Cox‐2 Regulation Differs Between Sexes in the Secondary Inflammatory Response Following Experimental Penetrating Focal Brain Injury in Rats

Günther, Mattias (author)

Plantman, Stefan (author)

Davidsson, Johan, 1967 (author): Chalmers tekniska högskola,Chalmers University of Technology

Angéria, Maria (author)

Mathiesen, Tiit (author)

Risling, Mårten (author)

(creator_code:org_t)

Abstract Subject headings

Traumatic brain injury (TBI) is followed by secondary neuronal degeneration, largely dependent on an inflammatory response. This response is probably gender specific, since females are generally better protected than males in animal models and human epidemiological studies of TBI. The reasons are not fully known. We examined aspects of the inflammatory response following experimental TBI in male and female rats to explore possible gender differences. A penetrating brain injury model was used to produce focal TBI in male (n=10) and female (n=10) rats. After 24 h and 72 h the brains were removed and subjected to immunohistochemical analyses and in situ hybridization. Cox‐2 mRNA was elevated in the perilesional area compared to the un‐injured contralateral side, and significantly higher in males compared to females at 24 h and 72 h (p

By the author/editor: Günther, Mattias; Plantman, Stefan; Davidsson, Johan ...; Angéria, Maria; Mathiesen, Tiit; Risling, Mårten

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.