WFRF:(Mallone R)
Sökning: WFRF:(Mallone R) > Regulatory T cell p...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04361naa a2200529 4500 | |
| 001 | oai:DiVA.org:liu-93379 | |
| 003 | SwePub | |
| 008 | 130531s2013 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-933792 URI |
| 024 | 7 | a https://doi.org/10.1111/cei.120782 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Pihl, Mikaelu Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)mikpi27 |
| 245 | 1 0 | a Regulatory T cell phenotype and function 4 years after GAD–alum treatment in children with type 1 diabetes |
| 264 | c 2013-04-18 | |
| 264 | 1 | b Wiley-Blackwell,c 2013 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding Agencies|Swedish Research Council|K2008-55x-20652-01-3|Swedish Child Diabetes Foundation (Barndiabetesfonden)||Medical Research Council of Southeast Sweden||JDRF|1-2008-106|Ile-de-France CODDIM||Inserm Avenir Program|| | |
| 520 | a Glutamic acid decarboxylase (GAD)65 formulated with aluminium hydroxide (GAD-alum) was effective in preserving insulin secretion in a Phase II clinical trial in children and adolescents with recent-onset type 1 diabetes. In addition, GAD-alum treated patients increased CD4+CD25hi forkhead box protein 3+ (FoxP3+) cell numbers in response to in-vitro GAD65 stimulation. We have carried out a 4-year follow-up study of 59 of the original 70 patients to investigate long-term effects on the frequency and function of regulatory T cells after GAD-alum treatment. Peripheral blood mononuclear cells were stimulated in vitro with GAD65 for 7 days and expression of regulatory T cell markers was measured by flow cytometry. Regulatory T cells (CD4+CD25hiCD127lo) and effector T cells (CD4+CD25–CD127+) were further sorted, expanded and used in suppression assays to assess regulatory T cell function after GAD-alum treatment. GAD-alum-treated patients displayed higher frequencies of in-vitro GAD65-induced CD4+CD25+CD127+ as well as CD4+CD25hiCD127lo and CD4+FoxP3+ cells compared to placebo. Moreover, GAD65 stimulation induced a population of CD4hi cells consisting mainly of CD25+CD127+, which was specific of GAD-alum-treated patients (16 of 25 versus one of 25 in placebo). Assessment of suppressive function in expanded regulatory T cells revealed no difference between GAD-alum- and placebo-treated individuals. Regulatory T cell frequency did not correlate with C-peptide secretion throughout the study. In conclusion, GAD-alum treatment induced both GAD65-reactive CD25+CD127+ and CD25hiCD127lo cells, but no difference in regulatory T cell function 4 years after GAD-alum treatment. | |
| 653 | a CD4 T cells (T helper | |
| 653 | a Th0 | |
| 653 | a Th1 | |
| 653 | a Th2 | |
| 653 | a Th3 | |
| 653 | a Th17) | |
| 653 | a diabetes | |
| 653 | a immune regulation | |
| 653 | a regulatory T cells (Treg) | |
| 653 | a therapy/immunotherapy | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Åkerman, Lindau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)linak20 |
| 700 | 1 | a Axelsson, Stinau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)stiax77 |
| 700 | 1 | a Chéramy, Mikaelu Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)mikch88 |
| 700 | 1 | a Hjorth, Mariau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)marhe44 |
| 700 | 1 | a Mallone, R.u St Vincent Paul Hospital, France4 aut |
| 700 | 1 | a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29 |
| 700 | 1 | a Casas, Rosaurau Linköpings universitet,Pediatrik,Hälsouniversitetet4 aut0 (Swepub:liu)rosca56 |
| 710 | 2 | a Linköpings universitetb Pediatrik4 org |
| 773 | 0 | t Clinical and Experimental Immunologyd : Wiley-Blackwellg 172:3, s. 394-402q 172:3<394-402x 0009-9104x 1365-2249 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:624505/FULLTEXT01.pdfx primaryx Raw objecty fulltext:preprint |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646438 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-93379 |
| 856 | 4 8 | u https://doi.org/10.1111/cei.12078 |
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