WFRF:(Bruhn Sören)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02703naa a2200277 4500 | |
| 001 | oai:DiVA.org:liu-81990 | |
| 003 | SwePub | |
| 008 | 120927s2006 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-819902 URI |
| 024 | 7 | a https://doi.org/10.1074/jbc.M6013472002 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gasser, Andreasu University Medical Center Hamburg-Eppendorf, Germany4 aut |
| 245 | 1 0 | a Second Messenger Function of Nicotinic Acid Adenine Dinucleotide Phosphate Revealed by an Improved Enzymatic Cycling Assay |
| 264 | 1 | b American Society for Biochemistry and Molecular Biology,c 2006 |
| 338 | a print2 rdacarrier | |
| 520 | a Nicotinic acid adenine dinucleotide phosphate (NAADP) is the most potent activator of Ca2+ release from intracellular stores known today. Although recent reports have suggested an important function of NAADP in human T lymphocytes, direct evidence for receptor-induced formation of NAADP is yet missing in these cells. Thus, we developed a highly sensitive and specific enzyme assay capable of quantifying low fmol amounts of NAADP. In unstimulated T cells, the NAADP concentration amounted to 4.4 +/- 1.6 nm (0.055 +/- 0.028 pmol/mg of protein). Stimulation of the cells via the T cell receptor/CD3 complex resulted in biphasic elevation kinetics of cellular NAADP levels and was characterized by a bell-shaped concentration-response curve for NAADP. In contrast, the NAADP concentration was elevated neither upon activation of the ADP-ribose/TRPM2 channel Ca2+ signaling system nor by an increase of the intracellular Ca2+ concentration upon thapsigargin stimulation. T cell receptor/CD3 complex-mediated NAADP formation was dependent on the activity of tyrosine kinases because genistein completely blocked NAADP elevation. Thus, we propose a regulated formation of NAADP upon specific stimulation of the T cell receptor/CD3 complex, suggesting a function of NAADP as a Ca2+-mobilizing second messenger during T cell activation. | |
| 700 | 1 | a Bruhn, Sören,d 1976-u University Medical Center Hamburg-Eppendorf, Germany4 aut0 (Swepub:liu)sorbr27 |
| 700 | 1 | a Guse, Andreasu University Medical Center Hamburg-Eppendorf, Germany4 aut |
| 710 | 2 | a University Medical Center Hamburg-Eppendorf, Germany4 org |
| 773 | 0 | t Journal of Biological Chemistryd : American Society for Biochemistry and Molecular Biologyg 281:25, s. 16906-16913q 281:25<16906-16913x 0021-9258x 1083-351X |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-81990 |
| 856 | 4 8 | u https://doi.org/10.1074/jbc.M601347200 |
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