Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.

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Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation.

Vasara, Anna I (author): Department of Orthopaedics, Helsinki University Hospital, Peijas Hospital, Vantaa, Finland

Hyttinen, M M (author): Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland

Lammi, Mikko, 1961- (author): Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group

Pulliainen, O (author): Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland

Jurvelin, Jukka S (author): jukka.jurvelin@uef.fi Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland; Department of Applied Physics, University of Kuopio, Kuopio, Finland

Peterson, Lars, 1936 (author): Department of Orthopedics, Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden

Lindahl, Anders, 1954 (author): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Göteborg University, Sahlgrenska University Hospital, Gothenburg, Sweden

Helminen, H J (author): Institute of Biomedicine, Department of Anatomy, University of Kuopio, Kuopio, Finland

Kiviranta, Ilkka (author): Department of Surgery, Division of Orthopaedics and Traumatology, Jyväskylä Central Hospital, Jyväskylä, Finland

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Elsevier BV, 2006
2006
English.
In: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. - : Elsevier BV. - 1063-4584 .- 1522-9653. ; 14:10, s. 1066-74

Related links:: http://www.oarsijour...; show more...; http://Department of...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE: The purpose of this study was to find out how deep chondral lesions heal in growing animals spontaneously and after autologous chondrocyte transplantation. METHODS: A 6mm deep chondral lesion was created in the knee joints of 57 immature pigs and repaired with autologous chondrocyte transplantation covered with periosteum or muscle fascia, with periosteum only, or left untreated. After 3 and 12 months, the repair tissue was evaluated with International Cartilage Repair Society (ICRS) macroscopic grading, modified O'Driscoll histological scoring, and staining for collagen type II and hyaluronan, and with toluidine blue and safranin-O staining for glycosaminoglycans. The repair tissue structure was also examined with quantitative polarized light microscopy and indentation analysis of the cartilage stiffness. RESULTS: The ICRS grading indicated nearly normal repair tissue in 65% (10/17) after the autologous chondrocyte transplantation and 86% (7/8) after no repair at 3 months. At 1 year, the repair tissue was nearly normal in all cases in the spontaneous repair group and in 38% (3/8) in the chondrocyte transplantation group. In most cases, the cartilage repair tissue stained intensely for glycosaminoglycans and collagen type II indicating repair tissue with true constituents of articular cartilage. There was a statistical difference in the total histological scores at 3 months (P=0.028) with the best repair in the spontaneous repair group. A marked subchondral bone reaction, staining with toluidine blue and collagen type II, was seen in 65% of all animals. CONCLUSIONS: The spontaneous repair ability of full thickness cartilage defects of immature pigs is significant and periosteum or autologous chondrocytes do not bring any additional benefits to the repair.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)

Keyword

Animals
Cartilage
Articular
injuries
surgery
Chondrocytes
transplantation
Collagen Type II
chemistry
Glycosaminoglycans
chemistry
Hindlimb
Hyaluronic Acid
chemistry
Knee Joint
surgery
Periosteum
transplantation
Swine
Transplantation
Autologous
Wound Healing
Articular cartilage
cell research
ortopedi

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Vasara, Anna I; Hyttinen, M M; Lammi, Mikko, 19 ...; Pulliainen, O; Jurvelin, Jukka ...; Peterson, Lars, ...; show more...; Lindahl, Anders, ...; Helminen, H J; Kiviranta, Ilkka; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

Articles in the publication: Osteoarthritis a ...

By the university: University of Gothenburg; Umeå University

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