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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005360naa a2200721 4500
001oai:DiVA.org:su-20861
003SwePub
008081029s2007 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:12137454
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-208612 URI
0247 a https://doi.org/10.1007/s00702-006-0589-02 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:121374542 URI
040 a (SwePub)sud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Fuxe, K.u Karolinska Institutet4 aut
2451 0a Intramembrane receptor-receptor interactions: a novel principle in molecular medicine
264 c 2006-10-27
264 1b Springer Science and Business Media LLC,c 2007
338 a print2 rdacarrier
520 a In 1980/81 Agnati and Fuxe introduced the concept of intramembrane receptor-receptor interactions and presented the first experimental observations for their existence in crude membrane preparations. The second step was their introduction of the receptor mosaic hypothesis of the engram in 1982. The third step was their proposal that the existence of intramembrane receptor-receptor interactions made possible the integration of synaptic (WT) and extrasynaptic (VT) signals. With the discovery of the intramembrane receptor-receptor interactions with the likely formation of receptor aggregates of multiple receptors, so called receptor mosaics, the entire decoding process becomes a branched process already at the receptor level in the surface membrane. Recent developments indicate the relevance of cooperativity in intramembrane receptor-receptor interactions namely the presence of regulated cooperativity via receptor-receptor interactions in receptor mosaics (RM) built up of the same type of receptor (homo-oligomers) or of subtypes of the same receptor (RM type1). The receptor-receptor interactions will to a large extent determine the various conformational states of the receptors and their operation will be dependent on the receptor composition (stoichiometry), the spatial organization (topography) and order of receptor activation in the RM. The biochemical and functional integrative implications of the receptor-receptor interactions are outlined and long-lived heteromeric receptor complexes with frozen RM in various nerve cell systems may play an essential role in learning, memory and retrieval processes. Intramembrane receptor-receptor interactions in the brain have given rise to novel strategies for treatment of Parkinson's disease (A2A and mGluR5 receptor antagonists), schizophrenia (A2A and mGluR5 agonists) and depression (galanin receptor antagonists). The A2A/D2, A2A/D3 and A2A/mGluR5 heteromers and heteromeric complexes with their possible participation in different types of RM are described in detail, especially in the cortico-striatal glutamate synapse and its extrasynaptic components, together with a postulated existence of A2A/D4 heteromers. Finally, the impact of intramembrane receptor-receptor interactions in molecular medicine is discussed outside the brain with focus on the endocrine, the cardiovascular and the immune systems.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653 a A2A receptors
653 a D2-like receptors
653 a metabotropic glutamate receptor 5
653 a neuropeptide receptors
653 a receptor heteromers
653 a receptor mosaics
653 a basal ganglia
653 a novel treatment strategies in neuropsychopharmacology
653 a learning and memory
653 a Neurochemistry
653 a Neurokemi
653 a Neurophysiology
653 a Neurofysiologi
7001 a Canals, M.4 aut
7001 a Torvinen, M.4 aut
7001 a Marcellino, D.u Karolinska Institutet4 aut
7001 a Terasmaa, A.4 aut
7001 a Genedani, S.4 aut
7001 a Leo, G.4 aut
7001 a Guidolin, D.4 aut
7001 a Diaz-Cabiale, Z.4 aut
7001 a Rivera, A.4 aut
7001 a Lundström, L.u Stockholms universitet,Institutionen för neurokemi4 aut
7001 a Langel, Ülou Stockholms universitet,Institutionen för neurokemi4 aut0 (Swepub:su)ulo
7001 a Narvaez, J.4 aut
7001 a Tanganelli, S.4 aut
7001 a Lluis, C.4 aut
7001 a Ferré, S.4 aut
7001 a Woods, A.4 aut
7001 a Franco, R.4 aut
7001 a Agnati, L. F.4 aut
7102 a Karolinska Institutetb Institutionen för neurokemi4 org
7730 t Journal of neural transmissiond : Springer Science and Business Media LLCg 114:1, s. 49-75q 114:1<49-75x 0300-9564x 1435-1463
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-20861
8564 8u https://doi.org/10.1007/s00702-006-0589-0
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:12137454

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