Sökning: WFRF:(Barthel P. D.) > Association of Cere...
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000 | 14806naa a2201921 4500 | |
001 | oai:gup.ub.gu.se/260496 | |
003 | SwePub | |
008 | 240910s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-79268 | |
009 | oai:lup.lub.lu.se:3ab52246-eebe-4f88-8211-9fe063a468a8 | |
009 | oai:prod.swepub.kib.ki.se:137400512 | |
024 | 7 | a https://gup.ub.gu.se/publication/2604962 URI |
024 | 7 | a https://doi.org/10.1001/jamapsychiatry.2017.33912 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-792682 URI |
024 | 7 | a https://lup.lub.lu.se/record/3ab52246-eebe-4f88-8211-9fe063a468a82 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1374005122 URI |
040 | a (SwePub)gud (SwePub)orud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Jansen, Willemijn Ju Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands4 aut |
245 | 1 0 | a Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. |
264 | 1 | b American Medical Association (AMA),c 2018 |
500 | a Funding Agencies:United States Department of Health & Human Services National Institutes of Health (NIH) - USA, NIH National Center for Research Resources (NCRR), Appeared in article as NCRR NIH HHS, Grant number: C06 RR018898United States Department of Health & Human Services National Institutes of Health (NIH) - USA, NIH National Institute on Aging (NIA), Appeared in article as NIA NIH HHS, Grant numbers: R01 AG045611, RF1 AG025516, P50 AG005133, P01 AG026276, P50 AG005681, P01 AG003991, P30 AG010124, P50 AG023501, P01 AG025204 | |
520 | a Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials.To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia.This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study. Normal cognition was defined as having no cognitive concerns for which medical help was sought and scores within the normal range on cognitive tests. Mild cognitive impairment was diagnosed according to published criteria. Study inclusion began in 2013 and is ongoing. Data analysis was performed in January 2017.Global cognitive performance as assessed by the Mini-Mental State Examination (MMSE) and episodic memory performance as assessed by a verbal word learning test. Amyloid aggregation was measured with positron emission tomography or cerebrospinal fluid biomarkers and dichotomized as negative (normal) or positive (abnormal) according to study-specific cutoffs. Generalized estimating equations were used to examine the association between amyloid aggregation and low cognitive scores (MMSE score ≤27 or memory z score≤-1.28) and to assess whether this association was moderated by age, sex, educational level, or apolipoprotein E genotype.Among 2908 persons with normal cognition (mean [SD] age, 67.4 [12.8] years), amyloid positivity was associated with low memory scores after age 70 years (mean difference in amyloid positive vs negative, 4% [95% CI, 0%-7%] at 72 years and 21% [95% CI, 10%-33%] at 90 years) but was not associated with low MMSE scores (mean difference, 3% [95% CI, -1% to 6%], P=.16). Among 4133 patients with MCI (mean [SD] age, 70.2 [8.5] years), amyloid positivity was associated with low memory (mean difference, 16% [95% CI, 12%-20%], P<.001) and low MMSE (mean difference, 14% [95% CI, 12%-17%], P<.001) scores, and this association decreased with age. Low cognitive scores had limited utility for screening of amyloid positivity in persons with normal cognition and those with MCI. In persons with normal cognition, the age-related increase in low memory score paralleled the age-related increase in amyloid positivity with an intervening period of 10 to 15 years.Although low memory scores are an early marker of amyloid positivity, their value as a screening measure for early AD among persons without dementia is limited. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Gerontologi, medicinsk/hälsovetenskaplig inriktning0 (SwePub)305022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Gerontology, specialising in Medical and Health Sciences0 (SwePub)305022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
