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Post-load glucose s...
Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study
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- Obura, Morgan (författare)
- Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.
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- Beulens, Joline W.J. (författare)
- Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,University Medical Center Utrecht,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
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- Slieker, Roderick (författare)
- Leiden University Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Koopman, Anitra D.M. (författare)
- Academic Medical Center of University of Amsterdam (AMC)
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- Hoekstra, Trynke (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Nijpels, Giel (författare)
- Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam
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- Elders, Petra (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Koivula, Robert W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford
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- Kurbasic, Azra (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Laakso, Markku (författare)
- University of Eastern Finland,Kuopio University Hospital
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- Hansen, Tue H. (författare)
- University of Copenhagen,Slagelse Hospital
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- Ridderstråle, Martin (författare)
- University of Copenhagen
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- Hansen, Torben (författare)
- University of Copenhagen,University of Southern Denmark
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- Pavo, Imre (författare)
- Eli Lilly Regional Operations G.m.b.H.
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- Forgie, Ian (författare)
- University of Dundee,Ninewells Hospital and Medical School
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- Jablonka, Bernd (författare)
- Sanofi-Aventis Deutschland GmbH
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- Ruetten, Hartmut (författare)
- Sanofi-Aventis Deutschland GmbH
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- Mari, Andrea (författare)
- CNR Institute of Biomedical Engineering
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- McCarthy, Mark I. (författare)
- University of Oxford,Wellcome Trust Centre for Human Genetics
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- Walker, Mark (författare)
- University of Newcastle upon Tyne
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- Heggie, Alison (författare)
- University of Newcastle upon Tyne
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- McDonald, Timothy J. (författare)
- University of Exeter,Royal Devon and Exeter NHS Foundation Trust
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- Perry, Mandy H. (författare)
- Royal Devon and Exeter NHS Foundation Trust
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- De Masi, Federico (författare)
- Technical University of Denmark
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- Brunak, Søren (författare)
- University of Copenhagen,Technical University of Denmark
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- Mahajan, Anubha (författare)
- Wellcome Trust Centre for Human Genetics
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- Giordano, Giuseppe N. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
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- Kokkola, Tarja (författare)
- Kuopio University Hospital,University of Eastern Finland
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- Dermitzakis, Emmanouil (författare)
- University of Geneva,Swiss Institute for Bioinformatics (SIB)
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- Viñuela, Ana (författare)
- Swiss Institute for Bioinformatics (SIB),University of Geneva
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- Pedersen, Oluf (författare)
- University of Copenhagen
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- Schwenk, Jochen M. (författare)
- KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Adamski, Jurek (författare)
- Technical University of Munich,National University of Singapore,Helmholtz Zentrum München,University of Oxford
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- Teare, Harriet J.A. (författare)
- University of Oxford
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- Pearson, Ewan R. (författare)
- University of Dundee
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University,University of Oxford
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- 't Hart, Leen M. (författare)
- Leiden University Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam,Academic Medical Center of University of Amsterdam (AMC)
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- Rutters, Femke (författare)
- Academic Medical Center of University of Amsterdam (AMC),Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Univ Med Ctr, Locat VU Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Epidemiol & Data Sci, Amsterdam, Netherlands.
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(creator_code:org_t)
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- 2020-11-30
- 2020
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- AIM: Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. METHODS: The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. RESULTS: At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1-3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18-1.92) for subgroup 2 and 1.88 (-0.08-3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. CONCLUSIONS: Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Obura, Morgan
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Beulens, Joline ...
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Slieker, Roderic ...
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Koopman, Anitra ...
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Hoekstra, Trynke
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Nijpels, Giel
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visa fler...
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Elders, Petra
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Koivula, Robert ...
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Kurbasic, Azra
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Laakso, Markku
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Hansen, Tue H.
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Ridderstråle, Ma ...
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Hansen, Torben
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Pavo, Imre
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Forgie, Ian
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Jablonka, Bernd
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Ruetten, Hartmut
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Mari, Andrea
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McCarthy, Mark I ...
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Walker, Mark
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Heggie, Alison
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McDonald, Timoth ...
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Perry, Mandy H.
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De Masi, Federic ...
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Brunak, Søren
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Mahajan, Anubha
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Giordano, Giusep ...
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Kokkola, Tarja
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Dermitzakis, Emm ...
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Viñuela, Ana
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Pedersen, Oluf
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Schwenk, Jochen ...
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Adamski, Jurek
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Teare, Harriet J ...
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Pearson, Ewan R.
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Franks, Paul W.
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't Hart, Leen M.
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Rutters, Femke
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MEDICIN OCH HÄLS ...
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och Endokrinologi oc ...
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