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Melatonin receptors...
Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species
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- Gonzalez-Arto, Marta (författare)
- University of Zaragoza, Spain
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- Vicente Carrillo, Alejandro (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Medicinska fakulteten
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- Martinez-Pastor, Felipe (författare)
- University of Leon, Spain
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- Fernandez-Alegre, Estela (författare)
- University of Leon, Spain
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- Roca, Jordi (författare)
- University of Murcia, Spain
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- Miro, Jordi (författare)
- University of Barcelona, Spain
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- Rigau, Teresa (författare)
- University of Barcelona, Spain
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- Rodriguez-Gil, Joan E. (författare)
- University of Barcelona, Spain
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- Perez-Pe, Rosaura (författare)
- University of Zaragoza, Spain
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- Muino-Blanco, Teresa (författare)
- University of Zaragoza, Spain
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- Cebrian-Perez, Jose A. (författare)
- University of Zaragoza, Spain
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- Casao, Adriana (författare)
- University of Zaragoza, Spain
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2016
- 2016
- Engelska.
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Ingår i: Theriogenology. - : ELSEVIER SCIENCE INC. - 0093-691X .- 1879-3231. ; 86:8, s. 1958-1968
- Relaterad länk:
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https://buleria.unil...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Melatonin is a ubiquitous and multipurpose molecule, and one of its roles is to regulate reproduction in some seasonal mammals. Our group has previously reported the variation in the melatonin levels in ram seminal plasma along the year and identified MT1 and MT2 receptors in ram spermatozoa. The objective of this study was to elucidate whether the presence of melatonin receptors (MT1 and MT2) in the sperm plasma membrane, and melatonin in the seminal plasma is related to seasonal breeding. For this purpose, the presence of melatonin receptors and tseasonal breeder (epididymal spermatozoa); bull as a conventional nonseasonhe levels of melatonin in seminal plasma have been examined in several species: donkey and stallion as long-day breeders; red deer as a wild, short-day, highly al breeder; boar as a seasonal breeder, under management techniques; and dog as possible a seasonal breeder not regulated by melatonin. We have detected measurable levels of melatonin in the seminal plasma of all ejaculated semen samples (from donkey, stallion, boar, bull, and dog). Also, and for the first time, we have demonstrated the presence of MT1 and MT2 melatonin receptors in the spermatozoa of all these species, regardless their type of reproduction or sperm source (ejaculated or epididymal), using indirect immunofluorescence techniques and Western blotting. Our findings suggest that melatonin and melatonin receptors may be universally distributed in the reproductive system of mammals and that the sperm melatonin receptors cells may not be necessarily related with seasonal reproduction. Furthermore, the presence of MT1 at the cytoplasmic droplet in immature ejaculated stallion spermatozoa found in one sample and epididymal red deer spermatozoa suggests that melatonin may be involved in specific functions during spermatogenesis and sperm maturation, like protecting spermatozoa from oxidative damage, this activity being mediated through these receptors. (C) 2016 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Donkey; Stallion; Boar; Bull; Deer; Dog
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gonzalez-Arto, M ...
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Vicente Carrillo ...
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Martinez-Pastor, ...
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Fernandez-Alegre ...
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Roca, Jordi
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Miro, Jordi
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visa fler...
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Rigau, Teresa
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Rodriguez-Gil, J ...
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Perez-Pe, Rosaur ...
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Muino-Blanco, Te ...
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Cebrian-Perez, J ...
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Casao, Adriana
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reproduktionsmed ...
- Artiklar i publikationen
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Theriogenology
- Av lärosätet
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Linköpings universitet