Sökning: WFRF:(Birner A.) > Genome-wide associa...
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000 | 08537naa a2202005 4500 | |
001 | oai:gup.ub.gu.se/239372 | |
003 | SwePub | |
008 | 240910s2016 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:135089540 | |
024 | 7 | a https://gup.ub.gu.se/publication/2393722 URI |
024 | 7 | a https://doi.org/10.1093/hmg/ddw1812 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1350895402 URI |
040 | a (SwePub)gud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hou, Liping4 aut |
245 | 1 0 | a Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder. |
264 | c 2016-06-21 | |
264 | 1 | b Oxford University Press (OUP),c 2016 |
520 | a Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p=5.87×10(-9); odds ratio=1.12) and markers within ERBB2 (rs2517959, p=4.53×10(-9); odds ratio=1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Bergen, Sarah Eu Karolinska Institutet4 aut |
700 | 1 | a Akula, Nirmala4 aut |
700 | 1 | a Song, Jieu Karolinska Institutet4 aut |
700 | 1 | a Hultman, Christina Mu Karolinska Institutet4 aut |
700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
700 | 1 | a Adli, Mazda4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Ardau, Raffaella4 aut |
700 | 1 | a Arias, Bárbara4 aut |
700 | 1 | a Aubry, Jean-Michel4 aut |
700 | 1 | a Backlund, Lenau Karolinska Institutet4 aut |
700 | 1 | a Badner, Judith A4 aut |
700 | 1 | a Barrett, Thomas B4 aut |
700 | 1 | a Bauer, Michael4 aut |
700 | 1 | a Baune, Bernhard T4 aut |
700 | 1 | a Bellivier, Frank4 aut |
700 | 1 | a Benabarre, Antonio4 aut |
700 | 1 | a Bengesser, Susanne4 aut |
700 | 1 | a Berrettini, Wade H4 aut |
700 | 1 | a Bhattacharjee, Abesh Kumar4 aut |
700 | 1 | a Biernacka, Joanna M4 aut |
700 | 1 | a Birner, Armin4 aut |
700 | 1 | a Bloss, Cinnamon S4 aut |
700 | 1 | a Brichant-Petitjean, Clara4 aut |
700 | 1 | a Bui, Elise T4 aut |
700 | 1 | a Byerley, William4 aut |
700 | 1 | a Cervantes, Pablo4 aut |
700 | 1 | a Chillotti, Caterinau Karolinska Institutet4 aut |
700 | 1 | a Cichon, Sven4 aut |
700 | 1 | a Colom, Francesc4 aut |
700 | 1 | a Coryell, William4 aut |
700 | 1 | a Craig, David W4 aut |
700 | 1 | a Cruceanu, Cristiana4 aut |
700 | 1 | a Czerski, Piotr M4 aut |
700 | 1 | a Davis, Tony4 aut |
700 | 1 | a Dayer, Alexandre4 aut |
700 | 1 | a Degenhardt, Franziska4 aut |
700 | 1 | a Del Zompo, Maria4 aut |
700 | 1 | a DePaulo, J Raymond4 aut |
700 | 1 | a Edenberg, Howard J4 aut |
700 | 1 | a Étain, Bruno4 aut |
700 | 1 | a Falkai, Peter4 aut |
700 | 1 | a Foroud, Tatiana4 aut |
700 | 1 | a Forstner, Andreas J4 aut |
700 | 1 | a Frisén, Louiseu Karolinska Institutet4 aut |
700 | 1 | a Frye, Mark A4 aut |
700 | 1 | a Fullerton, Janice M4 aut |
700 | 1 | a Gard, Sébastien4 aut |
700 | 1 | a Garnham, Julie S4 aut |
700 | 1 | a Gershon, Elliot S4 aut |
700 | 1 | a Goes, Fernando S4 aut |
700 | 1 | a Greenwood, Tiffany A4 aut |
700 | 1 | a Grigoroiu-Serbanescu, Maria4 aut |
700 | 1 | a Hauser, Joanna4 aut |
700 | 1 | a Heilbronner, Urs4 aut |
700 | 1 | a Heilmann-Heimbach, Stefanie4 aut |
700 | 1 | a Herms, Stefan4 aut |
700 | 1 | a Hipolito, Maria4 aut |
700 | 1 | a Hitturlingappa, Shashi4 aut |
700 | 1 | a Hoffmann, Per4 aut |
700 | 1 | a Hofmann, Andrea4 aut |
700 | 1 | a Jamain, Stephane4 aut |
