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Increased overall a...
Increased overall and bacterial infections following myeloablative allogeneic HCT for patients with AML in CR1
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- Ustun, Celalettin (författare)
- Rush Univ, Div Hematol Oncol Cell Therapy, Chicago, IL 60612 USA
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- Kim, Soyoung (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA
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- Chen, Min (författare)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
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- Beitinjaneh, Amer M. (författare)
- Univ Miami, Dept Hematol, Miami, FL USA
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- Brown, Valerie, I (författare)
- Penn State Hershey Childrens Hosp & Coll Med, Div Pediat Oncol Hematol, Dept Pediat, Hershey, PA USA
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- Dahi, Parastoo B. (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA
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- Daly, Andrew (författare)
- Tom Baker Canc Clin, Calgary, AB, Canada
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- Diaz, Miguel Angel (författare)
- Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain
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- Freytes, Cesar O. (författare)
- Texas Transplant Inst, San Antonio, TX USA
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- Ganguly, Siddhartha (författare)
- Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA
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- Hashmi, Shahrukh (författare)
- Mayo Clin, Dept Internal Med, Rochester, MN USA;King Faisal Specialist Hosp & Res Ctr, Oncol Ctr, Riyadh, Saudi Arabia
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- Hildebrandt, Gerhard C. (författare)
- Univ Kentucky, Markey Canc Ctr, Lexington, KY USA
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- Lazarus, Hillard M. (författare)
- Case Western Reserve Univ, Dept Med, Stem Cell Transplant Program, Univ Hosp Cleveland,Div Hematol & Oncol, Cleveland, OH 44106 USA
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- Nishihori, Taiga (författare)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA
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- Olsson, Richard (författare)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Stockholm, Sweden
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- Page, Kristin M. (författare)
- Duke Univ, Med Ctr, Div Pediat Blood & Marrow Transplantat, Durham, NC USA
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- Papanicolaou, Genovefa (författare)
- Mem Sloan Kettering Canc Ctr, Infect Dis Serv, New York, NY 10021 USA
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- Saad, Ayman (författare)
- Ohio State Univ, Div Hematol, Columbus, OH 43210 USA
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- Seo, Sachiko (författare)
- Dokkyo Med Univ, Dept Haematol & Oncol, Mibu, Tochigi, Japan
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- William, Basem M. (författare)
- Ohio State Univ, Div Hematol, Columbus, OH 43210 USA
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- Wingard, John R. (författare)
- Univ Florida, Dept Med, Div Hematol & Oncol, Gainesville, FL USA
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- Wirk, Baldeep (författare)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA
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- Yared, Jean A. (författare)
- Univ Maryland, Blood & Marrow Transplantat Program, Div Hematol Oncol, Dept Med,Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA
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- Perales, Miguel-Angel (författare)
- Mem Sloan Kettering Canc Ctr, Dept Med, Adult Bone Marrow Transplant Serv, 1275 York Ave, New York, NY 10021 USA
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- Auletta, Jeffery J. (författare)
- Nationwide Childrens Hosp, Blood & Marrow Transplant Program, Columbus, OH USA;Nationwide Childrens Hosp, Host Def Program, Div Hematol Oncol & Blood Marrow & Transplant, Columbus, OH USA;Nationwide Childrens Hosp, Div Infect Dis, Columbus, OH USA
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- Komanduri, Krishna, V (författare)
- Univ Miami, Dept Hematol, Miami, FL USA
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- Lindemans, Caroline A. (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Pediat Blood & Marrow Transplantat Program, Utrecht, Netherlands;Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands
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- Riches, Marcie L. (författare)
- Univ North Carolina Chapel Hill, Div Hematol Oncol, Chapel Hill, NC USA
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(creator_code:org_t)
- 2019-08-30
- 2019
- Engelska.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 3:17, s. 2525-2536
- Relaterad länk:
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https://ashpublicati...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Presumably, reduced-intensity/nonmyeloablative conditioning (RIC/NMA) for allogeneic hematopoietic cell transplantation (alloHCT) results in reduced infections compared with myeloablative conditioning (MAC) regimens; however, published evidence is limited. In this Center for International Blood and Marrow Transplant Research study, 1755 patients (aged >= 40 years) with acute myeloid leukemia in first complete remission were evaluated for infections occurring within 100 days after T-cell replete alloHCT. Patients receiving RIC/NMA (n = 777) compared with those receiving MAC (n = 978) were older and underwent transplantation more recently; however, the groups were similar regarding Karnofsky performance score, HCT-comorbidity index, and cytogenetic risk. One or more infections occurred in 1045 (59.5%) patients (MAC, 595 [61%]; RIC/NMA, 450 [58%]; P = .21) by day 100. The median time to initial infection after MAC conditioning occurred earlier (MAC, 15 days [range, <1-99 days]; RIC/NMA, 21 days [range, <1-100 days]; P < .001). Patients receiving MAC were more likely to experience at least 1 bacterial infection by day 100 (MAC, 46% [95% confidence interval (CI), 43-49]; RIC/NMA, 37% [95% CI, 34-41]; P = .0004), whereas at least a single viral infection was more prevalent in the RIC/NMA cohort (MAC, 34% [95% CI, 31-37]; RIC/NMA, 39% [95% CI, 36-42]; P = .046). MAC remained a risk factor for bacterial infections in multivariable analysis (relative risk, 1.44; 95% CI, 1.23-1.67; P < .0001). Moreover, the rate of any infection per patient-days at risk in the first 100 days (infection density) after alloHCT was greater for the MAC cohort (1.21; 95% CI, 1.11-1.32; P < .0001). RIC/NMA was associated with reduced infections, especially bacterial infections, in the first 100 days after alloHCT.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Ustun, Celaletti ...
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Kim, Soyoung
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Chen, Min
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Beitinjaneh, Ame ...
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Brown, Valerie, ...
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Dahi, Parastoo B ...
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Daly, Andrew
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Diaz, Miguel Ang ...
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Freytes, Cesar O ...
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Ganguly, Siddhar ...
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Hashmi, Shahrukh
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Hildebrandt, Ger ...
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Lazarus, Hillard ...
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Nishihori, Taiga
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Olsson, Richard
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Page, Kristin M.
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Papanicolaou, Ge ...
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Saad, Ayman
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Seo, Sachiko
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William, Basem M ...
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Wingard, John R.
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Wirk, Baldeep
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Yared, Jean A.
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Perales, Miguel- ...
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Auletta, Jeffery ...
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Komanduri, Krish ...
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Lindemans, Carol ...
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Riches, Marcie L ...
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