MicroRNA let-7 Modulates the Immune Response to Mycobacterium tuberculosis Infection via Control of A20, an Inhibitor of the NF-κB Pathway.

Kumar, Manish (author): Department of Chemistry, Bose Institute, Kolkata 700009, India

Sahu, Sanjaya Kumar (author): Department of Chemistry, Bose Institute, Kolkata 700009, India

Kumar, Ranjeet (author): Department of Chemistry, Bose Institute, Kolkata 700009, India

Subuddhi, Arijita (author): Department of Chemistry, Bose Institute, Kolkata 700009, India

Maji, Ranjan Kumar (author): Bioinformatics Centre, Bose Institute, Kolkata 700054, India

Jana, Kuladip (author): Division of Molecular Medicine, Bose Institute, Kolkata 700054, India

Gupta, Pushpa (author): National Jalma Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282006, India

Raffetseder, Johanna (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

Lerm, Maria (author): Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet

Ghosh, Zhumur (author): Bioinformatics Centre, Bose Institute, Kolkata 700054, India

van Loo, Geert (author): VIB Inflammation Research Center, Ghent University, 9052 Ghent / Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium

Beyaert, Rudi (author): VIB Inflammation Research Center, Ghent University, 9052 Ghent / Department of Biomedical Molecular Biology, Ghent University, 9052 Ghent, Belgium

Gupta, Umesh D (author): National Jalma Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra 282006, India

Kundu, Manikuntala (author): Bioinformatics Centre, Bose Institute, Kolkata 700054, India

Basu, Joyoti (author): Bioinformatics Centre, Bose Institute, Kolkata 700054, India

(creator_code:org_t)

elsevier, 2015
2015
English.
In: Cell host & microbe. - : elsevier. - 1934-6069 .- 1931-3128. ; 17:3, s. 345-56

Related links:: http://www.cell.com/...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

The outcome of the interaction between Mycobacterium tuberculosis (Mtb) and a macrophage depends on the interplay between host defense and bacterial immune subversion mechanisms. MicroRNAs critically regulate several host defense mechanisms, but their role in the Mtb-macrophage interplay remains unclear. MicroRNA profiling of Mtb-infected macrophages revealed the downregulation of miR-let-7f in a manner dependent on the Mtb secreted effector ESAT-6. We establish that let-7f targets A20, a feedback inhibitor of the NF-κB pathway. Expression of let-7f decreases and A20 increases with progression of Mtb infection in mice. Mtb survival is attenuated in A20-deficient macrophages, and the production of TNF, IL-1β, and nitrite, which are mediators of immunity to Mtb, is correspondingly increased. Further, let-7f overexpression diminishes Mtb survival and augments the production of cytokines including TNF and IL-1β. These results uncover a role for let-7f and its target A20 in regulating immune responses to Mtb and controlling bacterial burden.

By the author/editor: Kumar, Manish; Sahu, Sanjaya Ku ...; Kumar, Ranjeet; Subuddhi, Arijit ...; Maji, Ranjan Kum ...; Jana, Kuladip; show more...; Gupta, Pushpa; Raffetseder, Joh ...; Lerm, Maria; Ghosh, Zhumur; van Loo, Geert; Beyaert, Rudi; Gupta, Umesh D; Kundu, Manikunta ...; Basu, Joyoti; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Microbiology in ...

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