Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

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Fältnamn	Indikatorer	Metadata
000		10089naa a2202017 4500
001		oai:DiVA.org:uu-430992
003		SwePub
008		210113s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:bc488d97-e864-4b86-9d56-0c5c664df209
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4309922 URI
024	7	a https://doi.org/10.1016/j.kint.2020.09.0302 DOI
024	7	a https://lup.lub.lu.se/record/bc488d97-e864-4b86-9d56-0c5c664df2092 URI
040		a (SwePub)uud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Gorski, Mathiasu University Hospital Regensburg,University of Regensburg4 aut
245	1 0	a Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
264	1	b Elsevier,c 2021
338		a electronic2 rdacarrier
520		a Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a Genome-wide association study
653		a acute kidney injury
653		a end-stage kidney disease
653		a rapid eGFRcrea decline
653		a Genome-wide association study; acute kidney injury; end-stage kidney disease; rapid eGFRcrea decline.
700	1	a Jung, Bettina4 aut
700	1	a Li, Yong4 aut
700	1	a Matias-Garcia, Pamela R.4 aut
700	1	a Wuttke, Matthias4 aut
700	1	a Coassin, Stefan4 aut
700	1	a Thio, Chris H. L.4 aut
700	1	a Kleber, Marcus E.4 aut
700	1	a Winkler, Thomas W.4 aut
700	1	a Wanner, Veronika4 aut
700	1	a Chai, Jin-Fang4 aut
700	1	a Chu, Audrey Y.4 aut
700	1	a Cocca, Massimiliano4 aut
700	1	a Feitosa, Mary F.4 aut
700	1	a Ghasemi, Sahar4 aut
700	1	a Hoppmann, Anselm4 aut
700	1	a Horn, Katrin4 aut
700	1	a Li, Man4 aut
700	1	a Nutile, Teresa4 aut
700	1	a Scholz, Markus4 aut
700	1	a Sieber, Karsten B.4 aut
700	1	a Teumer, Alexander4 aut
700	1	a Tin, Adrienne4 aut
700	1	a Wang, Judy4 aut
700	1	a Tayo, Bamidele O.4 aut
700	1	a Ahluwalia, Tarunveer S.4 aut
700	1	a Almgren, Peteru Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Diabetes - kardiovaskulär sjukdom,Kardiovaskulär forskning - hypertoni,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Diabetes - Cardiovascular Disease,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-pal
700	1	a Bakker, Stephan J. L.4 aut
700	1	a Banas, Bernhard4 aut
700	1	a Bansal, Nisha4 aut
700	1	a Biggs, Mary L.4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Bottinger, Erwin P.4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Carroll, Robert J.4 aut
700	1	a Chalmers, John4 aut
700	1	a Chee, Miao-Li4 aut
700	1	a Chee, Miao-Ling4 aut
700	1	a Cheng, Ching-Yu4 aut
700	1	a Coresh, Josef4 aut
700	1	a de Borst, Martin H.4 aut
700	1	a Degenhardt, Frauke4 aut
700	1	a Eckardt, Kai-Uwe4 aut
700	1	a Endlich, Karlhans4 aut
700	1	a Franke, Andre4 aut
700	1	a Freitag-Wolf, Sandra4 aut
700	1	a Gampawar, Piyush4 aut
700	1	a Gansevoort, Ron T.4 aut
700	1	a Ghanbari, Mohsen4 aut
700	1	a Gieger, Christian4 aut
700	1	a Hamet, Pavel4 aut
700	1	a Ho, Kevin4 aut
700	1	a Hofer, Edith4 aut
