Sökning: WFRF:(Kim Yun Jung)
> (2010-2014) >
A simple pharmacoki...
A simple pharmacokinetic model of alendronate developed using plasma concentration and urine excretion data from healthy men
-
- Chae, Jung-woo (författare)
- Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
-
- Seo, Jeong-won (författare)
- NiFDS, New Drug Res Team, Chungcheongbuk Do, South Korea.
-
- Mahat, Bimit (författare)
- Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
-
visa fler...
-
- Yun, Hwi-yeol (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Uppsala Univ, Uppsala Pharmacometr, Uppsala, Sweden.
-
- Baek, In-hwan (författare)
- Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
-
- Lee, Byung-yo (författare)
- Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
-
- Kim, Dong-hyun (författare)
- Hanmi Res Ctr, Hwaseong Si, South Korea.
-
- Kwon, Kwang-il (författare)
- Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
-
visa färre...
-
Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea NiFDS, New Drug Res Team, Chungcheongbuk Do, South Korea. (creator_code:org_t)
- 2013-07-25
- 2014
- Engelska.
-
Ingår i: Drug Development and Industrial Pharmacy. - : Informa UK Limited. - 0363-9045 .- 1520-5762. ; 40:10, s. 1325-1329
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- The study of pharmacokinetics of alendronate has been hampered by difficulties in accurately and reproducibly determining their concentrations in serum and urine. Thus, pharmacokinetic characteristics of alendronate have been described in many reports based on urinary excretion data; and plasma pharmacokinetics and the simultaneous pharmacokinetic models of alendronate in plasma and urine are not available. The aims of this study were to measure alendronate concentration in plasma and excretion in urine concurrently and to develop compartmental pharmacokinetic model using urine data. In open-label, single-dose pharmacokinetic study, 10 healthy male volunteers received oral dose of alendronate (70mg tablet). Blood and urine alendronate concentrations were determined using validated high-performance liquid chromatography method. Non-compartmental analysis was performed using WinNonlin program (Pharsight Inc., Apex, NC). A one-compartment pharmacokinetic model was applied to describe pharmacokinetics of alendronate. A peak plasma alendronate concentration of 33.10 +/- 14.32 ng/mL was attained after 1.00 +/- 0.16 h. The cumulative amount of alendronate excreted in urine and peak excretion rate were 731.28 +/- 654.57 mu g and 314.68 +/- 395.43 mg/h, respectively. The model, which included first-order absorption rate for oral dosing, showed good fit to alendronate data obtained from plasma and urine. The absorption rate constant was 2.68 +/- 0.95 h(-1). The elimination rate constants K-urine and Knon-ur were 0.005 +/- 0.004 h(-1) and 0.42 +/- 0.08 h(-1), respectively. The pharmacokinetics of alendronate in plasma and urine of healthy men can be predicted using one-compartment model, and thus the behavior of drug in plasma can be estimated from urinary excretion data.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Alendronate
- modeling
- men
- pharmacokinetics
- plasma
- urine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas