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Sökning: WFRF:(Kubo Michiaki) > (2015-2019) > Genome-wide analysi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006822naa a2200865 4500
001oai:lup.lub.lu.se:faec2925-abee-4bb5-bac4-9623c97f3fce
003SwePub
008190703s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-161588
009oai:prod.swepub.kib.ki.se:141242177
0247 a https://lup.lub.lu.se/record/faec2925-abee-4bb5-bac4-9623c97f3fce2 URI
0247 a https://doi.org/10.1038/s41467-019-10630-12 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1615882 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412421772 URI
040 a (SwePub)lud (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Shungin, Dmitryu Umeå universitet,Umeå University,Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003
2451 0a Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data
264 c 2019-06-24
264 1b Springer Science and Business Media LLC,c 2019
520 a Dental caries and periodontitis account for a vast burden of morbidity and healthcare spending, yet their genetic basis remains largely uncharacterized. Here, we identify self-reported dental disease proxies which have similar underlying genetic contributions to clinical disease measures and then combine these in a genome-wide association study meta-analysis, identifying 47 novel and conditionally-independent risk loci for dental caries. We show that the heritability of dental caries is enriched for conserved genomic regions and partially overlapping with a range of complex traits including smoking, education, personality traits and metabolic measures. Using cardio-metabolic traits as an example in Mendelian randomization analysis, we estimate causal relationships and provide evidence suggesting that the processes contributing to dental caries may have undesirable downstream effects on health.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng
7001 a Haworth, Simonu University of Bristol4 aut
7001 a Divaris, Kimonu University of North Carolina4 aut
7001 a Agler, Cary S.u University of North Carolina,Osaka University4 aut
7001 a Kamatani, Yoichirou RIKEN Center for Integrative Medical Sciences4 aut
7001 a Keun Lee, Myoungu University of Pittsburgh4 aut
7001 a Grinde, Kelseyu University of Washington4 aut
7001 a Hindy, Georgeu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-ghu
7001 a Alaraudanjoki, Viiviu University of Oulu4 aut
7001 a Pesonen, Paulau Karolinska Institutet4 aut
7001 a Teumer, Alexanderu University Medicine Greifswald4 aut
7001 a Holtfreter, Birteu University Medicine Greifswald4 aut
7001 a Sakaue, Saoriu Osaka University4 aut
7001 a Hirata, Junu Osaka University4 aut
7001 a Yu, Yau Huau Brigham and Women's Hospital / Harvard Medical School,Tufts University4 aut
7001 a Ridker, Paul M.u Harvard University,Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Giulianini, Francou Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Chasman, Daniel I.u Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut
7001 a Magnusson, Patrik K.E.u Karolinska Institute4 aut
7001 a Sudo, Takeakiu Tokyo Medical and Dental University4 aut
7001 a Okada, Yukinoriu Osaka University4 aut
7001 a Völker, Uweu University Medicine Greifswald4 aut
7001 a Kocher, Thomasu University Medicine Greifswald4 aut
7001 a Anttonen, Vuokkou University of Oulu,Oulu University Hospital4 aut
7001 a Laitala, Marja Liisau University of Oulu4 aut
7001 a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
7001 a Sofer, Tamaru Brigham and Women's Hospital / Harvard Medical School,Harvard University4 aut
7001 a Shaffer, John R.u University of Pittsburgh4 aut
7001 a Vieira, Alexandreu University of Pittsburgh4 aut
7001 a Marazita, Mary L.u University of Pittsburgh4 aut
7001 a Kubo, Michiakiu RIKEN Center for Integrative Medical Sciences4 aut
7001 a Furuichi, Yasushiu Hokkaido University4 aut
7001 a North, Kari E.u University of North Carolina4 aut
7001 a Offenbacher, Steveu University of North Carolina4 aut
7001 a Ingelsson, Eriku Stanford University4 aut
7001 a Franks, Paul W.u Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö SE-214 28, Sweden; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA,Avdelningen för medicin4 aut0 (Swepub:umu)pafr0003
7001 a Timpson, Nicholas J.u University of Bristol4 aut
7001 a Johansson, Ingegerdu Umeå universitet,Umeå University,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003
7102 a Umeå Universityb Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;4 org
7730 t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723
8564 u http://dx.doi.org/10.1038/s41467-019-10630-1x freey FULLTEXT
8564 u https://www.nature.com/articles/s41467-019-10630-1.pdf
8564 u https://doi.org/10.1038/s41467-019-10630-1y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1338348/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://lup.lub.lu.se/record/faec2925-abee-4bb5-bac4-9623c97f3fce
8564 8u https://doi.org/10.1038/s41467-019-10630-1
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161588
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141242177

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