Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype.

Keyword

Amino Acid Substitution

Animals

Aorta; Thoracic/pathology/ultrastructure

Behavior; Animal

Blotting; Western

CADASIL/*genetics

Carotid Artery; Common/pathology/ultrastructure

Comparative Study

Cysteine/metabolism

Germ-Line Mutation

Magnetic Resonance Imaging

Male

Mice

Mice; Mutant Strains

Phenotype

Polymerase Chain Reaction

Proto-Oncogene Proteins/*genetics

Receptors; Cell Surface/*genetics

Receptors; Notch

Research Support; Non-U.S. Gov't

Sequence Analysis; DNA

Thoracic Vertebrae/ultrasonography

Publication and Content Type

ref (subject category)

art (subject category)