 | 1 | a Wahlsted, Kurtu Uppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden4 aut |
700 | 1 | a Fredrikson, Matsu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)matsfred |
700 | 1 | a Furmark, Tomasu Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)tomafurm |
710 | 2 | a Uppsala universitetb Institutionen för psykologi4 org |
773 | 0 | t Neuropsychopharmacologyd : Nature Publishing Groupg 37:10, s. 2222-2232q 37:10<2222-2232x 0893-133Xx 1740-634X |
856 | 4 | u https://www.nature.com/articles/npp201272.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181544 |
856 | 4 8 | u https://doi.org/10.1038/npp.2012.72 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38898 |
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