Sökning: WFRF:(Lund Johan) > (2015-2019) > Association of Card...
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000 | 07763naa a2201333 4500 | |
001 | oai:DiVA.org:uu-259089 | |
003 | SwePub | |
008 | 150727s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2590892 URI |
024 | 7 | a https://doi.org/10.1001/jama.2015.70082 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Di Angelantonio, Emanuele4 aut |
245 | 1 0 | a Association of Cardiometabolic Multimorbidity With Mortality :b The Emerging Risk Factors Collaboration |
264 | 1 | b American Medical Association (AMA),c 2015 |
338 | a print2 rdacarrier | |
520 | a IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing.OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity.DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128 843 deaths). The HRs from the Emerging Risk Factors Collaboration were compared with those from the UK Biobank (499 808 participants; years of baseline surveys: 2006-2010; latest mortality follow-up: November 2013; 7995 deaths). Cumulative survival was estimated by applying calculated age-specific HRs for mortality to contemporary US age-specific death rates. EXPOSURES A history of 2 or more of the following: diabetes mellitus, stroke, myocardial infarction (MI).MAIN OUTCOMES AND MEASURES All-cause mortality and estimated reductions in life expectancy.RESULTS In participants in the Emerging Risk Factors Collaboration without a history of diabetes, stroke, or MI at baseline (reference group), the all-cause mortality rate adjusted to the age of 60 years was 6.8 per 1000 person-years. Mortality rates per 1000 person-years were 15.6 in participants with a history of diabetes, 16.1 in those with stroke, 16.8 in those with MI, 32.0 in those with both diabetes and MI, 32.5 in those with both diabetes and stroke, 32.8 in those with both stroke and MI, and 59.5 in those with diabetes, stroke, and MI. Compared with the reference group, the HRs for all-cause mortality were 1.9 (95% CI, 1.8-2.0) in participants with a history of diabetes, 2.1 (95% CI, 2.0-2.2) in those with stroke, 2.0 (95% CI, 1.9-2.2) in those with MI, 3.7 (95% CI, 3.3-4.1) in those with both diabetes and MI, 3.8 (95% CI, 3.5-4.2) in those with both diabetes and stroke, 3.5 (95% CI, 3.1-4.0) in those with both stroke and MI, and 6.9 (95% CI, 5.7-8.3) in those with diabetes, stroke, and MI. The HRs from the Emerging Risk Factors Collaboration were similar to those from the more recently recruited UK Biobank. The HRs were little changed after further adjustment for markers of established intermediate pathways (eg, levels of lipids and blood pressure) and lifestyle factors (eg, smoking, diet). At the age of 60 years, a history of any 2 of these conditions was associated with 12 years of reduced life expectancy and a history of all 3 of these conditions was associated with 15 years of reduced life expectancy.CONCLUSIONS AND RELEVANCE Mortality associated with a history of diabetes, stroke, or MI was similar for each condition. Because any combination of these conditions was associated with multiplicative mortality risk, life expectancy was substantially lower in people with multimorbidity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Kaptoge, Stephen4 aut |
700 | 1 | a Wormser, David4 aut |
700 | 1 | a Willeit, Peter4 aut |
700 | 1 | a Butterworth, Adam S.4 aut |
700 | 1 | a Bansal, Narinder4 aut |
700 | 1 | a O'Keeffe, Linda M.4 aut |
700 | 1 | a Gao, Pei4 aut |
