Phenotype, genotype, and antibiotic susceptibility of Swedish and Thai oral isolates of Staphylococcus aureus

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Fältnamn	Indikatorer	Metadata
000		04407naa a2200397 4500
001		oai:gup.ub.gu.se/226762
003		SwePub
008		240528s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2267622 URI
024	7	a https://doi.org/10.3402/jom.v7.262502 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Blomqvist, Susanne,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 34 aut0 (Swepub:gu)xblosu
245	1 0	a Phenotype, genotype, and antibiotic susceptibility of Swedish and Thai oral isolates of Staphylococcus aureus
264		c 2015-04-23
264	1	b Informa UK Limited,c 2015
520		a Objective: The present study investigated phenotypes, virulence genotypes, and antibiotic susceptibility of oral Staphylococcus aureus strains in order to get more information on whether oral infections with this bacterium are associated with certain subtypes or related to an over-growth of the S. aureus variants normally found in the oral cavity of healthy carriers. Materials and methods: A total number of 157 S. aureus strains were investigated. Sixty-two strains were isolated from Swedish adults with oral infections, 25 strains were from saliva of healthy Swedish dental students, and 45 strains were from tongue scrapings of HIV-positive subjects in Thailand, and 25 Thai strains from non-HIV controls. The isolates were tested for coagulase, nitrate, arginine, and hemolysin, and for the presence of the virulence genes: hlg, clfA, can, sdrC, sdrD, sdrE, map/eap (adhesins) and sea, seb, sec, tst, eta, etb, pvl (toxins). MIC90 and MIC50 were determined by E-test against penicillin V, oxacillin, amoxicillin, clindamycin, vancomycin, fusidic acid, and cefoxitin. Results: While the hemolytic phenotype was significantly (p<0.001) more common among the Thai strains compared to Swedish strains, the virulence genes were found in a similar frequency in the S. aureus strains isolated from all four subject groups. The Panton-Valentine leukocidin (PVL) genotype was found in 73-100% of the strains. More than 10% of the strains from Swedish oral infections and from Thai HIVpositives showed low antibiotic susceptibility, most commonly for clindamycin. Only three methicillinresistant S. aureus (MRSA) strains were identified, two from oral infections and one from a Thai HIV patient. Conclusions: S. aureus is occasionally occurring in the oral cavity in both health and disease in Sweden and Thailand. It is therefore most likely that S. aureus in opportunistic oral infections originate from the oral microbiota. S. aureus should be considered in case of oral infections and complaints and the antibiotic susceptibility (including MRSA) should regularly be checked. The frequent presence of S. aureus, although in low numbers among students and staff, emphasizes the importance of standard infection control precautions and of using diagnostic test in the dental clinic. © 2015 Susanne Blomqvist et al.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng
653		a Antibiotic susceptibility
653		a HIV-positive
653		a virulence
653		a Oral infections
653		a Staphylococcus aureus
700	1	a Leonhardt, Åsa,d 1964u Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology4 aut0 (Swepub:gu)xleoas
700	1	a Arirachakaran, P.4 aut
700	1	a Carlén, Anette,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 34 aut0 (Swepub:gu)xcaane
700	1	a Dahlén, Gunnar,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för odontologi, sektion 3,Institute of Odontology, Section 34 aut0 (Swepub:gu)xdahgu
710	2	a Göteborgs universitetb Institutionen för odontologi, sektion 34 org
773	0	t Journal of Oral Microbiologyd : Informa UK Limitedg 7:1, s. 1-7q 7:1<1-7x 2000-2297
856	4	u https://doi.org/10.3402/jom.v7.26250
856	4 8	u https://gup.ub.gu.se/publication/226762
856	4 8	u https://doi.org/10.3402/jom.v7.26250

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