Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe

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Fältnamn	Indikatorer	Metadata
000		03229naa a2200409 4500
001		oai:prod.swepub.kib.ki.se:141733579
003		SwePub
008		240701s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1417335792 URI
024	7	a https://doi.org/10.1136/heartjnl-2018-3142562 DOI
040		a (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Frohlich, H4 aut
245	1 0	a Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe
264		c 2019-02-21
264	1	b BMJ,c 2019
520		a To describe the epidemiology, long-term outcomes and temporal trends in mortality in ambulatory patients with chronic heart failure (HF) with reduced (HFrEF), mid-range (HFmrEF) or preserved ejection fraction (HFpEF) from three European countries.MethodsWe identified 10 312 patients from the Norwegian HF Registry and the HF registries of the universities of Heidelberg, Germany, and Hull, UK. Patients were classified according to baseline left ventricular ejection fraction (LVEF) and time of enrolment (period 1: 1995–2005 vs period 2: 2006–2015). Predictors of mortality were analysed by use of univariable and multivariable Cox regression analyses.ResultsAmong 10 312 patients with stable HF, 7080 (68.7%), 2086 (20.2%) and 1146 (11.1%) were classified as having HFrEF, HFmrEF or HFpEF, respectively. A total of 4617 (44.8%) patients were included in period 1, and 5695 (55.2%) patients were included in period 2. Baseline characteristics significantly differed with respect to type of HF and time of enrolment. During a median follow-up of 66 (33–105) months, 5297 patients (51.4%) died. In multivariable analyses, survival was independent of LVEF category (p>0.05), while mortality was lower in period 2 as compared with period 1 (HR 0.81, 95% CI 0.72 to 0.91, p<0.001). Significant predictors of all-cause mortality regardless of HF category were increasing age, New York Heart Association functional class, N-terminal pro-brain natriuretic peptide and use of loop diuretics.ConclusionAmbulatory patients with HF stratified by LVEF represent different phenotypes. However, after adjusting for a wide range of covariates, long-term survival is independent of LVEF category. Outcome significantly improved during the last two decades irrespective from type of HF.
700	1	a Rosenfeld, N4 aut
700	1	a Tager, T4 aut
700	1	a Goode, K4 aut
700	1	a Kazmi, S4 aut
700	1	a Hole, T4 aut
700	1	a Katus, HA4 aut
700	1	a Atar, D4 aut
700	1	a Cleland, JGF4 aut
700	1	a Agewall, Su Karolinska Institutet4 aut
700	1	a Clark, AL4 aut
700	1	a Frankenstein, L4 aut
700	1	a Grundtvig, M4 aut
710	2	a Karolinska Institutet4 org
773	0	t Heart (British Cardiac Society)d : BMJg 105:16, s. 1252-1259q 105:16<1252-1259x 1468-201Xx 1355-6037
856	4	u http://eprints.gla.ac.uk/180118/7/180118.pdf
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141733579
856	4 8	u https://doi.org/10.1136/heartjnl-2018-314256

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Av författaren/redakt...: Frohlich, H; Rosenfeld, N; Tager, T; Goode, K; Kazmi, S; Hole, T; visa fler...; Katus, HA; Atar, D; Cleland, JGF; Agewall, S; Clark, AL; Frankenstein, L; Grundtvig, M; visa färre...

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