WFRF:(Petranovic Nielsen Dina 1975)
Search: WFRF:(Petranovic Nielsen Dina 1975) > Genome-Scale Modeli...
- 9 of 63
- Previous record
- Next record
- To hitlist
Genome-Scale Modeling of the Protein Secretory Machinery in Yeast
-
- Feizi, Amir, 1980 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Österlund, Tobias, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Petranovic Nielsen, Dina, 1975 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
- show more...
- show less...
- (creator_code:org_t)
- 2013-05-07
- 2013
- English.
- In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203 .- 1932-6203. ; 8:5
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The protein secretory machinery in Eukarya is involved in post-translational modification (PTMs) and sorting of the secretory and many transmembrane proteins. While the secretory machinery has been well-studied using classic reductionist approaches, a holistic view of its complex nature is lacking. Here, we present the first genome-scale model for the yeast secretory machinery which captures the knowledge generated through more than 50 years of research. The model is based on the concept of a Protein Specific Information Matrix (PSIM: characterized by seven PTMs features). An algorithm was developed which mimics secretory machinery and assigns each secretory protein to a particular secretory class that determines the set of PTMs and transport steps specific to each protein. Protein abundances were integrated with the model in order to gain system level estimation of the metabolic demands associated with the processing of each specific protein as well as a quantitative estimation of the activity of each component of the secretory machinery.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
- 9 of 63
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Feizi, Amir, 198 ...
- Österlund, Tobia ...
- Petranovic Niels ...
- Velasco, Sergio, ...
- Nielsen, Jens B, ...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- and Microbiology
- Articles in the publication
- PLoS ONE
- By the university
- Chalmers University of Technology
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
