WFRF:(Kaptoge S.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08070naa a2201261 4500 | |
| 001 | oai:gup.ub.gu.se/193508 | |
| 003 | SwePub | |
| 008 | 240528s2014 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:1de5da30-dc43-48a6-95ac-8d9cc8b31b55 | |
| 009 | oai:DiVA.org:uu-218542 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1935082 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bone.2013.10.0152 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/43194182 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2185422 URI |
| 040 | a (SwePub)gud (SwePub)lud (SwePub)uu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Oei, L.4 aut |
| 245 | 1 0 | a Genome-wide association study for radiographic vertebral fractures: A potential role for the 16q24 BMD locus |
| 264 | 1 | b Elsevier BV,c 2014 |
| 520 | a Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p<5 x 10(-8). In the discovery, a SNP (rs11645938) on chromosome 16q24 was associated with the risk for vertebral fractures at p = 4.6 x 10(-8). However, the association was not significant across 5720 cases and 21,791 controls from 14 studies. Fixed-effects meta-analysis summary estimate was 1.06 (95% Cl: 0.98-1.14; p = 0.17), displaying high degree of heterogeneity (I-2= 57%; Q(het)p = 0.0006). Under Han-Eskin alternative random effects model the summary effect was significant (p = 0.0005). The SNP maps to a region previously found associated with lumbar spine bone mineral density (LS-BMD) in two large meta-analyses from the GEFOS consortium. A false positive association in the GWAS discovery cannot be excluded, yet, the low-powered setting of the discovery and replication settings (appropriate to identify risk effect size >1.25) may still be consistent with an effect size <1.10, more of the type expected in complex traits. Larger effort in studies with standardized phenotype definitions is needed to confirm or reject the involvement of this locus on the risk for vertebral fractures. (C) 2013 Elsevier Inc. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 653 | a Genome-wide association study | |
| 653 | a Vertebral fracture risk | |
| 653 | a Genetics of osteoporosis | |
| 653 | a GEFOS consortium | |
| 653 | a XC2 | |
| 653 | a BONE-MINERAL DENSITY | |
| 653 | a QUALITY-OF-LIFE | |
| 653 | a EUROPEAN PROSPECTIVE | |
| 653 | a OSTEOPOROSIS | |
| 653 | a POSTMENOPAUSAL WOMEN | |
| 653 | a GEELONG-OSTEOPOROSIS | |
| 653 | a TURNOVER | |
| 653 | a MARKERS | |
| 653 | a CAMARGO COHORT | |
| 653 | a ELDERLY-WOMEN | |
| 653 | a Genetics of | |
| 653 | a osteoporosis | |
| 653 | a FOXC2 | |
| 653 | a Genome-wide association study | |
| 700 | 1 | a Estrada, K.4 aut |
| 700 | 1 | a Duncan, E. L.4 aut |
| 700 | 1 | a Christiansen, C.4 aut |
| 700 | 1 | a Liu, C. T.4 aut |
| 700 | 1 | a Langdahl, B. L.4 aut |
| 700 | 1 | a Obermayer-Pietsch, B.4 aut |
| 700 | 1 | a Riancho, J. A.4 aut |
| 700 | 1 | a Prince, R. L.4 aut |
| 700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xmelda |
| 700 | 1 | a McCloskey, E.4 aut |
| 700 | 1 | a Hsu, Y. H.4 aut |
| 700 | 1 | a Evangelou, E.4 aut |
| 700 | 1 | a Ntzani, E.4 aut |
| 700 | 1 | a Evans, D. M.4 aut |
| 700 | 1 | a Alonso, N.4 aut |
| 700 | 1 | a Husted, L. B.4 aut |
| 700 | 1 | a Valero, C.4 aut |
| 700 | 1 | a Hernandez, J. L.4 aut |
| 700 | 1 | a Lewis, J. R.4 aut |
| 700 | 1 | a Kaptoge, S. K.4 aut |
| 700 | 1 | a Zhu, K.4 aut |
| 700 | 1 | a Cupples, L. A.4 aut |
| 700 | 1 | a Medina-Gomez, C.4 aut |
| 700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
| 700 | 1 | a Kim, G. S.4 aut |
| 700 | 1 | a Lee, S. H.4 aut |
| 700 | 1 | a Castano-Betancourt, M. C.4 aut |
| 700 | 1 | a Oei, E. H. G.4 aut |
| 700 | 1 | a Martinez, J.4 aut |
| 700 | 1 | a Daroszewska, A.4 aut |
| 700 | 1 | a van der Klift, M.4 aut |
| 700 | 1 | a Mellström, Dan,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Centre for Bone and Arthritis Research,Institute of Medicine, School of Public Health and Community Medicine4 aut0 (Swepub:gu)xmelda |
| 700 | 1 | a Herrera, L.4 aut |
| 700 | 1 | a Karlsson, Magnusu Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)orto-mka |
| 700 | 1 | a Hofman, A.4 aut |
| 700 | 1 | a Ljunggren, Östenu Uppsala universitet,Endokrinologi och mineralmetabolism4 aut0 (Swepub:uu)osteljun |
| 700 | 1 | a Pols, H. A. P.4 aut |
| 700 | 1 | a Stolk, L.4 aut |
| 700 | 1 | a van Meurs, J. B. J.4 aut |
| 700 | 1 | a Ioannidis, J. P. A.4 aut |
| 700 | 1 | a Zillikens, M. C.4 aut |
| 700 | 1 | a Lips, P.4 aut |
| 700 | 1 | a Karasik, D.4 aut |
| 700 | 1 | a Uitterlinden, A. G.4 aut |
| 700 | 1 | a Styrkarsdottir, U.4 aut |
| 700 | 1 | a Brown, M. A.4 aut |
| 700 | 1 | a Koh, Jung-Minu Gothenburg University,Göteborgs universitet,Institutionen för medicin,Centre for Bone and Arthritis Research,Institute of Medicine4 aut |
| 700 | 1 | a Richards, J. B.4 aut |
| 700 | 1 | a Reeve, J.4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Ralston, S. H.4 aut |
| 700 | 1 | a Kiel, D. P.4 aut |
| 700 | 1 | a Rivadeneira, F.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa4 org |
| 773 | 0 | t Boned : Elsevier BVg 59, s. 20-27q 59<20-27x 8756-3282x 1873-2763 |
| 856 | 4 | u https://europepmc.org/articles/pmc4102322?pdf=render |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/24513584?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1016/j.bone.2013.10.015y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/193508 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bone.2013.10.015 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4319418 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-218542 |
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- Estrada, K.
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- Langdahl, B. L.
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- Riancho, J. A.
- Prince, R. L.
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- McCloskey, E.
- Hsu, Y. H.
- Evangelou, E.
- Ntzani, E.
- Evans, D. M.
- Alonso, N.
- Husted, L. B.
- Valero, C.
- Hernandez, J. L.
- Lewis, J. R.
- Kaptoge, S. K.
- Zhu, K.
- Cupples, L. A.
- Medina-Gomez, C.
- Vandenput, Liesb ...
- Kim, G. S.
- Lee, S. H.
- Castano-Betancou ...
- Oei, E. H. G.
- Martinez, J.
- Daroszewska, A.
- van der Klift, M ...
- Herrera, L.
- Karlsson, Magnus
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- Ljunggren, Östen
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- Lips, P.
- Karasik, D.
- Uitterlinden, A. ...
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- Brown, M. A.
- Koh, Jung-Min
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