Sökning: WFRF:(Agnati L) > Intramembrane recep...
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000 | 05360naa a2200721 4500 | |
001 | oai:DiVA.org:su-20861 | |
003 | SwePub | |
008 | 081029s2007 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:12137454 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-208612 URI |
024 | 7 | a https://doi.org/10.1007/s00702-006-0589-02 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:121374542 URI |
040 | a (SwePub)sud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fuxe, K.u Karolinska Institutet4 aut |
245 | 1 0 | a Intramembrane receptor-receptor interactions: a novel principle in molecular medicine |
264 | c 2006-10-27 | |
264 | 1 | b Springer Science and Business Media LLC,c 2007 |
338 | a print2 rdacarrier | |
520 | a In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor-receptor interactions and presented the first experimental observations for their existence in crude membrane preparations. The second step was their introduction of the receptor mosaic hypothesis of the engram in 1982. The third step was their proposal that the existence of intramembrane receptor-receptor interactions made possible the integration of synaptic (WT) and extrasynaptic (VT) signals. With the discovery of the intramembrane receptor-receptor interactions with the likely formation of receptor aggregates of multiple receptors, so called receptor mosaics, the entire decoding process becomes a branched process already at the receptor level in the surface membrane. Recent developments indicate the relevance of cooperativity in intramembrane receptor-receptor interactions namely the presence of regulated cooperativity via receptor-receptor interactions in receptor mosaics (RM) built up of the same type of receptor (homo-oligomers) or of subtypes of the same receptor (RM type1). The receptor-receptor interactions will to a large extent determine the various conformational states of the receptors and their operation will be dependent on the receptor composition (stoichiometry), the spatial organization (topography) and order of receptor activation in the RM. The biochemical and functional integrative implications of the receptor-receptor interactions are outlined and long-lived heteromeric receptor complexes with frozen RM in various nerve cell systems may play an essential role in learning, memory and retrieval processes. Intramembrane receptor-receptor interactions in the brain have given rise to novel strategies for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 agonists) and depression (galanin receptor antagonists). The A2A/D2, A2A/D3 and A2A/mGluR5 heteromers and heteromeric complexes with their possible participation in different types of RM are described in detail, especially in the cortico-striatal glutamate synapse and its extrasynaptic components, together with a postulated existence of A2A/D4 heteromers. Finally, the impact of intramembrane receptor-receptor interactions in molecular medicine is discussed outside the brain with focus on the endocrine, the cardiovascular and the immune systems. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng |
653 | a A2A receptors | |
653 | a D2-like receptors | |
653 | a metabotropic glutamate receptor 5 | |
653 | a neuropeptide receptors | |
653 | a receptor heteromers | |
653 | a receptor mosaics | |
653 | a basal ganglia | |
653 | a novel treatment strategies in neuropsychopharmacology | |
653 | a learning and memory | |
653 | a Neurochemistry | |
653 | a Neurokemi | |
653 | a Neurophysiology | |
653 | a Neurofysiologi | |
700 | 1 | a Canals, M.4 aut |
700 | 1 | a Torvinen, M.4 aut |
700 | 1 | a Marcellino, D.u Karolinska Institutet4 aut |
700 | 1 | a Terasmaa, A.4 aut |
700 | 1 | a Genedani, S.4 aut |
700 | 1 | a Leo, G.4 aut |
700 | 1 | a Guidolin, D.4 aut |
700 | 1 | a Diaz-Cabiale, Z.4 aut |
700 | 1 | a Rivera, A.4 aut |
700 | 1 | a Lundström, L.u Stockholms universitet,Institutionen för neurokemi4 aut |
700 | 1 | a Langel, Ülou Stockholms universitet,Institutionen för neurokemi4 aut0 (Swepub:su)ulo |
700 | 1 | a Narvaez, J.4 aut |
700 | 1 | a Tanganelli, S.4 aut |
700 | 1 | a Lluis, C.4 aut |
700 | 1 | a Ferré, S.4 aut |
700 | 1 | a Woods, A.4 aut |
700 | 1 | a Franco, R.4 aut |
700 | 1 | a Agnati, L. F.4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurokemi4 org |
773 | 0 | t Journal of neural transmissiond : Springer Science and Business Media LLCg 114:1, s. 49-75q 114:1<49-75x 0300-9564x 1435-1463 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-20861 |
856 | 4 8 | u https://doi.org/10.1007/s00702-006-0589-0 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:12137454 |
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