Occupational exposures and Mycosis Fungoides. A European multicentre case-control study (Europe)

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Occupational exposures and Mycosis Fungoides. A European multicentre case-control study (Europe)

Morales-Suarez-Varela, M.M. (författare): Morales-Suárez-Varela, M.M., Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Spain, Unit of Clinical Epidemiology, Dr. Peset University Hospital, Valencia, Spain, Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Avda, Vicente Andres Estelles s/n, 46100 Burjasot, Valencia, Spain

Olsen, J. (författare): Danish Epidemiology Science Centre, University of Aarhus, Denmark

Johansen, P. (författare): Institute of Pathology, Aalborg Hospital, Aalborg, Denmark

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Kaerlev, L. (författare): Danish Epidemiology Science Centre, University of Aarhus, Denmark

Guenel, P. (författare): Guénel, P., INSERM Unité, 170, Villejuif, France

Arveux, P. (författare): Registre des Cancers du Doubs, France

Wingren, Gun (författare): Linköpings universitet,Hälsouniversitetet,Yrkes- och miljömedicin

Hardell, L. (författare): Department of Oncology, Orebro Medical Centre, Sweden

Ahrens, W. (författare): Division of Biometry and Data Processing, Bremen Institute for Prevention Research and Social Medicine, Bremen, Germany, Institute for Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Germany

Stang, A. (författare): Institute for Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Germany

Llopis, A. (författare): Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Spain

Merletti, F. (författare): Unit of Cancer Epidemiology, CERMS and Centre for Oncologic Prevention, University of Turin, Italy

Aurrekoetxea, J.J. (författare): Department of Preventive Medicine and Public Health, University of the Basque Country, Spain

Masala, G. (författare): Molecular and Nutritional Epidemiology Unit, CSPO, Scientific Institute of Tuscany, Florence, Italy

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Morales-Suárez-Varela, MM., Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Spain, Unit of Clinical Epidemiology, Dr. Peset University Hospital, Valencia, Spain, Department of Preventive Medicine, Unit of Public Health and Environmental Care, University of Valencia, Avda, Vicente Andres Estelles s/n, 46100 Burjasot, Valencia, Spain Danish Epidemiology Science Centre, University of Aarhus, Denmark (creator_code:org_t)

Springer Science and Business Media LLC, 2005
2005
Engelska.
Ingår i: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 16:10, s. 1253-1259

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Objectives: Mycosis Fungoides (MF) is a rare disease with an occurrence indicating that occupational exposures may play a role. To estimate the association between MF and occupational exposures as measured by means of an job-exposure matrix (JEM). Methods: A European multicenter case-control study was conducted from 1995 to 1997 and included seven rare cancers, one of which was MF. Patients between 35 and 69 years of age, diagnosed with MF (n = 140), were recruited and the diagnoses were checked by a reference pathologist who classified 83 cases as definite, 35 cases as possible and 22 cases as not accepted. Among the 118 accepted cases, 104 cases were interviewed, of which 76 were definite cases. We selected population controls and colon cancer controls to serve all seven case groups. Altogether 833 colon cancer controls and 2071 population controls were interviewed. Based on the reported occupational experiences, a team of industrial hygiene specialists identified five potential exposures and developed an JEM. This JEM was used to estimate the odds ratios (OR) for MF as a function of these exposures. The JEM included aromatic and/or halogenated hydrocarbons (AAHs), chrome (VI) and its salts, electromagnetic radiations, silica and pesticides. Results: Exposures to AHHs (OR 6.3, C.I 2.4-16.7 for male) were associated with a high MF risk. Conclusions: The study supports the hypothesis that some MFs have an occupational etiology but only a small fraction of exposed workers are apparently susceptible since the disease is so rare. © Springer 2005.

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Av författaren/redakt...: Morales-Suarez-V ...; Olsen, J.; Johansen, P.; Kaerlev, L.; Guenel, P.; Arveux, P.; visa fler...; Wingren, Gun; Hardell, L.; Ahrens, W.; Stang, A.; Llopis, A.; Merletti, F.; Aurrekoetxea, J. ...; Masala, G.; visa färre...

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Occupational exposures and Mycosis Fungoides. A European multicentre case-control study (Europe)

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