WFRF:(Limbach Christoph)
Sökning: WFRF:(Limbach Christoph) > Molecular in situ t...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03304naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-157245 | |
| 003 | SwePub | |
| 008 | 110822s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1572452 URI |
| 024 | 7 | a https://doi.org/10.1073/pnas.11017071082 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Limbach, Christophu Uppsala universitet,Institutionen för neurovetenskap,Molecular cell biology4 aut |
| 245 | 1 0 | a Molecular in situ topology of Aczonin/Piccolo and associated proteins at the mammalian neurotransmitter release site |
| 264 | c 2011-06-28 | |
| 264 | 1 | b Proceedings of the National Academy of Sciences,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a The protein machinery of neurotransmitter exocytosis requires efficient orchestration in space and time, for speed and precision of neurotransmission and also for synaptic ontogeny and plasticity. However, its spatial organization in situ is virtually unknown. Aczonin/Piccolo is a putative organizer protein of mammalian active zones. We determined by immunogold electron microscopy (EM) (i) the spatial arrangement (i. e., topology) of 11 segments of the Aczonin polypeptide in situ, and correlated it to (ii) the positioning of Aczonin-interacting domains of Bassoon, CAST/ELKS, Munc13, and RIM and (iii) the ultrastructurally defined presynaptic macromolecular aggregates known as dense projections and synaptic ribbons. At conventional synapses, Aczonin assumes a compact molecular topology within a layer 35 to 80 nm parallel to the plasma membrane (PM), with a "trunk" sitting on the dense projection top and a C-terminal "arm" extending down toward the PM and sideward to the dense projection periphery. At ribbon synapses, Aczonin occupies the whole ribbon area. Bassoon colocalizes with Aczonin at conventional synapses but not at ribbon synapses. At both conventional and ribbon synapses, CAST, Munc13, and RIM are segregated from Aczonin, closer to the PM, and Aczonin is positioned such that it may control the access of neurotransmitter vesicles to the fusion site. | |
| 653 | a scaffolding protein | |
| 653 | a protein structure | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Laue, Michael M.4 aut |
| 700 | 1 | a Wang, Xiaolu4 aut |
| 700 | 1 | a Hu, Bin4 aut |
| 700 | 1 | a Thiede, Nadineu Uppsala universitet,Molekylär cellbiologi4 aut |
| 700 | 1 | a Hultqvist, Gretau Uppsala universitet,Institutionen för neurovetenskap,Molekylär cellbiologi4 aut0 (Swepub:uu)grhul102 |
| 700 | 1 | a Kilimann, Manfred W.u Uppsala universitet,Institutionen för neurovetenskap,Molekylär cellbiologi4 aut0 (Swepub:uu)makil021 |
| 710 | 2 | a Uppsala universitetb Institutionen för neurovetenskap4 org |
| 773 | 0 | t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciencesg 108:31, s. E392-E401q 108:31<E392-E401x 0027-8424x 1091-6490 |
| 856 | 4 | u http://21712437 |
| 856 | 4 | u https://www.pnas.org/content/pnas/108/31/E392.full.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157245 |
| 856 | 4 8 | u https://doi.org/10.1073/pnas.1101707108 |
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