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Pulmonary function ...
Pulmonary function in children and adolescents after esophageal atresia repair
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- Donoso, Felipe (author)
- Uppsala universitet,Barnkirurgisk forskning,Department of Pediatric Surgery, Uppsala University Children's Hospital, Uppsala, Sweden,Barnkirurgi
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- Hedenström, Hans (author)
- Uppsala universitet,Klinisk fysiologi
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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- Engstrand Lilja, Helene, 1963- (author)
- Uppsala universitet,Barnkirurgisk forskning,Department of Pediatric Surgery, Uppsala University Children's Hospital, Uppsala, Sweden
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(creator_code:org_t)
- 2019-09-18
- 2020
- English.
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In: Pediatric Pulmonology. - : Wiley. - 8755-6863 .- 1099-0496. ; 55:1, s. 206-213
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Abstract
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- IntroductionRespiratory morbidity after esophageal atresia (EA) is common. The aims of this study were to assess pulmonary function, to identify risk factors for pulmonary function impairment (PFI), and to investigate the relations between respiratory morbidity, defined as medical treatment for respiratory symptoms or recent pneumonia and PFI after EA repair.Material and MethodsSingle center retrospective observational study including patients with EA who participated in the follow‐up program for 8‐ or 15‐year old patients from 2014 to 2018 and performed pulmonary function testing by body plethysmography, dynamic spirometry, impulse oscillometry, and diffusing capacity of the lungs. Univariate and multiple stepwise logistic regression with PFI as outcome were performed. Anastomotic leak, episodes of general anesthesia, extubation day, birth weight, age at follow up, gross classification, and abnormal reflux index were independent variables.ResultsIn total, 47 patients were included. PFI was found in 19 patients (41%) and 16 out of 19 patients (84%) had an obstructive pattern. Respiratory morbidity was found in 23 (52%, NA = 3) of the patients with no correlation to PFI. Birth weight, age at follow‐up, and episodes of general anesthesia were identified as risk factors for PFI.ConclusionRespiratory morbidity and PFI were common in children and adolescents after EA repair. The major component of PFI was obstruction of the airways. The risk for PFI increased with lower birth weight and older age at follow up. The poor correlation between respiratory morbidity and PFI motivates the need of clinical follow up including pulmonary function tests.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Kirurgi, särskilt barnkirurgi
- Pediatric Surgery
Publication and Content Type
- ref (subject category)
- art (subject category)
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