700	1	a Holleczek, Bernd4 aut
700	1	a Xian Foo, Valencia Hui4 aut
700	1	a Hutri-Kähönen, Nina4 aut
700	1	a Hwang, Shih-Jen4 aut
700	1	a Ikram, M. Arfan4 aut
700	1	a Josyula, Navya Shilpa4 aut
700	1	a Kähönen, Mika4 aut
700	1	a Khor, Chiea-Chuen4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Kramer, Holly4 aut
700	1	a Krämer, Bernhard K.4 aut
700	1	a Kühnel, Brigitte4 aut
700	1	a Lange, Leslie A.4 aut
700	1	a Lehtimäki, Terho4 aut
700	1	a Lieb, Wolfgang4 aut
700	1	a Loos, Ruth J. F.4 aut
700	1	a Lukas, Mary Ann4 aut
700	1	a Lyytikäinen, Leo-Pekka4 aut
700	1	a Meisinger, Christa4 aut
700	1	a Meitinger, Thomas4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Milaneschi, Yuri4 aut
700	1	a Mishra, Pashupati P.4 aut
700	1	a Mononen, Nina4 aut
700	1	a Mychaleckyj, Josyf C.4 aut
700	1	a Nadkarni, Girish N.4 aut
700	1	a Nauck, Matthias4 aut
700	1	a Nikus, Kjell4 aut
700	1	a Ning, Boting4 aut
700	1	a Nolte, Ilja M.4 aut
700	1	a O'Donoghue, Michelle L.4 aut
700	1	a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
700	1	a Pendergrass, Sarah A.4 aut
700	1	a Penninx, Brenda W. J. H.4 aut
700	1	a Preuss, Michael H.4 aut
700	1	a Psaty, Bruce M.4 aut
700	1	a Raffield, Laura M.4 aut
700	1	a Raitakari, Olli T.4 aut
700	1	a Rettig, Rainer4 aut
700	1	a Rheinberger, Myriam4 aut
700	1	a Rice, Kenneth M.4 aut
700	1	a Rosenkranz, Alexander R.4 aut
700	1	a Rossing, Peter4 aut
700	1	a Rotter, Jerome I.4 aut
700	1	a Sabanayagam, Charumathi4 aut
700	1	a Schmidt, Helena4 aut
700	1	a Schmidt, Reinhold4 aut
700	1	a Schöttker, Ben4 aut
700	1	a Schulz, Christina-Alexandra4 aut
700	1	a Sedaghat, Sanaz4 aut
700	1	a Shaffer, Christian M.4 aut
700	1	a Strauch, Konstantin4 aut
700	1	a Szymczak, Silke4 aut
700	1	a Taylor, Kent D.4 aut
700	1	a Tremblay, Johanne4 aut
700	1	a Chaker, Layal4 aut
700	1	a van der Harst, Pim4 aut
700	1	a van der Most, Peter J.4 aut
700	1	a Verweij, Niek4 aut
700	1	a Völker, Uwe4 aut
700	1	a Waldenberger, Melanie4 aut
700	1	a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
700	1	a Waterworth, Dawn M.4 aut
700	1	a White, Harvey D.4 aut
700	1	a Wilson, James G.4 aut
700	1	a Wong, Tien-Yin4 aut
700	1	a Woodward, Mark4 aut
700	1	a Yang, Qiong4 aut
700	1	a Yasuda, Masayuki4 aut
700	1	a Yerges-Armstrong, Laura M.4 aut
700	1	a Zhang, Yan4 aut
700	1	a Snieder, Harold4 aut
700	1	a Wanner, Christoph4 aut
700	1	a Böger, Carsten A.4 aut
700	1	a Köttgen, Anna4 aut
700	1	a Kronenberg, Florian4 aut
700	1	a Pattaro, Cristian4 aut
700	1	a Heid, Iris M.u University of Regensburg4 aut
710	2	a University Hospital Regensburgb University of Regensburg4 org
710	2	a Lifelines Cohort Study
773	0	t Kidney Internationald : Elsevierg 99:4, s. 926-939q 99:4<926-939x 0085-2538x 1523-1755
856	4	u https://doi.org/10.1016/j.kint.2020.09.030y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1517039/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.kidney-international.org/article/S0085253820312394/pdf
