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Increase in Epstein...
Increase in Epstein Barr virus serologies precedes neuroaxonal damage in pre-symptomatic multiple sclerosis
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- Jons, D. (författare)
- University of Gothenburg, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Göteborg, Sweden
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- Bergström, T. (författare)
- University of Gothenburg, Clinical Microbiology, Sahlgrenska University Hospital, Göteborg, Sweden
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- Zetterberg, H. (författare)
- University of Gothenburg, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Dahlgren’s Academy, Göteborg, Sweden
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- Biström, M. (författare)
- Umeå University, Department of Clinical Science, Neurosciences, Umeå, Sweden
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- Alonso-Magdalena, L. (författare)
- Skåne University Hospital, Department of Neurology, Lund, Sweden
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- Gunnarsson, Martin, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology
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- Vrethem, M. (författare)
- Linköping University, Department of Neurology and Department of Clinical and Experimental Medicine, Linköping, Sweden
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- Blennow, K. (författare)
- University of Gothenburg, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Dahlgren’s Academy, Göteborg, Sweden
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- Nilsson, S. (författare)
- University of Gothenburg, Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, Göteborg, Sweden
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- Huang, J. (författare)
- Karolinska Institute, Neuroimmunology Unit, The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Stockholm, Sweden
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- Kockum, I. (författare)
- Karolinska Institute, Neuroimmunology Unit, The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Stockholm, Sweden
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- Olsson, T. (författare)
- Karolinska Institute, Neuroimmunology Unit, The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience, Stockholm, Sweden
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- Waterboer, T. (författare)
- German Cancer Research Center (DKFZ), Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Research Program, Heidelberg, Germany
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- Sundström, P. (författare)
- Umeå University, Department of Clinical Science, Neurosciences, Umeå, Sweden
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- Andersen, O. (författare)
- University of Gothenburg, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Göteborg, Sweden
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(creator_code:org_t)
- Sage Publications, 2022
- 2022
- Engelska.
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Ingår i: Multiple Sclerosis Journal. - : Sage Publications. - 1352-4585 .- 1477-0970. ; 28:Suppl. 3, s. 86-87
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Introduction: Epstein-Barr virus (EBV) infection may be a pre-condition for the development of multiple sclerosis (MS). EBV antibodies, predominantly anti-EBNA1, develop in the presymp-tomatic phase of virtually all MS patients. Using material from a serum repository, studies in advance of MS onset indicated that EBV seropositivity preceded the first expression of incipient axonal lesions, serum Neurofilament Light (sNFL) .Objectives: To determine the onset and individual order of appearance of EBV seroreactivity and the serum neuroaxonal injury marker neurofilament light (sNfL) in a wide age spectrum of presymptomatic MS patients.Aims: To characterize the presymptomatic appearance of anti-bodies against an intranuclear (EBNA1) and a surface EBV anti-gen (gp350) and sNfL.Methods: A nested case-control study in 669 pre-symptomati-cally acquired blood samples from persons who later received an MS diagnosis, and from 1:1 matched control persons. Serum lev-els of EBNA1, VCA and gp350 IgG antibodies and sNFL (n=519) were measured in individual presymptomatic samples and expressed as delta scores with matched controls in relation to time until MS onset.Results: Serum levels expressed as delta scores for anti EBV and NfL IgG showed an incipient increase for anti EBNA1 and gp350 from 15-20 years before MS debut. Significant (p=0.001 and p=0.002) from 10-15 years, with consistent delta-scores succes-sively closer to MS onset. These findings contrasted to the level of sNfL which increasingly diverged from matched controls from 5-10 years before the onset of MS. None of the individual sam-ples negative for both EBNA1 and VCA IgG antibodies in the pre-MS group (n = 36) showed any elevation of the sNfL level.Conclusions: In a pre-MS material, the seroreactivity against EBNA1 was followed by VCA and gp350, before increased sNFL appeared, indicating incipient axonal injury. Together with its biological characteristics this temporal order confirms the role of EBV as a trigger of MS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Jons, D.
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Bergström, T.
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Zetterberg, H.
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Biström, M.
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Alonso-Magdalena ...
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Gunnarsson, Mart ...
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visa fler...
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Vrethem, M.
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Blennow, K.
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Nilsson, S.
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Huang, J.
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Kockum, I.
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Olsson, T.
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Waterboer, T.
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Sundström, P.
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Andersen, O.
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Örebro universitet