653 | a amyloid-β | |
653 | a cognitive functioning | |
653 | a No dementia | |
700 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ri1513os |
700 | 1 | a Tijms, Betty Mu Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Fagan, Anne Mu Washington University in St. Louis4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)mphy-ohn |
700 | 1 | a Klunk, William Eu University of Pittsburgh4 aut |
700 | 1 | a van der Flier, Wiesje Mu Amsterdam UMC - Vrije Universiteit Amsterdam4 aut |
700 | 1 | a Villemagne, Victor Lu Austin Health4 aut |
700 | 1 | a Frisoni, Giovanni Bu Centro San Giovanni di Dio Fatebenefratelli4 aut |
700 | 1 | a Fleisher, Adam Su Eli Lilly and Company,University of California, San Diego4 aut |
700 | 1 | a Lleó, Albertou Hospital de Sant Pau4 aut |
700 | 1 | a Mintun, Mark Au Avid Radiopharmaceuticals, Inc4 aut |
700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy4 aut0 (Swepub:gu)xwaand |
700 | 1 | a Engelborghs, Sebastiaanu University of Antwerp4 aut |
700 | 1 | a Na, Duk Lu Sungkyunkwan University4 aut |
700 | 1 | a Chételat, Gäelu Centre Hospitalier Privé Saint-Martin4 aut |
700 | 1 | a Molinuevo, José Luisu Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)4 aut |
700 | 1 | a Landau, Susan Mu University of California, Berkeley4 aut |
700 | 1 | a Mattsson, Niklasu Lund University,Lunds universitet,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)med-nmn |
700 | 1 | a Kornhuber, Johannesu Friedrich-Alexander University Erlangen-Nürnberg4 aut |
700 | 1 | a Sabri, Osamau Leipzig University4 aut |
700 | 1 | a Rowe, Christopher Cu Washington University in St. Louis,Austin Health4 aut |
700 | 1 | a Parnetti, Lucillau University of Perugia4 aut |
700 | 1 | a Popp, Juliusu Lausanne University Hospital4 aut |
700 | 1 | a Fladby, Tormodu Akershus University Hospital4 aut |
700 | 1 | a Jagust, William Ju University of California, Berkeley4 aut |
700 | 1 | a Aalten, Paulineu Maastricht University4 aut |
700 | 1 | a Lee, Dong Youngu Seoul National University4 aut |
700 | 1 | a Vandenberghe, Riku Catholic University of Leuven4 aut |
700 | 1 | a Resende de Oliveira, Catarinau University Hospital of Coimbra4 aut |
700 | 1 | a Kapaki, Elisabethu Eginition Hospital4 aut |
700 | 1 | a Froelich, Lutzu Heidelberg University4 aut |
700 | 1 | a Ivanoiu, Adrianu Saint-Luc University Hospital4 aut |
700 | 1 | a Gabryelewicz, Tomaszu Institute - Center for Molecular and Macromolecular Studies of the Polish Academy of Sciences4 aut |
700 | 1 | a Verbeek, Marcel Mu Radboud University Nijmegen4 aut |
700 | 1 | a Sanchez-Juan, Páscualu University of Cantabria4 aut |
700 | 1 | a Hildebrandt, Helmutu Hospital of Bremen-Ost4 aut |
700 | 1 | a Camus, Vincentu University Of Tours4 aut |
700 | 1 | a Zboch, Marzenau Wrocław Medical University4 aut |
700 | 1 | a Brooks, David Ju Imperial College London4 aut |
700 | 1 | a Drzezga, Alexanderu University of Cologne4 aut |
700 | 1 | a Rinne, Juha Ou Turku PET Centre4 aut |
700 | 1 | a Newberg, Andrewu Thomas Jefferson University4 aut |
700 | 1 | a de Mendonça, Alexandreu University of Lisbon4 aut |
700 | 1 | a Sarazin, Marieu Paris Descartes University4 aut |
700 | 1 | a Rabinovici, Gil Du University of Texas Health Science Centre4 aut |
700 | 1 | a Madsen, Karine4 aut |
700 | 1 | a Kramberger, Milica G4 aut |
700 | 1 | a Nordberg, Agnetau Karolinska Institutet4 aut |
700 | 1 | a Mok, Vincent4 aut |
700 | 1 | a Mroczko, Barbara4 aut |
700 | 1 | a Wolk, David A4 aut |
