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DAPSA, DAS28 and MD...
DAPSA, DAS28 and MDA predict long-term treatment regime in psoriatic arthritis : The Swedish Early Psoriatic Arthritis Cohort
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- Lindqvist, U., 1948- (författare)
- Uppsala University,Uppsala universitet,Reumatologi
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- Wernroth, M. L. (författare)
- Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Husmark, T. (författare)
- Department of Rheumatology, Falu Hospital, Falun, Sweden,Falun Cent Hosp, Dept Rheumatol, Falu, Sweden.,Falun Central Hospital
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- Larsson, Per (författare)
- Department of Rheumatology, Karolinska University Hospital, Huddinge, Stockholm, Sweden,Karolinska Univ Hosp, Dept Rheumatol, Stockholm, Sweden.
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- Geijer, Mats, 1957- (författare)
- Lund University,Lunds universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Clinical Sciences, Lund University, Lund, Sweden; Department of Radiology, University Hospital, Örebro, Sweden,Lund Univ, Dept Clin Sci, Lund, Sweden.;Univ Hosp, Dept Radiol, Orebro, Sweden.,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Teleman, A. (författare)
- Spenshult Hospital, Spenshult AB, Oskarström, Sweden,Spenshult Hosp, Spenshult AB, Oskarstrom, Sweden.
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- Theander, Elke (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Alenius, Gerd-Marie (författare)
- Umeå University,Umeå universitet,Reumatologi
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(creator_code:org_t)
- Clinical and Experimental Rheumatology, 2017
- 2017
- Engelska.
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Ingår i: Clinical and Experimental Rheumatology. - : Clinical and Experimental Rheumatology. - 0392-856X .- 1593-098X. ; 35:6, s. 936-942
- Relaterad länk:
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http://europepmc.org...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: To describe treatment patterns in the Swedish early psoriatic arthritis cohort (SwePsA) of the mono-/oligo-arthritic (M/O) and polyarthritis (P) and identify early predictive factors for treatment with disease-modifying anti-rheumatic (DMARD), non-steroidal anti-inflammatory drugs (NSAID), and tumour necrosis factor inhibition (TNFi) after 5 years.Methods: Data for 198 M/O and P PsA were obtained within the programme for SwePsA. Multinomial and binary logistic regression analyses were used to assess the association between early predictive factors and treatment after 5 years adjusted for age at inclusion. The analysis of DMARD/NSAID was adjusted for medication at inclusion.Results: After inclusion visit, DMARD was prescribed in 30% of M/O and 56% of P PsA; mainly methotrexate. TNFi was not prescribed at inclusion, but 23 patients were treated at 5-year follow-up. The adjusted OR (95% CI) for treatment with both DMARD and NSAID after 5 years was 3.65 (1.34 - 9.89) (p=0.010) for Disease Activity Score 28 (DAS28) >3.2 and 2.90 (1.20-6.99) (p=0.038) for Disease Activity Index in Psoriatic Arthritis (DAPSA) >14 at inclusion. TNFi treatment was, after adjusting for age, associated with high erythrocyte sedimentation rate (p=0.0043), high C-reactive protein (p=0.013), DAPSA (p<0.001), not reaching minimal disease activity (p=0.001) high health assessment questionnaire (p=0.001), patient's overall assessment on the visual analogue scale (VAS) (p=0.009), high pain VAS (p=0.007), and high number of tender and swollen joints (p=0.031) at inclusion.Conclusion: Disease activity in early M/O and P PsA is to be considered in deciding the level of health care assessment and future pharmacological treatment. DAS28 >3.2 and DAPSA>14 early in the disease predict subsequent treatment with DMARD. For prediction of biological treatment, not reaching MDA at onset of disease, would be the composite index of choice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- DMARD
- NSAID
- TNF-inhibition
- minimal disease activity
- remission
- DMARD
- Minimal disease activity
- NSAID
- Remission
- TNF-inhibition
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Lindqvist, U., 1 ...
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Wernroth, M. L.
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Husmark, T.
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Larsson, Per
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Geijer, Mats, 19 ...
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Teleman, A.
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Theander, Elke
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Alenius, Gerd-Ma ...
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Örebro universitet
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Umeå universitet
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Uppsala universitet
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Lunds universitet