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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004810naa a2200505 4500
001oai:DiVA.org:uu-153606
003SwePub
008110516s2011 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:be083207-7393-4691-84f8-8b53fbdf329d
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1536062 URI
0247 a https://doi.org/10.3109/03009742.2010.5091032 DOI
0247 a https://lup.lub.lu.se/record/18681532 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Nyhäll-Wåhlin, B-M4 aut
2451 0a The presence of rheumatoid nodules at early rheumatoid arthritis diagnosis is a sign of extra-articular disease and predicts radiographic progression of joint destruction over 5 years
264 c 2010-10-05
264 1b Informa UK Limited,c 2011
338 a print2 rdacarrier
520 a OBJECTIVE: Radiographic damage is an important outcome in rheumatoid arthritis (RA). The disease course varies considerably, and there is a need for simple and reliable prognostic markers. The aim of the study was to determine the utility of early signs of extra-articular disease, manifested as rheumatoid nodules (RN), in predicting radiographic outcome. METHODS: In a cohort (n = 1589) of consecutive, newly diagnosed patients with RA, 112 cases with RN at inclusion (7%) were identified. Each case was compared to two age- and sex-matched controls without nodules from the same cohort. Radiographs of the hands and feet were performed at inclusion, after 1, 2, and 5 years and scored according to the modified Sharp van der Heijde Score (SHS; range 0-448). RESULTS: Fifty-two cases with RN and 139 controls without RN had available radiographs at baseline and after 5 years. Cases were more often rheumatoid factor (RF) positive and anti-cyclic citrullinated peptide (anti-CCP) positive, and had higher disease activity and radiographic damage scores at baseline (7.9 vs. 2.5). After 5 years, there was more extensive radiographic damage among the cases (mean SHS progression 21.7 vs. 13.5). In bivariate analysis, positive RF, positive anti-CCP, SHS, and RN were strong baseline predictors for radiographic progression up to 5 years. In multivariate analysis, positive anti-CCP and SHS at baseline were independently associated with radiographic progression. CONCLUSION: The presence of RN at baseline is a marker of extra-articular involvement and severe disease, and a predictor of subsequent joint damage.  
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Rheumatoid arthritis
653 a ACPA
653 a prognosis
653 a Rheumatology
653 a Reumatologi
7001 a Turesson, Carlu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-ctn
7001 a Jacobsson, Lennartu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)orto-lja
7001 a Nilsson, Jan-Åkeu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Enheten för led- och mjukvävnadsforskning,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups,Joint and Soft Tissue Unit4 aut0 (Swepub:lu)med-jnn
7001 a Forslind, K4 aut
7001 a Albertsson, K4 aut
7001 a Rönnelid, Johanu Uppsala universitet,Klinisk immunologi4 aut0 (Swepub:uu)joharonn
7001 a Petersson, Ingemaru Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ipe
7102 a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t Scandinavian journal of rheumatologyd : Informa UK Limitedg 40:2, s. 81-87q 40:2<81-87x 0300-9742x 1502-7732
8564 u https://lup.lub.lu.se/search/files/1996748/1894761.pdf
8564 u https://portal.research.lu.se/files/1996748/1894761.pdfx primaryx freey FULLTEXT
8564 u http://dx.doi.org/10.3109/03009742.2010.509103y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-153606
8564 8u https://doi.org/10.3109/03009742.2010.509103
8564 8u https://lup.lub.lu.se/record/1868153

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