SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Moss Sue M.)
 

Search: WFRF:(Moss Sue M.) > Prostate Cancer Mor...

Prostate Cancer Mortality Reduction by Prostate-Specific Antigen-Based Screening Adjusted for Nonattendance and Contamination in the European Randomised Study of Screening for Prostate Cancer (ERSPC)

Roobol, Monique J. (author)
Kerkhof, Melissa (author)
Schroeder, Fritz H. (author)
show more...
Cuzick, Jack (author)
Sasieni, Peter (author)
Hakama, Matti (author)
Stenman, Ulf Hakan (author)
Ciatto, Stefano (author)
Nelen, Vera (author)
Kwiatkowski, Maciej (author)
Lujan, Marcos (author)
Lilja, Hans (author)
Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
Zappa, Marco (author)
Denis, Louis (author)
Recker, Franz (author)
Berenguer, Antonio (author)
Ruutu, Mirja (author)
Kujala, Paula (author)
Bangma, Chris H. (author)
Aus, Gunnar (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
Tammela, Teuvo L. J. (author)
Villers, Arnauld (author)
Rebillard, Xavier (author)
Moss, Sue M. (author)
de Koning, Harry J. (author)
Hugosson, Jonas, 1955 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
Auvinen, Anssi (author)
show less...
 (creator_code:org_t)
Elsevier BV, 2009
2009
English.
In: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 56:4, s. 584-591
Related links:
http://dx.doi.org/10...
show more...
https://lup.lub.lu.s...
https://doi.org/10.1...
https://gup.ub.gu.se...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Background: Prostate-specific antigen (PSA) based screening for prostate cancer (PCa) has been shown to reduce prostate specific mortality by 20% in an intention to screen (ITS) analysis in a randomised trial (European Randomised Study of Screening for Prostate Cancer [ERSPC]). This effect may be diluted by nonattendance in men randomised to the screening arm and contamination in men randomised to the control arm. Objective: To assess the magnitude of the PCa-specific mortality reduction after adjustment for nonattendance and contamination. Design, setting, and participants: We analysed the occurrence of PCa deaths during an average follow-up of 9 yr in 162 243 men 55-69 yr of age randomised in seven participating centres of the ERSPC. Centres were also grouped according to the type of randomisation (ie, before or after informed written consent). Intervention: Nonattendance was defined as nonattending the initial screening round in ERSPC. The estimate of contamination was based on PSA use in controls in ERSPC Rotterdam. Measurements: Relative risks (RRs) with 95% confidence intervals (Cis) were compared between an ITS analysis and analyses adjusting for nonattendance and contamination using a statistical method developed for this purpose. Results and limitations: In the ITS analysis, the RR of PCa death in men allocated to the intervention arm relative to the control arm was 0.80 (95% CI, 0.68-0.96). Adjustment for nonattendance resulted in a RR of 0.73 (95% CI, 0.58-0.93), and additional adjustment for contamination using two different estimates led to estimated reductions of 0.69 (95% CI, 0.51-0.92) to 0.71 (95% CI, 0.55-0.93), respectively. Contamination data were obtained through extrapolation of single-centre data. No heterogeneity was found between the groups of centres. Conclusions: PSA screening reduces the risk of dying of PCa by up to 31% in men actually screened. This benefit should be weighed against a degree of over diagnosis and overtreatment inherent in PCa screening. (C) 2009 European Association of Urology. Published by Elsevier B.V. All rights reserved.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Urology and Nephrology (hsv//eng)

Keyword

Non compliance
Mortality reduction
Prostate cancer
Screening
Contamination
Adjusted analysis

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view