SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Kleinjans Jos C. S.)
 

Sökning: WFRF:(Kleinjans Jos C. S.) > Identification of S...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004154naa a2200529 4500
001oai:DiVA.org:umu-155826
003SwePub
008190128s2019 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1558262 URI
0247 a https://doi.org/10.1038/s41598-018-37449-y2 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Espín-Pérez, Almudena4 aut
2451 0a Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)
264 c 2019-01-24
264 1b Nature Publishing Group,c 2019
338 a electronic2 rdacarrier
520 a PCBs are classified as xenoestrogens and carcinogens and their health risks may be sex-specific. To identify potential sex-specific responses to PCB-exposure we established gene expression profiles in a population study subdivided into females and males. Gene expression profiles were determined in a study population consisting of 512 subjects from the EnviroGenomarkers project, 217 subjects who developed lymphoma and 295 controls were selected in later life. We ran linear mixed models in order to find associations between gene expression and exposure to PCBs, while correcting for confounders, in particular distribution of white blood cells (WBC), as well as random effects. The analysis was subdivided according to sex and development of lymphoma in later life. The changes in gene expression as a result of exposure to the six studied PCB congeners were sex- and WBC type specific. The relatively large number of genes that are significantly associated with PCB-exposure in the female subpopulation already indicates different biological response mechanisms to PCBs between the two sexes. The interaction analysis between different PCBs and WBCs provides only a small overlap between sexes. In males, cancer-related pathways and in females immune system-related pathways are identified in association with PCBs and WBCs. Future lymphoma cases and controls for both sexes show different responses to the interaction of PCBs with WBCs, suggesting a role of the immune system in PCB-related cancer development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a epidemiologi
653 a Epidemiology
7001 a Hebels, Dennie G. A. J.4 aut
7001 a Kiviranta, Hannu4 aut
7001 a Rantakokko, Panu4 aut
7001 a Georgiadis, Panagiotis4 aut
7001 a Botsivali, Maria4 aut
7001 a Bergdahl, Ingvaru Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001
7001 a Palli, Domenico4 aut
7001 a Späth, Florentin,d 1980-u Umeå universitet,Enheten för biobanksforskning,Yrkes- och miljömedicin4 aut0 (Swepub:umu)flsp0001
7001 a Johansson, Andersu Umeå universitet,Enheten för biobanksforskning,Yrkes- och miljömedicin,Aa-gruppen4 aut0 (Swepub:umu)anjo0002
7001 a Chadeau-Hyam, Marc4 aut
7001 a Kyrtopoulos, Soterios A4 aut
7001 a Kleinjans, Jos C. S.4 aut
7001 a de Kok, Theo M. C. M.4 aut
7102 a Umeå universitetb Yrkes- och miljömedicin4 org
7730 t Scientific Reportsd : Nature Publishing Groupg 9q 9x 2045-2322
8564 u https://doi.org/10.1038/s41598-018-37449-yy Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1283312/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-018-37449-y.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-155826
8564 8u https://doi.org/10.1038/s41598-018-37449-y

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy