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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004961naa a2200769 4500
001oai:DiVA.org:umu-53502
003SwePub
008120329s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-535022 URI
0247 a https://doi.org/10.1093/carcin/bgs1332 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aleksandrova, Krasimira4 aut
2451 0a Total and high-molecular-weight adiponectin and risk of colorectal cancer :b the European prospective investigation into cancer and nutrition study
264 c 2012-03-19
264 1b Oxford University Press (OUP),c 2012
338 a print2 rdacarrier
520 a Adiponectin - an adipose-tissue-derived protein may provide a molecular link between obesity and colorectal cancer (CRC), but evidence from large prospective studies is limited. In particular, no epidemiological study explored high-molecular-weight (HMW) and non-HMW adiponectin fractions in relation to CRC risk, despite they were hypothesised to have differential biological activities, i.e. regulating insulin sensitivity (HMW-adiponectin) versus inflammatory response (non-HMW-adiponectin). In a prospective nested case-control study we investigated whether pre-diagnostic serum concentrations of total, HMW and non-HMW-adiponectin are associated with risk of CRC, independent of obesity and other known CRC risk factors. A total of 1206 incident cases (755 colon, 451 rectal) were matched to 1206 controls using incidence density sampling. In conditional logistic regression, adjusted for dietary and lifestyle factors, total adiponectin and non-HMW-adiponectin concentrations were inversely associated with risk of CRC [relative risk (RR) comparing highest versus lowest quintile = 0.71, 95% confidence interval (CI) = 0.53-0.95, P (trend)=0.03 for total adiponectin and 0.45, 95%CI=0.34-0.61, P (trend)<0.0001 for non-HMW-adiponectin]. HMW-adiponectin concentrations were not associated with CRC risk (RR=0.91, 95%CI=0.68-1.22, P (trend)=0.55). Non-HMW-adiponectin was associated with CRC risk even after adjustment for body mass index and waist circumference (RR=0.39, 95%CI=0.26-0.60, P (trend)<0.0001); whereas the association with total adiponectin was no longer significant (RR=0.81, 95%CI=0.60-1.09, P (trend)=0.23). When stratified by cancer site, non-HMW-adiponectin was inversely associated with both colon and rectal cancer. These findings suggest an important role of the relative proportion of non-HMW-adiponectin in CRC pathogenesis. Future studies are warranted to confirm these results and to elucidate the underlying mechanisms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Boeing, Heiner4 aut
7001 a Jenab, Mazda4 aut
7001 a Bueno-de-Mesquita, H Bas4 aut
7001 a Jansen, Eugene4 aut
7001 a van Duijnhoven, Fränzel JB4 aut
7001 a Fedirko, Veronika4 aut
7001 a Rinaldi, Sabina4 aut
7001 a Romieu, Isabelle4 aut
7001 a Riboli, Elio4 aut
7001 a Romaguera, Dora4 aut
7001 a Westphal, Sabine4 aut
7001 a Overvad, Kim4 aut
7001 a Tjønneland, Anne4 aut
7001 a Boutron-Ruault, Marie Christine4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Lukanova, Annekatrin4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Lagiou, Pagona4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Agnoli, Claudia4 aut
7001 a Mattiello, Amalia4 aut
7001 a Saieva, Calogero4 aut
7001 a Vineis, Paolo4 aut
7001 a Tumino, Rosario4 aut
7001 a Peeters, Petra H4 aut
7001 a Argüelles, Marcial4 aut
7001 a Bonet, Catalina4 aut
7001 a Sánchez, María-José4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Huerta, Jose-María4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
7001 a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Allen, Naomi E4 aut
7001 a Crowe, Francesca L4 aut
7001 a Pischon, Tobias4 aut
7102 a Umeå universitetb Patologi4 org
7730 t Carcinogenesisd : Oxford University Press (OUP)g 33:6, s. 1211-1218q 33:6<1211-1218x 0143-3334x 1460-2180
8564 u https://academic.oup.com/carcin/article-pdf/33/6/1211/17290932/bgs133.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53502
8564 8u https://doi.org/10.1093/carcin/bgs133

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