Sökning: WFRF:(Kubo Michiaki) > (2015-2019) > Genome-wide analysi...
Fältnamn | Indikatorer | Metadata |
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001 | oai:lup.lub.lu.se:faec2925-abee-4bb5-bac4-9623c97f3fce | |
003 | SwePub | |
008 | 190703s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-161588 | |
009 | oai:prod.swepub.kib.ki.se:141242177 | |
024 | 7 | a https://lup.lub.lu.se/record/faec2925-abee-4bb5-bac4-9623c97f3fce2 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-10630-12 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1615882 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412421772 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Shungin, Dmitryu Umeå universitet,Umeå University,Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003 |
245 | 1 0 | a Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data |
264 | c 2019-06-24 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng |
700 | 1 | a Haworth, Simonu University of Bristol4 aut |
700 | 1 | a Divaris, Kimonu University of North Carolina4 aut |
700 | 1 | a Agler, Cary S.u University of North Carolina,Osaka University4 aut |
700 | 1 | a Kamatani, Yoichirou RIKEN Center for Integrative Medical Sciences4 aut |
700 | 1 | a Keun Lee, Myoungu University of Pittsburgh4 aut |
700 | 1 | a Grinde, Kelseyu University of Washington4 aut |
700 | 1 | a Hindy, Georgeu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-ghu |
700 | 1 | a Alaraudanjoki, Viiviu University of Oulu4 aut |
700 | 1 | a Pesonen, Paulau Karolinska Institutet4 aut |
700 | 1 | a Teumer, Alexanderu University Medicine Greifswald4 aut |
700 | 1 | a Holtfreter, Birteu University Medicine Greifswald4 aut |
700 | 1 | a Sakaue, Saoriu Osaka University4 aut |
700 | 1 | a Hirata, Junu Osaka University4 aut |
700 | 1 | a Yu, Yau Huau Brigham and Women's Hospital / Harvard Medical School,Tufts University4 aut |
700 | 1 | a Ridker, Paul M.u Harvard University,Brigham and Women's Hospital / Harvard Medical School4 aut |
700 | 1 | a Giulianini, Francou Brigham and Women's Hospital / Harvard Medical School4 aut |
700 | 1 | a Chasman, Daniel I.u Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut |
700 | 1 | a Magnusson, Patrik K.E.u Karolinska Institute4 aut |
700 | 1 | a Sudo, Takeakiu Tokyo Medical and Dental University4 aut |
700 | 1 | a Okada, Yukinoriu Osaka University4 aut |
700 | 1 | a Völker, Uweu University Medicine Greifswald4 aut |
700 | 1 | a Kocher, Thomasu University Medicine Greifswald4 aut |
700 | 1 | a Anttonen, Vuokkou University of Oulu,Oulu University Hospital4 aut |
700 | 1 | a Laitala, Marja Liisau University of Oulu4 aut |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Sofer, Tamaru Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut |
700 | 1 | a Shaffer, John R.u University of Pittsburgh4 aut |
700 | 1 | a Vieira, Alexandreu University of Pittsburgh4 aut |
700 | 1 | a Marazita, Mary L.u University of Pittsburgh4 aut |
700 | 1 | a Kubo, Michiakiu RIKEN Center for Integrative Medical Sciences4 aut |
700 | 1 | a Furuichi, Yasushiu Hokkaido University4 aut |
700 | 1 | a North, Kari E.u University of North Carolina4 aut |
700 | 1 | a Offenbacher, Steveu University of North Carolina4 aut |
700 | 1 | a Ingelsson, Eriku Stanford University4 aut |
700 | 1 | a Franks, Paul W.u Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö SE-214 28, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Avdelningen för medicin4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Timpson, Nicholas J.u University of Bristol4 aut |
700 | 1 | a Johansson, Ingegerdu Umeå universitet,Umeå University,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003 |
710 | 2 | a Umeå Universityb Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723 |
856 | 4 | u http://dx.doi.org/10.1038/s41467-019-10630-1x freey FULLTEXT |
856 | 4 | u https://www.nature.com/articles/s41467-019-10630-1.pdf |
856 | 4 | u https://doi.org/10.1038/s41467-019-10630-1y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1338348/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://lup.lub.lu.se/record/faec2925-abee-4bb5-bac4-9623c97f3fce |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-10630-1 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161588 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141242177 |
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