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Sökning: WFRF:(Gustafsson Susanne) > (2020-2024) > A validated search ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004792naa a2200493 4500
001oai:DiVA.org:kth-278785
003SwePub
008200729s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144129411
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2787852 URI
0247 a https://doi.org/10.1016/j.envint.2020.1058282 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1441294112 URI
040 a (SwePub)kthd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Escriva, Laurau Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Univ Valencia, Fac Pharm, Lab Food Chem & Toxicol, Burjassot, Spain.4 aut
2451 0a A validated search filter for the identification of endocrine disruptors based on the ECHA/EFSA guidance recommendations
264 1b Elsevier BV,c 2020
338 a print2 rdacarrier
500 a QC 20200729
520 a A guidance document for the identification of endocrine disruptors (EDs) in the regulatory assessment of plant protection products (PPP) and biocidal products (BP) has been published by the European Chemical Agency (ECHA) and the European Food Safety Authority (EFSA). The ECHA/EFSA guidance, mainly addressing EATS (estrogen, androgen, thyroid, steroidogenesis) modalities, is intended to guide applicants and assessors of the competent regulatory authorities on the implementation of the scientific criteria for the determination of ED properties pursuant to the recently implemented PPP (EU 2018/605) and BP (EU 2017/2100 ) EU Regulations. In this study, a search filter for targeted literature search in context of assessing if a substance can be identified as an ED relevant for human health was developed and validated. Development of the search filter was based on the search strategy presented in the ECHA/EFSA guidance and using the estrogenic chemical Bisphenol AF (BPAF) as a model substance. Information specialists from two independent institutions developed refined search filters based on the suggested original search strategy published (ECHA/EFSA guidance - Appendix F). Articles identified by a systematic literature search for BPAF were screened for relevance with inclusion and exclusion criteria by two independent reviewers obtaining positive (relevant) and negative (irrelevant) controls. The developed search filter was quantitatively evaluated in terms of sensitivity, specificity and precision based on the positive and negative controls. The developed filter was then validated for T modality by its application to the known thyroid-disruptor perchlorate. The result is a sensitive search filter with sufficient specificity, which can be applied for all chemicals where a targeted literature search is needed to assess and identify ED properties of chemicals with relevance for humans. Future application of the filter to a broader range of chemicals may identify further points of improvement.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Annan medicin och hälsovetenskapx Övrig annan medicin och hälsovetenskap0 (SwePub)305992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Other Medical and Health Sciencesx Other Medical and Health Sciences not elsewhere specified0 (SwePub)305992 hsv//eng
650 7a SAMHÄLLSVETENSKAPx Medie- och kommunikationsvetenskapx Biblioteks- och informationsvetenskap0 (SwePub)508052 hsv//swe
650 7a SOCIAL SCIENCESx Media and Communicationsx Information Studies0 (SwePub)508052 hsv//eng
653 a Endocrine disruptors
653 a ED assessment
653 a ED criteria
653 a Search filter
653 a Systematic literature search
7001 a Hessel, Ellenu Natl Inst Publ Hlth & Environm RIVM, Utrecht, Netherlands.4 aut
7001 a Gustafsson, Susanneu Swedish Med Prod Agcy, Uppsala, Sweden.4 aut
7001 a van Spronsen, Robu Natl Inst Publ Hlth & Environm RIVM, Utrecht, Netherlands.4 aut
7001 a Svanberg, Magdalenau KTH,Bibliotek4 aut0 (Swepub:kth)u197hl8k
7001 a Beronius, Annau Karolinska Institutet4 aut
7102 a Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Univ Valencia, Fac Pharm, Lab Food Chem & Toxicol, Burjassot, Spain.b Natl Inst Publ Hlth & Environm RIVM, Utrecht, Netherlands.4 org
7730 t Environment Internationald : Elsevier BVg 142q 142x 0160-4120x 1873-6750
8564 u https://doi.org/10.1016/j.envint.2020.105828y Fulltext
8564 u https://doi.org/10.1016/j.envint.2020.105828
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278785
8564 8u https://doi.org/10.1016/j.envint.2020.105828
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144129411

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