700 | 1 | a Jiménez, Esther4 aut |
700 | 1 | a Kahn, Jean-Pierre4 aut |
700 | 1 | a Kassem, Layla4 aut |
700 | 1 | a Kelsoe, John R4 aut |
700 | 1 | a Kittel-Schneider, Sarah4 aut |
700 | 1 | a Kliwicki, Sebastian4 aut |
700 | 1 | a Koller, Daniel L4 aut |
700 | 1 | a König, Barbara4 aut |
700 | 1 | a Lackner, Nina4 aut |
700 | 1 | a Laje, Gonzalo4 aut |
700 | 1 | a Lang, Maren4 aut |
700 | 1 | a Lavebratt, Catharina4 aut |
700 | 1 | a Lawson, William B4 aut |
700 | 1 | a Leboyer, Marion4 aut |
700 | 1 | a Leckband, Susan G4 aut |
700 | 1 | a Liu, Chunyu4 aut |
700 | 1 | a Maaser, Anna4 aut |
700 | 1 | a Mahon, Pamela B4 aut |
700 | 1 | a Maier, Wolfgang4 aut |
700 | 1 | a Maj, Mariou Karolinska Institutet4 aut |
700 | 1 | a Manchia, Mirko4 aut |
700 | 1 | a Martinsson, Linau Karolinska Institutet4 aut |
700 | 1 | a McCarthy, Michael J4 aut |
700 | 1 | a McElroy, Susan L4 aut |
700 | 1 | a McInnis, Melvin G4 aut |
700 | 1 | a McKinney, Rebecca4 aut |
700 | 1 | a Mitchell, Philip B4 aut |
700 | 1 | a Mitjans, Marina4 aut |
700 | 1 | a Mondimore, Francis M4 aut |
700 | 1 | a Monteleone, Palmiero4 aut |
700 | 1 | a Mühleisen, Thomas W4 aut |
700 | 1 | a Nievergelt, Caroline M4 aut |
700 | 1 | a Nöthen, Markus M4 aut |
700 | 1 | a Novák, Tomas4 aut |
700 | 1 | a Nurnberger, John I4 aut |
700 | 1 | a Nwulia, Evaristus A4 aut |
700 | 1 | a Ösby, Urban4 aut |
700 | 1 | a Pfennig, Andrea4 aut |
700 | 1 | a Potash, James B4 aut |
700 | 1 | a Propping, Peter4 aut |
700 | 1 | a Reif, Andreas4 aut |
700 | 1 | a Reininghaus, Eva4 aut |
700 | 1 | a Rice, John4 aut |
700 | 1 | a Rietschel, Marcella4 aut |
700 | 1 | a Rouleau, Guy A4 aut |
700 | 1 | a Rybakowski, Janusz K4 aut |
700 | 1 | a Schalling, Martin4 aut |
700 | 1 | a Scheftner, William A4 aut |
700 | 1 | a Schofield, Peter R4 aut |
700 | 1 | a Schork, Nicholas J4 aut |
700 | 1 | a Schulze, Thomas G4 aut |
700 | 1 | a Schumacher, Johannes4 aut |
700 | 1 | a Schweizer, Barbara W4 aut |
700 | 1 | a Severino, Giovanni4 aut |
700 | 1 | a Shekhtman, Tatyana4 aut |
700 | 1 | a Shilling, Paul D4 aut |
700 | 1 | a Simhandl, Christian4 aut |
700 | 1 | a Slaney, Claire M4 aut |
700 | 1 | a Smith, Erin N4 aut |
700 | 1 | a Squassina, Alessio4 aut |
700 | 1 | a Stamm, Thomas4 aut |
700 | 1 | a Stopkova, Pavla4 aut |
700 | 1 | a Streit, Fabian4 aut |
700 | 1 | a Strohmaier, Jana4 aut |
700 | 1 | a Szelinger, Szabolcs4 aut |
700 | 1 | a Tighe, Sarah K4 aut |
700 | 1 | a Tortorella, Alfonso4 aut |
700 | 1 | a Turecki, Gustavo4 aut |
700 | 1 | a Vieta, Eduard4 aut |
700 | 1 | a Volkert, Julia4 aut |
700 | 1 | a Witt, Stephanie H4 aut |
700 | 1 | a Wright, Adam4 aut |
700 | 1 | a Zandi, Peter P4 aut |
700 | 1 | a Zhang, Peng4 aut |
700 | 1 | a Zollner, Sebastian4 aut |
700 | 1 | a McMahon, Francis J4 aut |
710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi4 org |
773 | 0 | t Human molecular geneticsd : Oxford University Press (OUP)g 25:15, s. 3383-94q 25:15<3383-94x 1460-2083x 0964-6906 |
856 | 4 | u https://academic.oup.com/hmg/article-pdf/25/15/3383/8624729/ddw181.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/239372 |
856 | 4 8 | u https://doi.org/10.1093/hmg/ddw181 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:135089540 |
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