Sökning: WFRF:(Gustafsson Ida) > High-sensitivity tr...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06680naa a2200685 4500 | |
001 | oai:DiVA.org:uu-374939 | |
003 | SwePub | |
008 | 190124s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3749392 URI |
024 | 7 | a https://doi.org/10.1016/j.ijcard.2018.10.0792 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aimo, Albertou Scuola Super Sant Anna, Pisa, Italy4 aut |
245 | 1 0 | a High-sensitivity troponin T, NT-proBNP and glomerular filtration rate :b A multimarker strategy for risk stratification in chronic heart failure |
264 | 1 | b Elsevier BV,c 2019 |
338 | a print2 rdacarrier | |
520 | a Background: In a recent individual patient data meta-analysis, high-sensitivity troponin T (hs-TnT) emerged as robust predictor of prognosis in stable chronic heart failure (HF). In the same population, we compared the relative predictive performances of hs-TnT, N-terminal fraction of pro-B-type natriuretic peptide (NT-proBNP), hs-C-reactive protein (hs-CRP), and estimated glomerular filtration rate (eGFR) for prognosis.Methods and results: 9289 patients (66 ± 12 years, 77% men, 85% LVEF <40%, 60% ischemic HF) were evaluated over a 2.4-year median follow-up. Median eGFR was 58 mL/min/1.73 m2 (interquartile interval 46–70; n = 9220), hs-TnT 16 ng/L (8–20; n = 9289), NT-proBNP 1067 ng/L (433–2470; n = 8845), and hs-CRP 3.3 mg/L (1.4–7.8; n = 7083). In a model including all 3 biomarkers, only hs-TnT and NT-proBNP were independent predictors of all-cause and cardiovascular mortality and cardiovascular hospitalization. hs-TnT was a stronger predictor than NT-proBNP: for example, the risk for all-cause death increased by 54% per doubling of hs-TnT vs. 24% per doubling of NT-proBNP. eGFR showed independent prognostic value from both hs-TnT and NT-proBNP. The best hs-TnT and NT-proBNP cut-offs for the prediction of all-cause death increased progressively with declining renal function (eGFR ≥ 90: hs-TnT 13 ng/L and NT-proBNP 825 ng/L; eGFR < 30: hs-TnT 40 ng/L and NT-proBNP 4608 ng/L). Patient categorization according to these cut-offs effectively stratified patient prognosis across all eGFR classes.Conclusions: hs-TnT conveys independent prognostic information from NT-proBNP, while hs-CRP does not. Concomitant assessment of eGFR may further refine risk stratification. Patient classification according to hs-TnT and NT-proBNP cut-offs specific for the eGFR classes holds prognostic significance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Heart failure | |
653 | a Prognosis | |
653 | a Renal function | |
653 | a Troponin | |
700 | 1 | a Januzzi, James L.,c Jru Massachusetts Gen Hosp, Harvard Clin Res Inst, Boston, MA USA4 aut |
700 | 1 | a Vergaro, Giuseppeu Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy4 aut |
700 | 1 | a Ripoli, Andreau Fdn Toscana G Monasterio, Pisa, Italy4 aut |
700 | 1 | a Latini, Robertou IRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy4 aut |
700 | 1 | a Masson, Sergeu IRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy4 aut |
700 | 1 | a Magnoli, Michelau IRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy4 aut |
700 | 1 | a Anand, Inder S.u Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA; VA Med Ctr, Dept Cardiol, Minneapolis, MN USA4 aut |
700 | 1 | a Cohn, Jay Nu Univ Minnesota, Div Cardiovasc Med, Minneapolis, MN USA4 aut |
700 | 1 | a Tavazzi, Luigiu ES Hlth Sci Fdn, GVM Hosp Care & Res, Cotignola, Italy4 aut |
700 | 1 | a Tognoni, Gianniu IRCCS Ist Ric Farmacol Mario Negri, Dept Cardiovasc Res, Milan, Italy4 aut |
700 | 1 | a Gravning, Jørgenu Oslo Univ Hosp, Dept Cardiol, Oslo, Norway; Univ Oslo, Ctr Heart Failure Res, Oslo, Norway4 aut |
700 | 1 | a Ueland, Thoru Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Oslo, Norway; Univ Oslo, Fac Med, Oslo, Norway; Univ Tromso, KG Jebsen Thrombosis Res & Expertise Ctr, Tromso, Norway4 aut |
700 | 1 | a Nymo, Ståle Hu Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Oslo, Norway4 aut |
700 | 1 | a Rocca, Hans-Peter Brunner-Lau Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherland4 aut |
700 | 1 | a Bayes-Genis, Antoniu Hosp Badalona Germans Trias & Pujol, Barcelona, Spain4 aut |
700 | 1 | a Lupón, Josepu Hosp Badalona Germans Trias & Pujol, Barcelona, Spain4 aut |
700 | 1 | a de Boer, Rudolf A.u Univ Med Ctr Groningen, Groningen, Netherlands4 aut |
700 | 1 | a Yoshihisa, Akiomiu Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan4 aut |
700 | 1 | a Takeishi, Yasuchikau Fukushima Med Univ, Dept Cardiovasc Med, Fukushima, Japan4 aut |
700 | 1 | a Egstrup, Michaelu Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark4 aut |
700 | 1 | a Gustafsson, Idau Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark4 aut |
700 | 1 | a Gaggin, Hanna K.u Massachusetts Gen Hosp, Harvard Clin Res Inst, Boston, MA USA4 aut |
700 | 1 | a Eggers, Kai M.,d 1962-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)kaieg561 |
700 | 1 | a Huber, Kurtu Wilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria4 aut |
700 | 1 | a Tentzeris, Ioannisu Wilhelminenspital Stadt Wien, Fac Internal Med, Vienna, Austria; Sigmund Freud Univ, Med Sch, Vienna, Austria4 aut |
700 | 1 | a Wilson Tang, W. H.u Cleveland Clin, Heart & Vasc Inst, Cleveland, OH USA4 aut |
700 | 1 | a Grodin, Justin Lu Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Div Cardiol, Dallas, TX USA4 aut |
700 | 1 | a Passino, Claudiou Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy4 aut |
700 | 1 | a Emdin, Micheleu Scuola Super Sant Anna, Pisa, Italy; Fdn Toscana G Monasterio, Pisa, Italy4 aut |
710 | 2 | a Scuola Super Sant Anna, Pisa, Italyb Massachusetts Gen Hosp, Harvard Clin Res Inst, Boston, MA USA4 org |
773 | 0 | t International Journal of Cardiologyd : Elsevier BVg 277, s. 166-172q 277<166-172x 0167-5273x 1874-1754 |
856 | 4 | u https://pure.rug.nl/ws/files/78167601/biomarkers_prognosis_M214_01.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374939 |
856 | 4 8 | u https://doi.org/10.1016/j.ijcard.2018.10.079 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.