856	4	u http://dx.doi.org/10.1016/j.kint.2020.09.030x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-430992
856	4 8	u https://doi.org/10.1016/j.kint.2020.09.030
856	4 8	u https://lup.lub.lu.se/record/bc488d97-e864-4b86-9d56-0c5c664df209

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Av författaren/redakt...: Gorski, Mathias; Jung, Bettina; Li, Yong; Matias-Garcia, P ...; Wuttke, Matthias; Coassin, Stefan; visa fler...; Thio, Chris H. L ...; Kleber, Marcus E ...; Winkler, Thomas ...; Wanner, Veronika; Chai, Jin-Fang; Chu, Audrey Y.; Cocca, Massimili ...; Feitosa, Mary F.; Ghasemi, Sahar; Hoppmann, Anselm; Horn, Katrin; Li, Man; Nutile, Teresa; Scholz, Markus; Sieber, Karsten ...; Teumer, Alexande ...; Tin, Adrienne; Wang, Judy; Tayo, Bamidele O ...; Ahluwalia, Tarun ...; Almgren, Peter; Bakker, Stephan ...; Banas, Bernhard; Bansal, Nisha; Biggs, Mary L.; Boerwinkle, Eric; Bottinger, Erwin ...; Brenner, Hermann; Carroll, Robert ...; Chalmers, John; Chee, Miao-Li; Chee, Miao-Ling; Cheng, Ching-Yu; Coresh, Josef; de Borst, Martin ...; Degenhardt, Frau ...; Eckardt, Kai-Uwe; Endlich, Karlhan ...; Franke, Andre; Freitag-Wolf, Sa ...; Gampawar, Piyush; Gansevoort, Ron ...; Ghanbari, Mohsen; Gieger, Christia ...; Hamet, Pavel; Ho, Kevin; Hofer, Edith; Holleczek, Bernd; Xian Foo, Valenc ...; Hutri-Kähönen, N ...; Hwang, Shih-Jen; Ikram, M. Arfan; Josyula, Navya S ...; Kähönen, Mika; Khor, Chiea-Chue ...; Koenig, Wolfgang; Kramer, Holly; Krämer, Bernhard ...; Kühnel, Brigitte; Lange, Leslie A.; Lehtimäki, Terho; Lieb, Wolfgang; Loos, Ruth J. F.; Lukas, Mary Ann; Lyytikäinen, Leo ...; Meisinger, Chris ...; Meitinger, Thoma ...; Melander, Olle; Milaneschi, Yuri; Mishra, Pashupat ...; Mononen, Nina; Mychaleckyj, Jos ...; Nadkarni, Girish ...; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Nolte, Ilja M.; O'Donoghue, Mich ...; Orho-Melander, M ...; Pendergrass, Sar ...; Penninx, Brenda ...; Preuss, Michael ...; Psaty, Bruce M.; Raffield, Laura ...; Raitakari, Olli ...; Rettig, Rainer; Rheinberger, Myr ...; Rice, Kenneth M.; Rosenkranz, Alex ...; Rossing, Peter; Rotter, Jerome I ...; Sabanayagam, Cha ...; Schmidt, Helena; Schmidt, Reinhol ...; Schöttker, Ben; Schulz, Christin ...; Sedaghat, Sanaz; Shaffer, Christi ...; Strauch, Konstan ...; Szymczak, Silke; Taylor, Kent D.; Tremblay, Johann ...; Chaker, Layal; van der Harst, P ...; van der Most, Pe ...; Verweij, Niek; Völker, Uwe; Waldenberger, Me ...; Wallentin, Lars, ...; Waterworth, Dawn ...; White, Harvey D.; Wilson, James G.; Wong, Tien-Yin; Woodward, Mark; Yang, Qiong; Yasuda, Masayuki; Yerges-Armstrong ...; Zhang, Yan; Snieder, Harold; Wanner, Christop ...; Böger, Carsten A ...; Köttgen, Anna; Kronenberg, Flor ...; Pattaro, Cristia ...; Heid, Iris M.; visa färre...

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