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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004456naa a2200541 4500
001oai:DiVA.org:liu-13161
003SwePub
008080507s2005 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-12938
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-131612 URI
0247 a https://doi.org/10.1093/intimm/dxh3042 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129382 URI
040 a (SwePub)liud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Widhe, Monau Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)monwi58
2451 0a Up-regulation of Borrelia-specific IL-4 and IFN-gamma secreting cells in cerebrospinal fluid from children with Lyme neuroborreliosis
264 c 2005-09-13
264 1b Oxford University Press (OUP),c 2005
338 a print2 rdacarrier
520 a The clinical course and outcome of several infectious diseases are dependent on the type of immune response elicited against the pathogen. In adults with neuroborreliosis (NB), a type 1 response with high production of Borrelia-specific IFN-, but no IL-4, has been reported. Since children have a more benign course of NB than adults, we wanted to investigate type 1 and type 2 responses in children with NB. Cerebrospinal fluid (CSF) and blood were collected from children during the acute stage of ‘confirmed NB’ (n = 34), ‘possible NB’ (n = 30) and ‘non-NB’ (n = 10). The number of Borrelia-specific IL-4- and IFN--secreting cells was measured by enzyme-linked immunospot assay. Borrelia-specific secretion of both IL-4 and IFN- was increased in CSF in confirmed (P < 0.05) and possible (P < 0.01) NB, when compared with non-NB controls. Furthermore, children with NB had significantly higher Borrelia-specific IL-4 secretion in CSF than an adult reference material with NB (P < 0.05). There were no differences in cytokine secretion in relation to onset or recovery of neurological symptoms. Since IL-4 is known to down-regulate the pro-inflammatory and possibly harmful effects of prolonged IFN- responses, the prominent IL-4 response observed in the central nervous system compartment might contribute to the more benign disease course seen in children with Lyme NB.
653 a cytokines
653 a IL-4
653 a IFN-{gamma}
653 a immune response
653 a ELISPOT
653 a MEDICINE
653 a MEDICIN
7001 a Hedin Skogman, Barbrou Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)barhe07
7001 a Bergström, Svenu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Bergström,Department of Microbiology, University of Umeå, Sweden4 aut0 (Swepub:umu)svbe0001
7001 a Forsberg, Piau Linköpings universitet,Infektionsmedicin,Hälsouniversitetet4 aut0 (Swepub:liu)piafo27
7001 a Ernerudh, Janu Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)janer15
7001 a Jarefors, Sarau Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)sarja40
7001 a Eknefelt, Mattiasu Pediatric Clinic, Ryhov County Hospital, Jönköping, Sweden4 aut
7001 a Eneström, Gunillau Pediatric Clinic, Västervik Hospital, Västervik, Sweden4 aut
7001 a Nordwall, Mariau Pediatric Clinic, Vrinnevi Hospital, Norrköping, Sweden4 aut0 (Swepub:liu)marno88
7001 a Ekerfelt, Christinau Linköpings universitet,Klinisk immunologi,Hälsouniversitetet4 aut0 (Swepub:liu)chrek55
7001 a Croner, Stefanu Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)stecr16
7102 a Linköpings universitetb Klinisk immunologi4 org
7730 t International Immunologyd : Oxford University Press (OUP)g 17:10, s. 1283-1291q 17:10<1283-1291x 0953-8178x 1460-2377
8564 u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11520y Link to Ph.D. thesis
8564 u https://academic.oup.com/intimm/article-pdf/17/10/1283/2466558/dxh304.pdf
8564 u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=16176932&dopt=Citation
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-13161
8564 8u https://doi.org/10.1093/intimm/dxh304
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-12938

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