700 | 1 | a Meyer, Philipp T4 aut |
700 | 1 | a Tsolaki, Magda4 aut |
700 | 1 | a Scheltens, Philip4 aut |
700 | 1 | a Verhey, Frans R J4 aut |
700 | 1 | a Visser, Pieter Jelleu Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands4 aut |
700 | 1 | a Aarsland, Dag4 aut |
700 | 1 | a Alcolea, Daniel4 aut |
700 | 1 | a Alexander, Myriam4 aut |
700 | 1 | a Almdahl, Ina S4 aut |
700 | 1 | a Arnold, Steven E4 aut |
700 | 1 | a Baldeiras, Inês4 aut |
700 | 1 | a Barthel, Henryk4 aut |
700 | 1 | a van Berckel, Bart N M4 aut |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,Sahlgrenska University Hospital4 aut0 (Swepub:lu)med-kbw |
700 | 1 | a van Buchem, Mark A4 aut |
700 | 1 | a Cavedo, Enrica4 aut |
700 | 1 | a Chen, Kewei4 aut |
700 | 1 | a Chipi, Elena4 aut |
700 | 1 | a Cohen, Ann D4 aut |
700 | 1 | a Förster, Stefan4 aut |
700 | 1 | a Fortea, Juan4 aut |
700 | 1 | a Frederiksen, Kristian S4 aut |
700 | 1 | a Freund-Levi, Yvonne,d 1956-u Department of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden,Amyloid Biomarker Study Group4 aut0 (Swepub:oru)yfi |
700 | 1 | a Gkatzima, Olymbia4 aut |
700 | 1 | a Gordon, Mark Forrest4 aut |
700 | 1 | a Grimmer, Timo4 aut |
700 | 1 | a Hampel, Harald4 aut |
700 | 1 | a Hausner, Lucrezia4 aut |
700 | 1 | a Hellwig, Sabine4 aut |
700 | 1 | a Herukka, Sanna-Kaisa4 aut |
700 | 1 | a Johannsen, Peter4 aut |
700 | 1 | a Klimkowicz-Mrowiec, Aleksandra4 aut |
700 | 1 | a Köhler, Sebastian4 aut |
700 | 1 | a Koglin, Norman4 aut |
700 | 1 | a van Laere, Koen4 aut |
700 | 1 | a de Leon, Mony4 aut |
700 | 1 | a Lisetti, Viviana4 aut |
700 | 1 | a Maier, Wolfgang4 aut |
700 | 1 | a Marcusson, Jan4 aut |
700 | 1 | a Meulenbroek, Olga4 aut |
700 | 1 | a Møllergård, Hanne M4 aut |
700 | 1 | a Morris, John C4 aut |
700 | 1 | a Nordlund, Arto,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xnorar |
700 | 1 | a Novak, Gerald P4 aut |
700 | 1 | a Paraskevas, George P4 aut |
700 | 1 | a Perera, Gayan4 aut |
700 | 1 | a Peters, Oliver4 aut |
700 | 1 | a Ramakers, Inez H G B4 aut |
700 | 1 | a Rami, Lorena4 aut |
700 | 1 | a Rodríguez-Rodríguez, Eloy4 aut |
700 | 1 | a Roe, Catherine M4 aut |
700 | 1 | a Rot, Uros4 aut |
700 | 1 | a Rüther, Eckart4 aut |
700 | 1 | a Santana, Isabel4 aut |
700 | 1 | a Schröder, Johannes4 aut |
700 | 1 | a Seo, Sang W4 aut |
700 | 1 | a Sorininen, Hilkka4 aut |
700 | 1 | a Spiru, Luiza4 aut |
700 | 1 | a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-esr |
700 | 1 | a Struyfs, Hanne4 aut |
700 | 1 | a Teunissen, Charlotte E4 aut |
700 | 1 | a Vos, Stephanie J B4 aut |
700 | 1 | a van Waalwijk van Doorn, Linda J C4 aut |
700 | 1 | a Waldemar, Gunhild4 aut |
700 | 1 | a Wallin, Åsa K.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-was |
700 | 1 | a Wiltfang, Jens4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska Academy,Sahlgrenska University Hospital4 aut0 (Swepub:lu)med-hiz |
710 | 2 | a Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlandsb Klinisk minnesforskning4 org |
773 | 0 | t JAMA psychiatryd : American Medical Association (AMA)g 75:1, s. 84-95q 75:1<84-95x 2168-6238x 2168-622X |
856 | 4 | u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2664259/jamapsychiatry_jansen_2017_oi_170081.pdf |
856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156/y Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia |
856 | 4 | u http://dx.doi.org/10.1001/jamapsychiatry.2017.3391y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/260496 |
856 | 4 8 | u https://doi.org/10.1001/jamapsychiatry.2017.3391 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-79268 |
856 | 4 8 | u https://lup.lub.lu.se/record/3ab52246-eebe-4f88-8211-9fe063a468a8 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137400512 |
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