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Metabolite Changes ...
Metabolite Changes After Metabolic Surgery – Associations to Parameters Reflecting Glucose Homeostasis and Lipid Levels
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- Ahlin, Sofie, 1985 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Cefalo, C. (författare)
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Bondia-Pons, I. (författare)
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Trošt, K. (författare)
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Capristo, E. (författare)
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Marini, L. (författare)
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Romero, M. (författare)
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Zorzano, A. (författare)
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Gastaldelli, A. (författare)
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Mingrone, G. (författare)
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Nolan, J. J. (författare)
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(creator_code:org_t)
- 2021-12-16
- 2021
- Engelska.
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Ingår i: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 12
- Relaterad länk:
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https://www.frontier...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Aims: To test the hypothesis that adipose tissue gene expression patterns would be affected by metabolic surgery and we aimed to identify genes and metabolic pathways as well as metabolites correlating with metabolic changes following metabolic surgery. Materials and Methods: This observational study was conducted at the Obesity Unit at the Catholic University Hospital of the Sacred Heart in Rome, Italy. Fifteen patients, of which six patients underwent Roux-en-Y gastric bypass and nine patients underwent biliopancreatic diversion, were included. The participants underwent an oral glucose tolerance test and a hyperinsulinemic euglycemic clamp. Small polar metabolites were analyzed with a two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC×GC-TOFMS). Gene expression analysis of genes related to metabolism of amino acids and fatty acids were analyzed in subcutaneous adipose tissue. All procedures were performed at study start and at follow-up (after 185.3 ± 72.9 days). Results: Twelve metabolites were significantly changed after metabolic surgery. Six metabolites were identified as 3-indoleacetic acid, 2-hydroxybutyric acid, valine, glutamic acid, 4-hydroxybenzeneacetic acid and alpha-tocopherol. The branched chain amino acids displayed a significant decrease together with a decrease in BCAT1 adipose tissue mRNA levels. Changes in the identified metabolites were associated to changes in lipid, insulin and glucose levels. Conclusions: Our study has identified metabolites and metabolic pathways that are altered by metabolic surgery and may be used as biomarkers for metabolic improvement. Copyright © 2021 Ahlin, Cefalo, Bondia-Pons, Trošt, Capristo, Marini, Romero, Zorzano, Gastaldelli, Mingrone and Nolan.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- adipose tissue
- branched chain amino acids (BCAA)
- metabolic pathway
- metabolic surgery
- metabolomics
- 2 hydroxybutyric acid
- 4 hydroxybenzeneacetic acid
- acetyl coenzyme A carboxylase
- adipophilin
- alpha tocopherol
- amino acid
- aromatic amino acid
- aspartate ammonia ligase
- branched chain amino acid
- C peptide
- diacylglycerol acyltransferase 1
- fatty acid
- fatty acid synthase
- glucose
- glutamate dehydrogenase
- glutamic acid
- glycine amidinotransferase
- hormone sensitive lipase
- indoleacetic acid
- lipid
- messenger RNA
- organic compound
- perilipin 1
- saturated fatty acid
- unclassified drug
- valine
- adult
- amino acid metabolism
- Article
- bariatric surgery
- BCAT1 gene
- BCAT2 gene
- BCKDH alpha
- BCKDH alpha gene
- BCKDH beta gene
- biliopancreatic bypass
- blood sampling
- body mass
- clinical article
- fatty acid metabolism
- female
- follow up
- gene expression
- gene expression profiling
- glucose blood level
- glucose homeostasis
- homeostasis model assessment
- human
- hyperinsulinemic-euglycemic clamp technique
- insulin release
- insulin sensitivity
- lipid level
- male
- mass fragmentography
- metabolic parameters
- metabolite
- observational study
- oral glucose tolerance test
- real time polymerase chain reaction
- RNA isolation
- Roux-en-Y gastric bypass
- time of flight mass spectrometry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Ahlin, Sofie, 19 ...
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Cefalo, C.
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Bondia-Pons, I.
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Trošt, K.
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Capristo, E.
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Marini, L.
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visa fler...
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Romero, M.
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Zorzano, A.
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Gastaldelli, A.
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Mingrone, G.
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Nolan, J. J.
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visa färre...
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Göteborgs universitet