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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03005naa a2200373 4500 | |
| 001 | oai:DiVA.org:umu-22455 | |
| 003 | SwePub | |
| 008 | 090511s2009 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224552 URI |
| 024 | 7 | a https://doi.org/10.1159/0002168442 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Papworth, Karin,d 1964-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)kanpah98 |
| 245 | 1 0 | a Expression of erythropoietin and its receptor in human renal cell carcinoma |
| 264 | 1 | b Springer Science and Business Media LLC,c 2009 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: To investigate the prognostic impact of erythropoietin (EPO) and EPO-receptor (EPO-R) expression in tumour as well as serum EPO in patients with renal cell carcinoma (RCC). Methods: Using immunohistochemistry, EPO and EPO-R were assessed in tissue microarrays from 195 RCCs. RCC type, TNM stage, nuclear grade, survival, EPO and haemoglobin (Hb) levels in blood were registered. Results: Strong expression of EPO and EPO-R in tumour tissue was found in 83 and 56%, respectively. EPO and EPO-R expression differed between RCC types. Serum EPO and blood Hb did not correlate to the expression of EPO or EPO-R. A positive correlation was found between the expression of EPO and EPO-R (p = 0.028). Survival was not related to tumour EPO, whereas strong EPO-R expression indicated a non-significantly worse prognosis. Serum EPO correlated positively to TNM stage and nuclear grade and negatively to survival. A multivariate analysis showed that TNM stage and nuclear grade were independent prognostic factors. Tumour EPO and EPO-R expression as well as serum EPO added no independent prognostic information. Conclusion: No correlation between EPO or EPO-R in tumour tissue and serum EPO or blood Hb was found. Neither EPO, EPO-R in tumour tissue nor serum EPO are independent prognostic factors. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a Oncology | |
| 653 | a Onkologi | |
| 653 | a Oncology | |
| 653 | a onkologi | |
| 700 | 1 | a Bergh, Andersu Umeå universitet,Patologi4 aut0 (Swepub:umu)anbe0010 |
| 700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
| 700 | 1 | a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001 |
| 700 | 1 | a Rasmuson, Torgnyu Umeå universitet,Onkologi4 aut0 (Swepub:umu)tora0001 |
| 710 | 2 | a Umeå universitetb Onkologi4 org |
| 773 | 0 | t Tumor Biologyd : Springer Science and Business Media LLCg 30:2, s. 86-92q 30:2<86-92x 1010-4283x 1423-0380 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22455 |
| 856 | 4 8 | u https://doi.org/10.1159/000216844 |
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