Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Joubert, Bonnie R (author): National Institute of Environmental Health Sciences

London, Stephanie J (author): National Institute of Environmental Health Sciences

Prasad, Rashmi B (author): Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki

(creator_code:org_t)

Future Medicine Ltd, 2023
2023
English.
In: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 15:1, s. 39-52

Related links:: http://dx.doi.org/10... (free); show more...; https://lup.lub.lu.s...; https://doi.org/10.2...; show less...

Abstract Subject headings

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.

By the author/editor: Fragoso-Bargas, ...; Page, Christian ...; Joubert, Bonnie ...; London, Stephani ...; Lee-Ødegård, Sin ...; Opsahl, Julia O; show more...; Sletner, Line; Jenum, Anne K; Qvigstad, Elisab ...; Prasad, Rashmi B; Moen, Gunn-Helen; Birkeland, Kåre ...; Sommer, Christin ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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