Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials

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MARC

Fältnamn	Indikatorer	Metadata
000		05164naa a2200637 4500
001		oai:DiVA.org:liu-171952
003		SwePub
008		201216s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:145189963
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1719522 URI
024	7	a https://doi.org/10.7150/thno.483422 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1451899632 URI
040		a (SwePub)liud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Han, Young Joou Sungkyunkwan Univ, South Korea4 aut
245	1 0	a Treatment of severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19): a systematic review of in vitro, in vivo, and clinical trials
264	1	b IVYSPRING INT PUBL,c 2021
338		a electronic2 rdacarrier
520		a Rationale: Coronavirus disease 2019 (COVID-19) has spread worldwide and poses a threat to humanity. However, no specific therapy has been established for this disease yet. We conducted a systematic review to highlight therapeutic agents that might be effective in treating COVID-19. Methods: We searched Medline, Medrxiv.org, and reference lists of relevant publications to identify articles of in vitro, in vivo, and clinical studies on treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and COVID-19 published in English until the last update on October 11, 2020. Results: We included 36 studies on SARS, 30 studies on MERS, and 10 meta-analyses on SARS and MERS in this study. Through 12,200 title and 830 full-text screenings for COVID-19, eight in vitro studies, 46 randomized controlled trials (RCTs) on 6,886 patients, and 29 meta-analyses were obtained and investigated. There was no therapeutic agent that consistently resulted in positive outcomes across SARS, MERS, and COVID-19. Remdesivir showed a therapeutic effect for COVID-19 in two RCTs involving the largest number of total participants (n = 1,461). Other therapies that showed an effect in at least two RCTs for COVID-19 were sofosbuvir/daclatasvir (n = 114), colchicine (n = 140), IFN-beta 1b (n = 193), and convalescent plasma therapy (n = 126). Conclusions: This review provides information to help establish treatment and research directions for COVID-19 based on currently available evidence. Further RCTs are required.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a COVID-19; therapeutic agent; SARS; MERS; mortality; coronavirus
700	1	a Lee, Keum Hwau Yonsei Univ, South Korea4 aut
700	1	a Yoon, Sojungu Yonsei Univ, South Korea4 aut
700	1	a Nam, Seoung Wanu Yonsei Univ, South Korea4 aut
700	1	a Ryu, Seohyunu Yonsei Univ, South Korea4 aut
700	1	a Seong, Dawonu Yonsei Univ, South Korea4 aut
700	1	a Kim, Jae Seoku Yonsei Univ, South Korea4 aut
700	1	a Lee, Jun Youngu Yonsei Univ, South Korea4 aut
700	1	a Yang, Jae Wonu Yonsei Univ, South Korea4 aut
700	1	a Lee, Jinheeu Yonsei Univ, South Korea4 aut
700	1	a Koyanagi, Aiu Univ Barcelona, Spain; ICREA, Spain4 aut
700	1	a Hong, Sung Hwiu Harvard TH Chan Sch Publ Hlth, MA USA4 aut
700	1	a Dragioti, Elenau Linköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum4 aut0 (Swepub:liu)eledr71
700	1	a Radua, Joaquimu Karolinska Institutet4 aut
700	1	a Smith, Leeu Anglia Ruskin Univ, England4 aut
700	1	a Oh, Hansu Univ Southern Calif, CA 90089 USA4 aut
700	1	a Abou Ghayda, Ramyu Harvard TH Chan Sch Publ Hlth, MA USA; Brigham & Womens Hosp, MA 02115 USA; Harvard Med Sch, MA 02115 USA4 aut
700	1	a Kronbichler, Andreasu Med Univ Innsbruck, Austria4 aut
700	1	a Effenberger, Mariau Med Univ Innsbruck, Austria4 aut
700	1	a Kresse, Danielau St Johann Cty Hosp, Austria4 aut
700	1	a Denicolo, Sarau Med Univ Innsbruck, Austria4 aut
700	1	a Kang, Woosunu Univ Illinois, IL USA4 aut
700	1	a Jacob, Louisu Univ Barcelona, Spain; Univ Versailles St Quentin En Yvelines, France4 aut
700	1	a Shin, Hanwulu Yonsei Univ, South Korea4 aut
700	1	a Shin, Jae Ilu Yonsei Univ, South Korea4 aut
710	2	a Sungkyunkwan Univ, South Koreab Yonsei Univ, South Korea4 org
773	0	t Theranosticsd : IVYSPRING INT PUBLg 11:3, s. 1207-1231q 11:3<1207-1231x 1838-7640
856	4	u https://liu.diva-portal.org/smash/get/diva2:1510466/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://europepmc.org/articles/pmc7738873?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-171952
856	4 8	u https://doi.org/10.7150/thno.48342
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:145189963

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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