Sökning: WFRF:(Donat Vargas Carolina) > Methodological issu...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07427naa a2201093 4500 | |
001 | oai:DiVA.org:umu-154577 | |
003 | SwePub | |
008 | 181219s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140300841 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1545772 URI |
024 | 7 | a https://doi.org/10.1016/j.envres.2018.11.0272 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1403008412 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gasull, Magda4 aut |
245 | 1 0 | a Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort |
264 | 1 | b Elsevier,c 2019 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles.METHODS: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models.RESULTS: There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB.CONCLUSIONS: The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects' characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
653 | a Biomarkers | |
653 | a methods | |
653 | a Disease progression bias | |
653 | a Environmental epidemiology | |
653 | a Lipids | |
653 | a Pancreatic cancer | |
653 | a Persistent organic pollutants | |
700 | 1 | a Pumarega, José4 aut |
700 | 1 | a Kiviranta, Hannu4 aut |
700 | 1 | a Rantakokko, Panu4 aut |
700 | 1 | a Raaschou-Nielsen, Ole4 aut |
700 | 1 | a Bergdahl, Ingvar A.u Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001 |
700 | 1 | a Sandanger, Torkjel Manning4 aut |
700 | 1 | a Goñi, Fernando4 aut |
700 | 1 | a Cirera, Lluís4 aut |
700 | 1 | a Donat-Vargas, Carolinau Karolinska Institutet4 aut |
700 | 1 | a Alguacil, Juan4 aut |
700 | 1 | a Iglesias, Mar4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Mancini, Francesca Romana4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Johnson, Theron4 aut |
700 | 1 | a Kühn, Tilman4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Karakatsani, Anna4 aut |
700 | 1 | a Peppa, Eleni4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Pala, Valeria4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Naccarati, Alessio4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Verschuren, Monique4 aut |
700 | 1 | a Vermeulen, Roel4 aut |
700 | 1 | a Rylander, Charlotta4 aut |
700 | 1 | a Haugdahl Nøst, Therese4 aut |
700 | 1 | a Rodríguez-Barranco, Miguel4 aut |
700 | 1 | a Molinuevo, Amaia4 aut |
700 | 1 | a Chirlaque, María-Dolores4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Sund, Malinu Umeå universitet,Kirurgi,Sund4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Key, Tim4 aut |
700 | 1 | a Ye, Weiminu Karolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm, Sweden4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Michaud, Dominique4 aut |
700 | 1 | a Matullo, Giuseppe4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Nieters, Alexandra4 aut |
700 | 1 | a Nöthlings, Ute4 aut |
700 | 1 | a Jeurnink, Suzanne4 aut |
700 | 1 | a Chajes, Veronique4 aut |
700 | 1 | a Matejcic, Marco4 aut |
700 | 1 | a Gunter, Marc4 aut |
700 | 1 | a Aune, Dagfinn4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Agudo, Antoni4 aut |
700 | 1 | a Gonzalez, Carlos Alberto4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
700 | 1 | a Duell, Eric J.4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Porta, Miquel4 aut |
710 | 2 | a Umeå universitetb Yrkes- och miljömedicin4 org |
773 | 0 | t Environmental Researchd : Elsevierg 169, s. 417-433q 169<417-433x 0013-9351x 1096-0953 |
856 | 4 | u http://diposit.ub.edu/dspace/bitstream/2445/171688/1/GasullM.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154577 |
856 | 4 8 | u https://doi.org/10.1016/j.envres.2018.11.027 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140300841 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy