Crystal structure of human glyoxalase II and its complex with a glutathione thiolester substrate analogue

• Background: Glyoxalase II, the second of two enzymes in the glyoxalase system, is a thiolesterase that catalyses the hydrolysis of S-D-lactoylgtutathione to form glutathione and D-lactic acid. Results: The structure of human glyoxalase II was solved initi

Nyckelord

binuclear zinc site; crystal structure; glyoxalase II; glutathione; thiolesterase; METALLO-BETA-LACTAMASE; ANGSTROM RESOLUTION; BACILLUS-CEREUS; BACTEROIDES-FRAGILIS; ARABIDOPSIS-THALIANA; ACTIVE-SITE; ZINC; REFINEMENT; INHIBITION; ALIGNMENT

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