Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer

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Fältnamn	Indikatorer	Metadata
000		04109naa a2200421 4500
001		oai:DiVA.org:umu-81827
003		SwePub
008		131022s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-818272 URI
024	7	a https://doi.org/10.1016/j.bbalip.2012.12.0052 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Fowler, Christopher J.u Umeå universitet,Farmakologi4 aut0 (Swepub:umu)chfo0001
245	1 0	a Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer
264	1	b Elsevier BV,c 2013
338		a print2 rdacarrier
520		a Fatty acid amide hydrolase (FAAH) is responsible for the hydrolysis of the endogenous cannabinoid (CB) receptor ligand anandamide. Here we have investigated whether the expression levels of FAAH and CB1 receptors influence the prognostic value of markers of angiogenesis in prostate cancer. Data from a cohort of 419 patients who were diagnosed with prostate cancer at transurethral resection for lower urinary tract symptoms, of whom approximately 2/3 had been followed by expectancy, were used. Scores for the angiogenesis markers endoglin and von Willebrand factor (vWf), the endocannabinoid markers fatty acid amide hydrolase (FAAH) and cannabinoid CB1 receptors and the cell proliferation marker Ki-67 were available in the database. For the cases followed by expectancy, the prognostic value of endoglin was dependent upon the tumour epithelial FAAH immunoreactivity (FAAH-IR) and CB1IR scores, and the non-malignant epithelial FAAH-IR scores, but not the non-malignant CB1IR scores or the tumour blood vessel FAAH-IR scores. This dependency upon the tumour epithelial FAAH-IR or CB1IR scores was less apparent for vWf, and was not seen for Ki-67. Using an endoglin cut-off value of 10 positively stained vessels per core and a median split of tumour FAAH-IR, four groups could be generated, with 15 year of disease-specific survival (%) of 68 +/- 7 (low endoglin, low FAAH), 45 +/- 11 (high endoglin, low FAAH), 77 +/- 6 (low endoglin, high FAAH) and 21 +/- 10 (high endoglin, high FAAH). Thus, the cases with high endoglin and high FAAH scores have the poorest rate of disease-specific survival. At diagnosis, the number of cases with tumour stages 1a-1b relative to stages 2-4 was sensitive to the endoglin score in a manner dependent upon the tumour FAAH-IR. It is concluded that the prognostic value of endoglin as a marker of neovascularisation in prostate cancer can be influenced by the expression level of markers of the endocannabinoid system. This article is part of a Special Issue entitled Lipid Metabolism in Cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
653		a Cannabinoid CB1 receptor
653		a Fatty acid amide hydrolase
653		a Angiogenesis
653		a Endoglin
653		a von Willebrand factor
653		a Prostate cancer
700	1	a Josefsson, Andreasu Umeå universitet,Patologi4 aut0 (Swepub:umu)aasjon01
700	1	a Thors, Linau Umeå universitet,Farmakologi4 aut
700	1	a Chung, Sui Chuu Umeå universitet,Farmakologi4 aut
700	1	a Hammarsten, Peteru Umeå universitet,Patologi4 aut0 (Swepub:umu)perhan98
700	1	a Wikström, Pernillau Umeå universitet,Patologi4 aut0 (Swepub:umu)pewi0001
700	1	a Bergh, Andersu Umeå universitet,Patologi4 aut0 (Swepub:umu)anbe0010
710	2	a Umeå universitetb Farmakologi4 org
773	0	t Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipidsd : Elsevier BVg 1831:10, s. 1579-1587q 1831:10<1579-1587x 1388-1981x 1879-2618
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-81827
856	4 8	u https://doi.org/10.1016/j.bbalip.2012.12.005

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