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Reciprocal Coupling...
Reciprocal Coupling in Chemically Fueled Assembly : A Reaction Cycle Regulates Self-Assembly and Vice Versa
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Kriebisch, Brigitte A. K. (författare)
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Jussupow, Alexander (författare)
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Bergmann, Alexander M. (författare)
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Kohler, Fabian (författare)
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Dietz, Hendrik (författare)
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- Kaila, Ville R. I. (författare)
- Stockholms universitet,Institutionen för biokemi och biofysik,University of Munich, Germany
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Boekhoven, Job (författare)
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(creator_code:org_t)
- 2020-11-25
- 2020
- Engelska.
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Ingår i: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 142:49, s. 20837-20844
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In biology, self-assembly of proteins and energy-consuming reaction cycles are intricately coupled. For example, tubulin is activated and deactivated for assembly by a guanosine triphosphate (GTP)-driven reaction cycle, and the emerging microtubules catalyze this reaction cycle by changing the microenvironment of the activated tubulin. Recently, synthetic analogs of chemically fueled assemblies have emerged, but examples in which assembly and reaction cycles are reciprocally coupled remain rare. In this work, we report a peptide that can be activated and deactivated for self-assembly. The emerging assemblies change the microenvironment of their building blocks, which consequently accelerate the rates of building block deactivation and reactivation. We quantitatively understand the mechanisms at play, and we are thus able to tune the catalysis by molecular design of the peptide precursor.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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