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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02189naa a2200301 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:134526712 | |
| 003 | SwePub | |
| 008 | 240913s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1345267122 URI |
| 024 | 7 | a https://doi.org/10.1177/15333175166547572 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Boccia, M4 aut |
| 245 | 1 0 | a Neural Underpinnings of the Decline of Topographical Memory in Mild Cognitive Impairment |
| 264 | c 2016-07-09 | |
| 264 | 1 | b SAGE Publications,c 2016 |
| 520 | a Spatial navigation is one of the cognitive functions known to decline in both normal and pathological aging. In the present study, we aimed to assess the neural correlates of the decline of topographical memory in patients with amnestic mild cognitive impairment (aMCI). Patients with aMCI and age-matched controls were engaged in an intensive learning paradigm, lasting for 5 days, during which they had to encode 1 path from an egocentric perspective and 1 path from an allocentric perspective. After the learning period, they were asked to retrieve each of these paths using an allocentric or egocentric frame of reference while undergoing a functional magnetic resonance imaging scan. We found that patients with aMCI showed a specific deficit in storing new topographical memories from an allocentric perspective and retrieving stored information to perform the egocentric task. Imaging data suggest that this general decline is correlated with hypoactivation of the brain areas generally involved in spatial navigation. | |
| 700 | 1 | a Silveri, MC4 aut |
| 700 | 1 | a Sabatini, U4 aut |
| 700 | 1 | a Guariglia, C4 aut |
| 700 | 1 | a Nemmi, Fu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t American journal of Alzheimer's disease and other dementiasd : SAGE Publicationsg 31:8, s. 618-630q 31:8<618-630x 1938-2731x 1533-3175 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:134526712 |
| 856 | 4 8 | u https://doi.org/10.1177/1533317516654757 |
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- Boccia, M
- Silveri, MC
- Sabatini, U
- Guariglia, C
- Nemmi, F
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