700 | 1 | a Wood, Angela M.4 aut |
700 | 1 | a Burgess, Stephen4 aut |
700 | 1 | a Freitag, Daniel F.4 aut |
700 | 1 | a Pennells, Lisa4 aut |
700 | 1 | a Peters, Sanne A.4 aut |
700 | 1 | a Hart, Carole L.4 aut |
700 | 1 | a Haheim, Lise Lund4 aut |
700 | 1 | a Gillum, Richard F.4 aut |
700 | 1 | a Nordestgaard, Borge G.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Yeap, Bu B.4 aut |
700 | 1 | a Knuiman, Matthew W.4 aut |
700 | 1 | a Nietert, Paul J.4 aut |
700 | 1 | a Kauhanen, Jussi4 aut |
700 | 1 | a Salonen, Jukka T.4 aut |
700 | 1 | a Kuller, Lewis H.4 aut |
700 | 1 | a Simons, Leon A.4 aut |
700 | 1 | a van der Schouw, Yvonne T.4 aut |
700 | 1 | a Barrett-Connor, Elizabeth4 aut |
700 | 1 | a Selmer, Randi4 aut |
700 | 1 | a Crespo, Carlos J.4 aut |
700 | 1 | a Rodriguez, Beatriz4 aut |
700 | 1 | a Verschuren, W. M. Monique4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Svärdsudd, Kurt,d 1942-u Uppsala universitet,Allmänmedicin och preventivmedicin4 aut0 (Swepub:uu)kurtsvar |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Bjorkelund, Cecilia4 aut |
700 | 1 | a Wilhelmsen, Lars4 aut |
700 | 1 | a Wallace, Robert B.4 aut |
700 | 1 | a Brenner, Hermann4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Barr, Elizabeth L. M.4 aut |
700 | 1 | a Iso, Hiroyasu4 aut |
700 | 1 | a Onat, Altan4 aut |
700 | 1 | a Trevisan, Maurizio4 aut |
700 | 1 | a D'Agostino, Ralph B., Sr.4 aut |
700 | 1 | a Cooper, Cyrus4 aut |
700 | 1 | a Kavousi, Maryam4 aut |
700 | 1 | a Welin, Lennart4 aut |
700 | 1 | a Roussel, Ronan4 aut |
700 | 1 | a Hu, Frank B.4 aut |
700 | 1 | a Sato, Shinichi4 aut |
700 | 1 | a Davidson, Karina W.4 aut |
700 | 1 | a Howard, Barbara V.4 aut |
700 | 1 | a Leening, Maarten4 aut |
700 | 1 | a Rosengren, Annika4 aut |
700 | 1 | a Dorr, Marcus4 aut |
700 | 1 | a Deeg, Dorly J. H.4 aut |
700 | 1 | a Kiechl, Stefan4 aut |
700 | 1 | a Stehouwer, Coen D. A.4 aut |
700 | 1 | a Nissinen, Aulikki4 aut |
700 | 1 | a Giampaoli, Simona4 aut |
700 | 1 | a Donfrancesco, Chiara4 aut |
700 | 1 | a Kromhout, Daan4 aut |
700 | 1 | a Price, Jackie F.4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Meade, Tom W.4 aut |
700 | 1 | a Casiglia, Edoardo4 aut |
700 | 1 | a Lawlor, Debbie A.4 aut |
700 | 1 | a Gallacher, John4 aut |
700 | 1 | a Nagel, Dorothea4 aut |
700 | 1 | a Franco, Oscar H.4 aut |
700 | 1 | a Assmann, Gerd4 aut |
700 | 1 | a Dagenais, Gilles R.4 aut |
700 | 1 | a Jukema, J. Wouter4 aut |
700 | 1 | a Sundström, Johanu Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)johasund |
700 | 1 | a Woodward, Mark4 aut |
700 | 1 | a Brunner, Eric J.4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Whitsel, Eric A.4 aut |
700 | 1 | a Njolstad, Inger4 aut |
700 | 1 | a Hedblad, Bo4 aut |
700 | 1 | a Wassertheil-Smoller, Sylvia4 aut |
700 | 1 | a Engstrom, Gunnar4 aut |
700 | 1 | a Rosamond, Wayne D.4 aut |
700 | 1 | a Selvin, Elizabeth4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Thompson, Simon G.4 aut |
700 | 1 | a Danesh, John4 aut |
710 | 2 | a Uppsala universitetb Allmänmedicin och preventivmedicin4 org |
773 | 0 | t Journal of the American Medical Association (JAMA)d : American Medical Association (AMA)g 314:1, s. 52-60q 314:1<52-60x 0098-7484x 1538-3598 |
856 | 4 | u https://jamanetwork.com/journals/jama/articlepdf/2382980/joi150068.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259089 |
856 | 4 8 | u https://doi.org/10.1001/jama.2015.7008 |
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