Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Gonzalez Gay Miguel A.) > Analysis of IRF5 ge...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		03177naa a2200445 4500
001		oai:DiVA.org:uu-102433
003		SwePub
008		090507s2006 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1024332 URI
024	7	a https://doi.org/10.1002/art.222712 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Rueda, Blanca4 aut
245	1 0	a Analysis of IRF5 gene functional polymorphisms in rheumatoid arthritis
264		c 2006
264	1	b Wiley,c 2006
338		a print2 rdacarrier
520		a OBJECTIVE: Recent findings suggest that interferon regulatory factor 5 (IRF-5) may play a crucial role in several cellular processes, including the transcription of genes for inflammatory cytokines. Two genetic variants of the IRF5 gene (rs2004640 in exon 1 and rs2280714 in the 3'-untranslated region) have been shown to exert functional modifications affecting IRF5 messenger RNA splicing and expression, and have been associated with genetic predisposition to systemic lupus erythematosus (SLE). The aim of this study was to analyze the possible contribution of the IRF5 gene to the predisposition to rheumatoid arthritis (RA). METHODS: Three case-control cohorts from Spain (724 RA patients and 542 healthy controls), Sweden (281 RA patients 474 healthy controls), and Argentina (284 RA patients and 286 healthy controls) were independently analyzed. Genotyping for IRF5 rs2004640 and rs2280714 was performed using a TaqMan 5' allele-discrimination assay. RESULTS: In the 3 cohorts studied, no statistically significant differences in allele or genotype frequencies of the rs2004640 and rs2280714 IRF5 polymorphisms were observed between RA patients and controls. Accordingly, haplotype analysis revealed that none of the IRF5 haplotypes was associated with genetic predisposition to RA. CONCLUSION: Our results suggest that the IRF5 functional polymorphisms analyzed do not seem to be implicated in genetic susceptibility to RA.
653		a MEDICINE
653		a MEDICIN
700	1	a Reddy, M. V. Prasad Lingau Uppsala universitet,Institutionen för genetik och patologi4 aut
700	1	a González-Gay, Miguel A.4 aut
700	1	a Balsa, Alejandro4 aut
700	1	a Pascual-Salcedo, Dora4 aut
700	1	a Petersson, Ingemar F.4 aut
700	1	a Eimon, Alicia4 aut
700	1	a Paira, Sergio4 aut
700	1	a Scherbarth, Hugo R.4 aut
700	1	a Pons-Estel, Bernardo A.4 aut
700	1	a González-Escribano, Maria F.4 aut
700	1	a Alarcón-Riquelme, Marta E.u Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)martaala
700	1	a Martín, Javier4 aut
710	2	a Uppsala universitetb Institutionen för genetik och patologi4 org
773	0	t Arthritis and Rheumatismd : Wileyg 54:12, s. 3815-3819q 54:12<3815-3819x 0004-3591x 1529-0131
856	4	u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.22271
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-102433
856	4 8	u https://doi.org/10.1002/art.22271

Hitta via bibliotek

Arthritis and Rheumatism (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Rueda, Blanca; Reddy, M. V. Pra ...; González-Gay, Mi ...; Balsa, Alejandro; Pascual-Salcedo, ...; Petersson, Ingem ...; visa fler...; Eimon, Alicia; Paira, Sergio; Scherbarth, Hugo ...; Pons-Estel, Bern ...; González-Escriba ...; Alarcón-Riquelme ...; Martín, Javier; visa färre...

Artiklar i publikationen: Arthritis and Rh ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se