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Prevalence of sarcopenia in community-dwelling older adults using the updated EWGSOP2 definition according to kidney function and albuminuria The Screening for CKD among Older People across Europe (SCOPE) study

Moreno-Gonzalez, Rafael (författare)
Inst Invest Biomed Bellvitge IDIBELL, Hosp Univ Bellvitge, Cardiovasc Resp & Syst Dis & Cellular Aging Progr, Geriatr Unit,Internal Med Dept,Syst Dis & Ageing, Barcelona, Spain.
Corbella, Xavier (författare)
Inst Invest Biomed Bellvitge IDIBELL, Hosp Univ Bellvitge, Cardiovasc Resp & Syst Dis & Cellular Aging Progr, Geriatr Unit,Internal Med Dept,Syst Dis & Ageing, Barcelona, Spain.;Catalunya Int Univ, Hestia Chair Integrated Hlth & Social Care, Fac Med & Hlth Sci, Barcelona, Spain.
Mattace-Raso, Francesco (författare)
Erasmus MC, Univ Med Ctr Rotterdam, Geriatr Med Sect, Dept Internal Med, Rotterdam, Netherlands.
visa fler...
Tap, Lisanne (författare)
Erasmus MC, Univ Med Ctr Rotterdam, Geriatr Med Sect, Dept Internal Med, Rotterdam, Netherlands.
Sieber, Cornel (författare)
Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med Geriatr, Inst Biomed Aging IBA, Nurnberg, Germany.
Freiberger, Ellen (författare)
Friedrich Alexander Univ Erlangen Nurnberg, Dept Internal Med Geriatr, Inst Biomed Aging IBA, Nurnberg, Germany.
Kostka, Tomasz (författare)
Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland.
Guligowska, Agnieszka (författare)
Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland.
Melzer, Itshak (författare)
Ben Gurion Univ Negev, Dept Phys Therapy, Recanati Sch Community Hlth Profess, Fac Hlth Sci, Beer Sheva, Israel.
Melzer, Yehudit (författare)
Ben Gurion Univ Negev, Dept Phys Therapy, Recanati Sch Community Hlth Profess, Fac Hlth Sci, Beer Sheva, Israel.;Maccabi Hlth Org, Tel Aviv, Israel.
Carlsson, Axel C (författare)
Karolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
Ärnlöv, Johan (författare)
Karolinska Institutet,Högskolan Dalarna,Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.,Medicinsk vetenskap,Uppsala University; Karolinska Institutet
Roller-Wirnsberger, Regina (författare)
Med Univ Graz, Dept Internal Med, Graz, Austria.
Wirnsberger, Gerhard (författare)
Med Univ Graz, Dept Internal Med, Graz, Austria.
Gil, Pedro (författare)
Hosp Clin San Carlos, Geriatr Dept, Martin Lagos S-N, Madrid 28040, Spain.
Martinez, Sara Lainez (författare)
Hosp Clin San Carlos, Geriatr Dept, Martin Lagos S-N, Madrid 28040, Spain.
Fabbietti, Paolo (författare)
IRCCS INRCA, Lab Geriatr Pharmacoepidemiol & Biostat, Via S Margherita 5, I-60124 Ancona, Italy.
Corsonello, Andrea (författare)
IRCCS INRCA, Lab Geriatr Pharmacoepidemiol & Biostat, Via S Margherita 5, I-60124 Ancona, Italy.;Italian Natl Res Ctr Aging IRCCS INRCA, Ancona, Italy.;Italian Natl Res Ctr Aging IRCCS INRCA, Fermo, Italy.;Italian Natl Res Ctr Aging IRCCS INRCA, Cosenza, Italy.
Lattanzio, Fabrizia (författare)
Italian Natl Res Ctr Aging IRCCS INRCA, Ancona, Italy.;Italian Natl Res Ctr Aging IRCCS INRCA, Fermo, Italy.;Italian Natl Res Ctr Aging IRCCS INRCA, Cosenza, Italy.
Formiga, Francesc (författare)
Inst Invest Biomed Bellvitge IDIBELL, Hosp Univ Bellvitge, Cardiovasc Resp & Syst Dis & Cellular Aging Progr, Geriatr Unit,Internal Med Dept,Syst Dis & Ageing, Barcelona, Spain.
visa färre...
Inst Invest Biomed Bellvitge IDIBELL, Hosp Univ Bellvitge, Cardiovasc Resp & Syst Dis & Cellular Aging Progr, Geriatr Unit,Internal Med Dept,Syst Dis & Ageing, Barcelona, Spain Inst Invest Biomed Bellvitge IDIBELL, Hosp Univ Bellvitge, Cardiovasc Resp & Syst Dis & Cellular Aging Progr, Geriatr Unit,Internal Med Dept,Syst Dis & Ageing, Barcelona, Spain.;Catalunya Int Univ, Hestia Chair Integrated Hlth & Social Care, Fac Med & Hlth Sci, Barcelona, Spain. (creator_code:org_t)
2020-10-02
2020
Engelska.
Ingår i: BMC Geriatrics. - : BMC. - 1471-2318. ; 20
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Loss of muscle mass and function may be more pronounced in older adults with chronic kidney disease (CKD) and with albuminuria. Thus, we investigated the prevalence of sarcopenia among community-dwelling older adults according to kidney function and grade of albuminuria. We also explored differences in the prevalence of sarcopenia according to three different equations for the estimation of glomerular filtration rate (eGFR). Methods A cross-sectional analysis of 1420 community-dwelling older adults (>= 75 years old) included in the SCOPE study, a multicenter prospective cohort study, was conducted. Comprehensive geriatric assessment including short physical performance battery (SPPB), handgrip strength test and bioelectrical impedance analysis (BIA) was performed. Sarcopenia was defined using the updated criteria of the European Working Group on Sarcopenia in Older People (EWGSOP2). eGFR was calculated using Berlin Initiative Study (BIS), Chronic Kidney Disease Epidemiological Collaboration (CKD-EPI) and Full Age Spectrum (FAS) equations, and urinary albumin-to-creatinine ratio (ACR) was collected to categorize CKD according to Kidney Disease Improving Global Outcomes guidelines. Results Median age was 79.5 years (77.0-83.0), 804 (56.6%) were women. Using EWGSOP2 definition, 150 (10.6%) participants met diagnostic criteria for sarcopenia. Moreover, 85 (6%) participants had severe sarcopenia. Sarcopenia was more prevalent in participants with more advanced stages of CKD according to BIS eq. (9.6% in stages 1 and 2 and 13.9% in stages 3a, 3b and 4,p = 0.042), and also according to CKD-EPI (9.8% vs. 14.2%, p = 0.042) and FAS although not reaching statistical signification (9.8% vs. 12.7%,p = 0.119). Thus, differences in prevalence are observed among CKD categories as estimated by different equations. Prevalence of sarcopenia was also higher with increasing albuminuria categories: 9.3% in normoalbuminuric, 13.2% in microalbuminuric and 16.8% in macroalbuminuric participants, (p = 0.019). Conclusions Sarcopenia is common among community-dwelling older adults, especially among those with more advanced CKD categories, with prevalence estimates differing slightly depending on the equation used for the estimation of eGFR; as well as among those with higher albuminuria categories.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Older adults
Sarcopenia
Chronic kidney disease
Albuminuria
EWGSOP2
Estimated glomerular filtration rate
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