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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006221naa a2200685 4500
001oai:DiVA.org:uu-469881
003SwePub
008220318s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:146484408
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4698812 URI
0247 a https://doi.org/10.1111/all.148052 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464844082 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tedner, Sandra G.u Karolinska Institutet4 aut
2451 0a Extract and molecular-based early infant sensitization and associated factors-A PreventADALL study
264 c 2021-05-04
264 1b John Wiley & Sons,c 2021
338 a print2 rdacarrier
520 a Background More knowledge about sensitization patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. Objective We aimed to determine the prevalence and patterns of allergic sensitization at 3 months of age, and explore possible associated factors. Methods From the Scandinavian antenatally recruited PreventADALL mother-child cohort, we included 1110 3-month infants with available serum. Sensitization was defined as s-IgE of >= 0.1 kU(A)/L by Phadiatop Infant(R) (ThermoFisher Scientific) including birch, cat, grass, dog, milk, egg, peanut and wheat. Further ImmunoCAP analyses to ovomucoid, casein, Ara h 1-3, omega-5-gliadin were performed in food extract s-IgE-positive children. Maternal sensitization was defined as s-IgE >= 0.35 kU(A)/L to Phadiatop(R) (inhalant allergen mix) and/or Fx5 (food allergen mix) at 18-week pregnancy. Results Overall 79 (7.3%) infants had specific sensitization, many with low s-IgE-levels (IQR 0.16-0.81 kU(A)/L), with 78 being sensitized to food extract allergens; 41 to egg, 27 to milk, 10 to peanut, and 25 to wheat. A total of 62/78 were further analysed, 18 (29%) had s-IgE to ovomucoid, casein, Ara h 1-3 and/or omega-5-gliadin. Eight infants (0.7%) were sensitized to inhalant allergens. Maternal sensitization to food allergens was associated with infant sensitization, odds ratio 3.64 (95% CI 1.53-8.68). Conclusion Already at 3 months of age, 7% were sensitized to food, mostly without detectable s-IgE to food allergen molecules, and <1% to inhalant allergens. Maternal food sensitization was associated with infants' sensitization.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng
653 a birth cohort
653 a IgE
653 a immunoglobulin E antibodies
653 a molecular allergology
653 a sensitization
7001 a Soderhall, Cillau Karolinska Institutet4 aut
7001 a Konradsen, Jon R.u Karolinska Institutet4 aut
7001 a Bains, Karen E. S.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Borres, Magnus P,d 1956-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)magbo385
7001 a Carlsen, Kai-Hakonu Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Carlsen, Karin C. L.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Fardig, Martinu Karolinska Institutet4 aut
7001 a Gerdin, Sabina W.u Karolinska Institutet4 aut
7001 a Gudmundsdottir, Hrefna K.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Haugen, Guttormu Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Obstet & Gynaecol, Oslo, Norway.4 aut
7001 a Hedlin, Gunillau Karolinska Institutet4 aut
7001 a Jonassen, Christine M.u Ostfold Hosp Trust, Ctr Lab Med, Genet Unit, Kalnes, Norway.;Norwegian Univ Life Sci, Fac Chem Biotechnol & Food Sci, As, Norway.4 aut
7001 a Kreyberg, Inau Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Magi, Caroline-Aleksi O.u Karolinska Institutet4 aut
7001 a Nordhagen, Live S.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;VID Specialized Univ, Oslo, Norway.4 aut
7001 a Rehbinder, Eva M.u Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Dept Dermatol, Oslo, Norway.4 aut
7001 a Rudi, Knutu Norwegian Univ Life Sci, Fac Chem Biotechnol & Food Sci, As, Norway.4 aut
7001 a Skjerven, Havard O.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a Staff, Anne C.u Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Obstet & Gynaecol, Oslo, Norway.4 aut
7001 a Vettukattil, Riyasu Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut
7001 a van Hage, Marianneu Karolinska Institutet4 aut
7001 a Nordlund, Bjornu Karolinska Institutet4 aut
7001 a Asarnoj, Annau Karolinska Institutet4 aut
7102 a Karolinska Institutetb Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 org
7730 t Allergy. European Journal of Allergy and Clinical Immunologyd : John Wiley & Sonsg 76:9, s. 2730-2739q 76:9<2730-2739x 0105-4538x 1398-9995
8564 u https://doi.org/10.1111/all.14805y Fulltext
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14805
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469881
8564 8u https://doi.org/10.1111/all.14805
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:146484408

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