WFRF:(Jensen D. H.)
Sökning: WFRF:(Jensen D. H.) > (1995-1999) > Peptide nucleic aci...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02870naa a2200373 4500 | |
| 001 | oai:research.chalmers.se:2fcbfaeb-fb16-43d1-a833-8260cc46be26 | |
| 003 | SwePub | |
| 008 | 171007s1999 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://research.chalmers.se/publication/1369562 URI |
| 024 | 7 | a https://doi.org/10.1039/A902091H2 DOI |
| 040 | a (SwePub)cth | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Haaima, G.4 aut |
| 245 | 1 0 | a Peptide nucleic acids (PNA) derived from N-(N-methylaminoethyl)glycine. Synthesis, hybridization and structural properties |
| 264 | 1 | c 1999 |
| 520 | a Backbone N-methylated peptide nucleic acids (PNAs) containing the four nucleobases adenine, cytosine, guanine and thymine were synthesized via solid phase peptide oligomerization. The oligomers bind to their complementary target with a thermal stability that is 1.5-4.5 degrees C lower per "N-methyl nucleobase unit" [dependent on the number and position(s) of the N-methyl] than that of unmodified PNA. However, even fully N-methyl modified PNAs bind as efficiently to DNA or RNA targets as DNA itself. Furthermore, the hybridization efficiency per N-methyl unit in a PNA decreased with increasing N-methyl content, and the effect was more pronounced when the N-methyl backbone units are present in the Hoogsteen versus the Watson-Crick strand in (PNA)(2)-DNA triplexes. Interestingly, CD spectral analyses indicate that 30% (3 out of ten) substitution with N-methyl nucleobases did not alter the structure of PNA-DNA (or RNA) duplexes or (PNA)(2)-DNA triplexes, and likewise CD spectroscopy and X-ray crystallography showed no major structural differences between N-methylated (30%) and unmodified PNA-PNA duplexes. However, PNA-DNA duplexes as well as triplexes adopted a different conformation when formed with all-Ai-methyl PNAs. | |
| 650 | 7 | a NATURVETENSKAPx Kemix Fysikalisk kemi0 (SwePub)104022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Chemical Sciencesx Physical Chemistry0 (SwePub)104022 hsv//eng |
| 700 | 1 | a Rasmussen, H.4 aut |
| 700 | 1 | a Schmidt, G.4 aut |
| 700 | 1 | a Jensen, D.K.4 aut |
| 700 | 1 | a Sandholm Kastrup, J.4 aut |
| 700 | 1 | a Wittung Stafshede, Pernilla,d 1968u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)perwit |
| 700 | 1 | a Nordén, Bengt,d 1945u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)norden |
| 700 | 1 | a Buchardt, O.4 aut |
| 700 | 1 | a Nielsen, P.E.4 aut |
| 710 | 2 | a Chalmers tekniska högskola4 org |
| 773 | 0 | t New Journal of Chemistryg 23:8, s. 833-840q 23:8<833-840x 1369-9261x 1144-0546 |
| 856 | 4 | u http://dx.doi.org/10.1039/A902091Hy FULLTEXT |
| 856 | 4 8 | u https://research.chalmers.se/publication/136956 |
| 856 | 4 8 | u https://doi.org/10.1039/A902091H |
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